Good Cosmetic Ingredient

Tyrosyl Histidine HCl

INCI: TYROSYL HISTIDINE HCL

CAS Number
94111-42-9
Function
Antioxidant
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Not specifically listed; permissible under general cosmetic ingredient provisions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Critical note: Entries \#5 and \#6 share CAS 94111-42-9 and are chemically identical. The "HCI" vs "HCl" distinction is a typographical issue (uppercase I vs lowercase L). CosIng may list both variants — always use the exact INCI spelling from the official CosIng record for labeling compliance

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Concern Level: Low

Frequently Asked Questions

Is Tyrosyl Histidine HCl safe in cosmetics?

Critical note: Entries \#5 and \#6 share CAS 94111-42-9 and are chemically identical. The "HCI" vs "HCl" distinction is a typographical issue (uppercase I vs lowercase L). CosIng may list both variants — always use the exact INCI spelling from the official CosIng record for labeling compliance The EU classifies Tyrosyl Histidine HCl as "permitted". Safety rating: GOOD.

Is Tyrosyl Histidine HCl allowed in the EU?

Tyrosyl Histidine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tyrosyl Histidine HCl do in cosmetics?

Tyrosyl Histidine HCl functions as: Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 94111-42-9.

What is the Margin of Safety for Tyrosyl Histidine HCl?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Tyrosyl Histidine HCl compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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