Valine
INCI: VALINE (L-VALINE; 2-AMINO-3-METHYLBUTANOIC ACID)
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Valine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3721 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 628 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 3225 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
None; endogenous to human skin and body; no known safety concerns at any cosmetic concentration
Regulatory Flags
Frequently Asked Questions
Is Valine safe in cosmetics?
None; endogenous to human skin and body; no known safety concerns at any cosmetic concentration The EU classifies Valine as "permitted". Safety rating: EXCELLENT. 3 toxicological study endpoint(s) are available in our database.
Is Valine allowed in the EU?
Valine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Valine do in cosmetics?
Valine functions as: Antistatic, Hair Conditioning, Skin Conditioning, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 72-18-4.
What is the Margin of Safety for Valine?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Valine?
The NOAEL (No Observed Adverse Effect Level) for Valine is 3721 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
Check Valine compliance across multiple jurisdictions:
Related Ingredients
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