Good Cosmetic Ingredient

Urea-D-Glucuronic Acid

INCI: UREA-D-GLUCURONIC ACID

CAS Number
Not assigned in standard databases (complex/adduct of urea CAS 57-13-6 + D-glucuronic acid CAS 6556-12-3)
Function
Humectant, skin conditioning agent (combining urea's keratolytic/moisturizing properties with glucuronic acid's hydrating function)
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status restricted
US Notes Not specifically restricted; both parent compounds are well-established cosmetic ingredients

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

If urea content >10%, some jurisdictions may classify the product as a medical device or OTC drug. Verify that the complex dissociates predictably — confirm pH stability in formulation. Very limited standalone safety data for the conjugated form

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Concern Level: Low

Frequently Asked Questions

Is Urea-D-Glucuronic Acid safe in cosmetics?

If urea content >10%, some jurisdictions may classify the product as a medical device or OTC drug. Verify that the complex dissociates predictably — confirm pH stability in formulation. Very limited standalone safety data for the conjugated form The EU classifies Urea-D-Glucuronic Acid as "permitted". Safety rating: GOOD.

Is Urea-D-Glucuronic Acid allowed in the EU?

Urea-D-Glucuronic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Urea-D-Glucuronic Acid do in cosmetics?

Urea-D-Glucuronic Acid functions as: Humectant, skin conditioning agent (combining urea's keratolytic/moisturizing properties with glucuronic acid's hydrating function). It is classified as a cosmetic ingredient in our database. CAS number: Not assigned in standard databases (complex/adduct of urea CAS 57-13-6 + D-glucuronic acid CAS 6556-12-3).

What is the Margin of Safety for Urea-D-Glucuronic Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Urea-D-Glucuronic Acid compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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