NOAEL Studies Cosmetic Ingredient

Zinc Chloride NOAEL Studies

INCI: ZINC CHLORIDE

CAS: 7646-85-7

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 125 mg/kg bw/day rat oral 365 day Multigeneration Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 28 mg/kg bw/day rat oral 175 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 150 mg/kg bw/day mouse oral 5 day Developmental US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS_DB NOAEL 25 mg/kg bw/day rat oral 28 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
NTP_ICE_acute_inhalation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_inhalation LC50 2 mg/L - Inhalation - In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity sheet=Data; excel_row=1735; Record_ID=acute_inhalation_3571; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID2035013; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=2; Response_Unit=mg/L; Reference=NIOSH; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2035013
NTP_ICE_eye_irritation 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_eye_irritation GHS Classification 1 unitless Rabbit Ocular - In Vivo; Draize Eye Irritation/Corrosion Test sheet=Data; excel_row=956; Record_ID=eye_irritation_123; Data_Type=In Vivo; Mixture=Chemical; DTXSID=DTXSID2035013; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=GHS Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=ICCVAM 2006; URL=https://ntp.niehs.nih.gov/sites/default/files/iccvam/docs/ocutox_docs/oteval/otevalrpt.pdf; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2035013
ToxValDB_ECHA_IUCLID 5 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =2.5 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c35e4b096bca8771159; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25205/7/3/5?documentUUID=6c13c8f4-a720-4b62-bfa6-1ed716eb0aae; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815307_15815355_15815392_15815393_15815394_15815573_15815650_15815651_15815652_15815739_15815740_15815741:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8fc89c211f545610ca11b01163311fb5
ToxValDB_ECHA_IUCLID LEL =0.3 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c66e4b096bca8771cce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25205/7/3/5?documentUUID=6c13c8f4-a720-4b62-bfa6-1ed716eb0aae; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815307_15815355_15815392_15815393_15815394_15815573_15815650_15815651_15815652_15815739_15815740_15815741:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0f35a58f75b30ca3eec26c204f11b9e0
ToxValDB_ECHA_IUCLID LEL >0.5 mg/kg bw/day Rat oral - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61c66e4b096bca8771cce; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/25205/7/3/5?documentUUID=6c13c8f4-a720-4b62-bfa6-1ed716eb0aae; YEAR=2009; ORIGINAL_YEAR=2009; STUDY_GROUP=ECHA IUCLID_dup_Acute Toxicity Other Routes_15815307_15815355_15815392_15815393_15815394_15815573_15815650_15815651_15815652_15815739_15815740_15815741:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_885d64722ea9b3e8b20cc67b001d809b
ToxValDB_ECHA_IUCLID LOAEL =7.5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5da2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27599/7/9/2?documentUUID=9c1b3a5b-3fef-4295-b073-964b9456b67e; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: haematology|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|hematology|mortality/survival|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860508_15860883_15863056:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_933b5c43b9ced22b39b1011fe8fb8b1b
ToxValDB_ECHA_IUCLID NOAEL =15 mg/kg bw/day Rat oral - developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa71e4b0a7c65d1b5da2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/27599/7/9/2?documentUUID=9c1b3a5b-3fef-4295-b073-964b9456b67e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID_dup_Toxicity Reproduction_15860535_15861688:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_460b5c5ff5325b079a7143a9ef9befb9
