NOAEL Studies Humectant

Xylitol NOAEL Studies

INCI: XYLITOL

CAS: 87-99-0

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 19 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 680 mg/kg bw/day rat oral 686 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1000 mg/kg bw/day monkey oral 94 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 1250 mg/kg bw/day dog oral 728 day Chronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2200 mg/kg bw/day mouse oral 105 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 2500 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 5000 mg/kg bw/day rat oral 56 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 6770 mg/kg bw/day rabbit oral 13 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 7500 mg/kg bw/day mouse oral 23 day Special Toxicology Study US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 8500 mg/kg bw/day mouse oral 714 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 9167 mg/kg bw/day rat oral 126 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 9847 mg/kg bw/day rat oral 686 day Carcinogenicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 10000 mg/kg bw/day rat oral 14 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 12100 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 15000 mg/kg bw/day mouse oral 168 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 20100 mg/kg bw/day mouse oral 112 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 25200 mg/kg bw/day mouse oral 112 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 26667 mg/kg bw/day mouse oral 126 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 27188 mg/kg bw/day mouse oral 112 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 50000 mg/kg bw/day mouse oral 147 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA LOAEL 6770 mg/kg bw/day rabbit oral: feed - developmental toxicity dossier=f192f352-2a99-4d22-a4f4-5eedeba51287.i6z; document=f0b5c810-e942-4165-8bbe-eefbd23d7ccd_f192f352-2a99-4d22-a4f4-5eedeba51287.i6d; document_key=f0b5c810-e942-4165-8bbe-eefbd23d7ccd/f192f352-2a99-4d22-a4f4-5eedeba51287; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-01-09; basis=body weight and weight gain; key_result=false; entry_uuid=d526d5ff-3d52-46a3-8696-e5c49b423164
ECHA NOAEL 4170 mg/kg bw/day rabbit oral: feed - developmental toxicity dossier=f192f352-2a99-4d22-a4f4-5eedeba51287.i6z; document=f0b5c810-e942-4165-8bbe-eefbd23d7ccd_f192f352-2a99-4d22-a4f4-5eedeba51287.i6d; document_key=f0b5c810-e942-4165-8bbe-eefbd23d7ccd/f192f352-2a99-4d22-a4f4-5eedeba51287; document_subtype=DevelopmentalToxicityTeratogenicity; literature=Name=Unnamed; ReferenceYear=1978; ReportDate=1978-01-09; basis=body weight and weight gain; key_result=false; entry_uuid=33efec15-378f-44b6-ace9-d631a140d6f8
ECHA NOAEL =6770 mg/kg bw/day Rabbit oral - developmental GUIDELINE=other:; QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eac86e4b0a7c65d1bf88b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/13631/7/9/3?documentUUID=f192f352-2a99-4d22-a4f4-5eedeba51287; YEAR=1984; ORIGINAL_YEAR=1984; STUDY_GROUP=ECHA IUCLID:15821845:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6f764d98ef900986b5df15ab3b431a04
NTP ICE acute oral 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP ICE acute oral LD50 =17300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11090; row=12514; data_type=In Vivo; mixture=Chemical; chemical_name=Xylitol; preferred_name=Xylitol; dtxsid=DTXSID7042514; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7042514; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =16500 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_11088; row=12515; data_type=In Vivo; mixture=Chemical; chemical_name=Xylitol; preferred_name=Xylitol; dtxsid=DTXSID7042514; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7042514; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 =14100 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM Hazardous Substances Data Bank (undated); record_id=acute_oral_11086; row=12516; data_type=In Vivo; mixture=Chemical; chemical_name=Xylitol; preferred_name=Xylitol; dtxsid=DTXSID7042514; url=https://pubchem.ncbi.nlm.nih.gov/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7042514; source_file=acute_oral.xlsx
NTP ICE acute oral LD50 >4000 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_11084; row=12517; data_type=In Vivo; mixture=Chemical; chemical_name=Xylitol; preferred_name=Xylitol; dtxsid=DTXSID7042514; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7042514; source_file=acute_oral.xlsx
openFDA substances 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier VCQ006KQ1E UNII - - - chemical -