ToxValDB_ECOTOX 58 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECOTOX LOEL =2 mg/kg bw/day Rat injection short-term; 28 days short-term LONG_REF=Toxicol. Environ. Chem.33(3-4): 231-237 Huerta,P., M.D. Blanco, R. Olmo, and J.M. Teijon Evolution of Weight and Zinc Level in Thymus and Spleen of Rats After Zinc Treatment 1991; TITLE=Evolution of Weight and Zinc Level in Thymus and Spleen of Rats After Zinc Treatment; AUTHOR=Huerta,P., M.D. Blanco, R. Olmo, and J.M. Teijon; DOI=10.1080/02772249109357764; QUALITY=Control type: Positive control; EXTERNAL_SOURCE_ID=85696; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Hemoglobin|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|hematology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594246_15594247:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dfddbcc4d5e52d646c42193110756ccd
ToxValDB_ECOTOX LOEL =1550 ppm Rat oral short-term; 28 days short-term LONG_REF=J. Nutr.100(8): 949-954 Huber,A.M., and S.N. Gershoff Effects of Dietary Zinc and Calcium on the Retention and Distribution of Zinc in Rats fed Semipurified Diets 1970; TITLE=Effects of Dietary Zinc and Calcium on the Retention and Distribution of Zinc in Rats fed Semipurified Diets; AUTHOR=Huber,A.M., and S.N. Gershoff; DOI=10.1093/jn/100.8.949; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=79324; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1970; ORIGINAL_YEAR=1970; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595106_15608073:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8881b3839b10f4b611f2b3f0f0ced4e9
ToxValDB_ECOTOX LOEL =0.1 mmol/kg Mouse injection short-term; 2 days short-term LONG_REF=Toxicol. Appl. Pharmacol.137(2): 307-315 Liu,Y., J. Liu, R.D. Palmiter, and C.D. Klaassen Metallothionein-I-Transgenic Mice are not Protected from Acute Cadmium-Metallothionein-Induced Nephrotoxicity 1996; TITLE=Metallothionein-I-Transgenic Mice are not Protected from Acute Cadmium-Metallothionein-Induced Nephrotoxicity; AUTHOR=Liu,Y., J. Liu, R.D. Palmiter, and C.D. Klaassen; DOI=10.1006/taap.1996.0085; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101770; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595211_15595212:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=451648a67eea36b1f161db34c03f4340
ToxValDB_ECOTOX LOEL =1 % w/v Mouse dermal short-term; 5 days short-term LONG_REF=Food Chem. Toxicol.29(1): 57-64 Lansdown,A.B.G. Interspecies Variations in Response to Topical Application of Selected Zinc Compounds 1991; TITLE=Interspecies Variations in Response to Topical Application of Selected Zinc Compounds; AUTHOR=Lansdown,A.B.G.; DOI=10.1016/0278-6915(91)90063-d; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=85721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Genetics: Mitotic index (# mitoses/total cells); TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15595286:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=824040265b85c0dbd478293e98ca4ed8
ToxValDB_ECOTOX LOEL =5 mg/kg bw/day Rat injection acute; 1 days acute LONG_REF=Toxicology207(2): 283-291 Brocardo,P.S., P. Pandolfo, R.N. Takahashi, A.L.S. Rodrigues, and A.L. Dafre Antioxidant Defenses and Lipid Peroxidation in the Cerebral Cortex and Hippocampus Following Acute Exposure to Malathion and/or Zinc Chloride 2005; TITLE=Antioxidant Defenses and Lipid Peroxidation in the Cerebral Cortex and Hippocampus Following Acute Exposure to Malathion and/or Zinc Chloride; AUTHOR=Brocardo,P.S., P. Pandolfo, R.N. Takahashi, A.L.S. Rodrigues, and A.L. Dafre; DOI=10.1016/j.tox.2004.09.012; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=80475; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2005; ORIGINAL_YEAR=2005; TOXICOLOGICAL_EFFECT=Biochemistry: Thiobarbituric acid reactive substances|Enzyme(s): Acetylcholinesterase; TOXICOLOGICAL_EFFECT_CATEGORY=neurotransmitter|other; STUDY_GROUP=ECOTOX:15595379:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5fe024b4092ad7a3c07f5d019b75c63e
ToxValDB_ECOTOX LOEL =400 ppm Rat oral short-term; 7 days short-term LONG_REF=Scand. J. Gastroenterol.34:689-695 Tran,C.D., R.N. Butler, G.S. Howarth, J.C. Philcox, A.M. Rofe, and P. Coyle Regional Distribution and Localization of Zinc and Metallothionein in the Intestine of Rats Fed Diets Differing in Zinc Content 1999; TITLE=Regional Distribution and Localization of Zinc and Metallothionein in the Intestine of Rats Fed Diets Differing in Zinc Content; AUTHOR=Tran,C.D., R.N. Butler, G.S. Howarth, J.C. Philcox, A.M. Rofe, and P. Coyle; DOI=10.1080/003655299750025895; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=78736; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595589_15598234_15607887_15608518:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=988b29dcd7b7766e22c55ca981a412d8
ToxValDB_ECOTOX LOEL =28 mg/kg bw/day Mouse injection acute; 0.0833 days acute LONG_REF=Pharmacol. Res.32(4): 233-236 Tan,B.K.H., B.H. Bay, K.H. Sit, K.Y. Sim, and A. Hsu Acute Zinc Administration Prolongs Hexobarbitone-Induced Sleeping Time in C57/6J Mice 1995; TITLE=Acute Zinc Administration Prolongs Hexobarbitone-Induced Sleeping Time in C57/6J Mice; AUTHOR=Tan,B.K.H., B.H. Bay, K.H. Sit, K.Y. Sim, and A. Hsu; DOI=10.1016/s1043-6618(05)80027-1; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86066; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595855_15599643:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1c33ee6699860b48973567294fdac7d2
ToxValDB_ECOTOX LOEL =0.12 mg/kg bw/day Mouse injection short-term; 3 days short-term LONG_REF=Indian J. Exp. Biol.29(9): 823-825 Khan,S., M.A. Khan, D. Bhatnagar, P. Yadav, and S. Sarkar Zinc Protection Against Lipid Peroxidation from Cadmium 1991; TITLE=Zinc Protection Against Lipid Peroxidation from Cadmium; AUTHOR=Khan,S., M.A. Khan, D. Bhatnagar, P. Yadav, and S. Sarkar; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=82634; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Enzyme(s): Catalase|Physiology: Lipid peroxidation; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595954_15596720:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=924e7f6f319f30ed0cca33b1401a6eb6
ToxValDB_ECOTOX LOEL =10000 ppm Mouse oral short-term; 21 days short-term LONG_REF=Comp. Biochem. Physiol. C Comp. Pharmacol. Toxicol.132(1): 53-60 Pettersen,A.J., R.A. Andersen, and K.E. Zachariassen Effects of Dietary Intake of Trace Metals on Tissue Contents of Sodium and Calcium in Mice (Mus musculus) 2002; TITLE=Effects of Dietary Intake of Trace Metals on Tissue Contents of Sodium and Calcium in Mice (Mus musculus); AUTHOR=Pettersen,A.J., R.A. Andersen, and K.E. Zachariassen; DOI=10.1016/s1532-0456(02)00044-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76901; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Calcium content|Biochemistry: Sodium content; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595707_15596109:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4da94a10f937cd395ebeb1c77a009fcc
ToxValDB_ECOTOX LOEL =400 umol/kg/day Mouse injection short-term; 3 days short-term LONG_REF=Arch. Toxicol.66(2): 145-148 Satoh,M., A. Naganuma, and N. Imura Effect of Preinduction of Metallothionein on Paraquat Toxicity in Mice 1992; TITLE=Effect of Preinduction of Metallothionein on Paraquat Toxicity in Mice; AUTHOR=Satoh,M., A. Naganuma, and N. Imura; DOI=10.1007/BF02342510; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=106621; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1992; ORIGINAL_YEAR=1992; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596135_15598965:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2e4cde429311c4bc821fc94c4d8a58e9
ToxValDB_ECOTOX LOEL =0.2 mmol/kg Rat injection short-term; 2 days short-term LONG_REF=Biochem. J. (Lond.)245(2): 339-345 Goering,P.L., and B.A. Fowler Metal Constitution of Metallothionein Influences Inhibition of delta Aminolaevulinic Acid Dehydratase (Porphobilinogen Synthase) by Lead 1987; TITLE=Metal Constitution of Metallothionein Influences Inhibition of delta Aminolaevulinic Acid Dehydratase (Porphobilinogen Synthase) by Lead; AUTHOR=Goering,P.L., and B.A. Fowler; DOI=10.1042/bj2450339; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101265; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Enzyme(s): (delta)-Aminolevulinic acid dehydrogenase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15596414:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3fa26e73d600b29672165b996b6205cd
ToxValDB_ECOTOX LOEL =60 mg/L Rat oral chronic; 182.64 days chronic LONG_REF=Toxicology237(1-3): 89-103 Brzoska,M.M., J. Rogalska, M. Galazyn-Sidorczuk, M. Jurczuk, A. Roszczenko, E. Kulikowska-Karpinska, and J. Moniuszko-J Effect of Zinc Supplementation on Bone Metabolism in Male Rats Chronically Exposed to Cadmium 2007; TITLE=Effect of Zinc Supplementation on Bone Metabolism in Male Rats Chronically Exposed to Cadmium; AUTHOR=Brzoska,M.M., J. Rogalska, M. Galazyn-Sidorczuk, M. Jurczuk, A. Roszczenko, E. Kulikowska-Karpinska, and J. Moniuszko-J; DOI=10.1016/j.tox.2007.05.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101767; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Physiology: Zinc excretion; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596430_15596431_15606040:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=dd79e109be61b381ae76ecd9080be957
ToxValDB_ECOTOX LOEL =1 mmol/kg Rat injection acute; 1 days acute LONG_REF=Toxicology104(1-3): 25-33 Iszard,M.B., J. Liu, and C.D. Klaassen Effect of Several Metallothionein Inducers on Oxidative Stress Defense Mechanisms in Rats 1995; TITLE=Effect of Several Metallothionein Inducers on Oxidative Stress Defense Mechanisms in Rats; AUTHOR=Iszard,M.B., J. Liu, and C.D. Klaassen; DOI=10.1016/0300-483x(95)03118-y; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=84485; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1995; ORIGINAL_YEAR=1995; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein|Enzyme(s): Catalase|Hormone(s): 15 Beta-hydroxytestosterone; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|other; STUDY_GROUP=ECOTOX:15596796:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=d711b106361cb35a9af5edcdecaff7e3
ToxValDB_ECOTOX LOEL =0.00138 mol/kg bw Mouse oral subchronic; 84 days subchronic LONG_REF=Arch. Environ. Health57(2): 98-102 Afonne,O.J., O.E. Orisakwe, E. Obi, C.E. Dioka, and G.I. Ndubuka Nephrotoxic Actions of Low-Dose Mercury in Mice: Protection by Zinc 2002; TITLE=Nephrotoxic Actions of Low-Dose Mercury in Mice: Protection by Zinc; AUTHOR=Afonne,O.J., O.E. Orisakwe, E. Obi, C.E. Dioka, and G.I. Ndubuka; DOI=10.1080/00039890209602923; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100805; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption|Growth: Weight gain|Morphology: Organ weight in relationship to body weight|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|food and/or water consumption|organ weight|other; STUDY_GROUP=ECOTOX:15597908:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=95c43dd127902db504392dbb92fcd78d
ToxValDB_ECOTOX LOEL =14 mg/kg bw/day Mouse injection short-term; 21 days short-term LONG_REF=Okajimas Folia Anat. Jpn.74(6): 279-292 Bay,B.H., M.C.W. Wang, and G.W.C. Yip Effect of Intraperitoneal Administration of Zinc on C57/6J Mouse Liver-A Light Microscopic Study 1998; TITLE=Effect of Intraperitoneal Administration of Zinc on C57/6J Mouse Liver-A Light Microscopic Study; AUTHOR=Bay,B.H., M.C.W. Wang, and G.W.C. Yip; DOI=10.2535/ofaj1936.74.6_279; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86895; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Cell(s): Area|Cell(s): Circumference|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15597962_15607171:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=477e6971179769d3897ddfae23afe7d9
ToxValDB_ECOTOX LOEL =1000 ppm Rat oral short-term; 7 days short-term LONG_REF=Scand. J. Gastroenterol.34:689-695 Tran,C.D., R.N. Butler, G.S. Howarth, J.C. Philcox, A.M. Rofe, and P. Coyle Regional Distribution and Localization of Zinc and Metallothionein in the Intestine of Rats Fed Diets Differing in Zinc Content 1999; TITLE=Regional Distribution and Localization of Zinc and Metallothionein in the Intestine of Rats Fed Diets Differing in Zinc Content; AUTHOR=Tran,C.D., R.N. Butler, G.S. Howarth, J.C. Philcox, A.M. Rofe, and P. Coyle; DOI=10.1080/003655299750025895; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=78736; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595589_15598234_15607887_15608518:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=84460c5757bb1505f415534e15233b6d
ToxValDB_ECOTOX LOEL =0.5 % Mouse oral short-term; 30.44 days short-term LONG_REF=Mutat. Res.68:163-168 Deknudt,G., and G.B. Gerber Chromosomal Aberrations in Bone-Marrow Cells of Mice Given a Normal or a Calcium-Deficient Diet Supplemented with Various Heavy Metals 1979; TITLE=Chromosomal Aberrations in Bone-Marrow Cells of Mice Given a Normal or a Calcium-Deficient Diet Supplemented with Various Heavy Metals; AUTHOR=Deknudt,G., and G.B. Gerber; DOI=10.1016/0165-1218(79)90144-7; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=59393; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1979; ORIGINAL_YEAR=1979; TOXICOLOGICAL_EFFECT=Biochemistry: Calcium content|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599617_15599919:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=43dee7ef6f6bbb11ba0ea7340c5aa8b4
ToxValDB_ECOTOX LOEL =240 mg/L Rat oral short-term; 14 days short-term LONG_REF=Pol. J. Pharmacol. Pharm.41(3): 281-289 Kulikowska,E., J. Moniuszko-Jakoniuk, and K. Miniuk The Effect of Zinc on the Toxic Action of Lead After Administration of Ethanol to Rats 1989; TITLE=The Effect of Zinc on the Toxic Action of Lead After Administration of Ethanol to Rats; AUTHOR=Kulikowska,E., J. Moniuszko-Jakoniuk, and K. Miniuk; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86210; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Lead content; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599677_15604854:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b4e42edb494f3e623d3f03f445d474b7
ToxValDB_ECOTOX LOEL =4.6 mmol Rat oral short-term; 11 days short-term LONG_REF=Toxicology183(1-3): 199-209 Flaig,K.H., K. Schumann, and B. Elsenhans Jejunal Transfer Rates of 109Cadmium Chloride Increase in Rats In Vitro and In Vivo After Oral Pretreatment with Cadmium or Zinc Chloride 2003; TITLE=Jejunal Transfer Rates of 109Cadmium Chloride Increase in Rats In Vitro and In Vivo After Oral Pretreatment with Cadmium or Zinc Chloride; AUTHOR=Flaig,K.H., K. Schumann, and B. Elsenhans; DOI=10.1016/s0300-483x(02)00547-4; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84312; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Accumulation: Uptake; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15599929_15605480:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=41e71c95d617117525221c7ab3cea9bf
ToxValDB_ECOTOX LOEL =20 mg/kg bw/day Rat injection short-term; 4 days short-term LONG_REF=Toxicology179(1-2): 85-93 Ali,M.M., E. Frei, J. Straub, A. Breuer, and M. Wiessler Induction of Metallothionein by Zinc Protects from Daunorubicin Toxicity in Rats 2002; TITLE=Induction of Metallothionein by Zinc Protects from Daunorubicin Toxicity in Rats; AUTHOR=Ali,M.M., E. Frei, J. Straub, A. Breuer, and M. Wiessler; DOI=10.1016/s0300-483x(02)00322-0; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85438; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein|Genetics: Metallothionein-I mRNA; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600328_15605351:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=96fda0f330c2d164856898e748704c5a
ToxValDB_ECOTOX LOEL =4 mg/kg bw/day Rat injection short-term; 6 days short-term LONG_REF=Experientia44(9): 754-755 Wormser,U., and D. Calp Metallothionein Induction by Cadmium and Zinc in Rat Secretory Organs 1988; TITLE=Metallothionein Induction by Cadmium and Zinc in Rat Secretory Organs; AUTHOR=Wormser,U., and D. Calp; DOI=10.1007/BF01959151; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85353; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602774_15607144_15607145:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=4a482ad38d166a669c093ebfb5a8c19c
ToxValDB_ECOTOX LOEL =0.01 mM Rat injection acute; 0.0208 days acute LONG_REF=J. Neurosci. Res.75(2): 225-229 Takeda,A., A. Minami, Y. Seki, and N. Oku Differential Effects of Zinc on Glutamatergic and GABAergic Neurotransmitter Systems in the Hippocampus 2004; TITLE=Differential Effects of Zinc on Glutamatergic and GABAergic Neurotransmitter Systems in the Hippocampus; AUTHOR=Takeda,A., A. Minami, Y. Seki, and N. Oku; DOI=10.1002/jnr.10846; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=101261; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Biochemistry: Glutamate; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX:15603444:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bf9baa747d7ef54b6910c3f8f2099c46
ToxValDB_ECOTOX LOEL =6.5 mg/kg bw/day Rat injection short-term; 3 days short-term LONG_REF=J. Toxicol. Environ. Health28(1): 39-51 Jaw,S., and E.H. Jeffery Role of Metallothionein in Biliary Metal Excretion 1989; TITLE=Role of Metallothionein in Biliary Metal Excretion; AUTHOR=Jaw,S., and E.H. Jeffery; DOI=10.1080/15287398909531327; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=84828; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15604098:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=35368389619cf266be1b806184e7e303
ToxValDB_ECOTOX LOEL =27 mg/kg bw/day Rat injection short-term; 5 days short-term LONG_REF=Life Sci.81(16): 1264-1271 Peixoto,N.C., M.A. Serafim, E.M.M. Flores, M.J. Bebianno, and M.E. Pereira Metallothionein, Zinc, and Mercury Levels in Tissues of Young Rats Exposed to Zinc and Subsequently to Mercury 2007; TITLE=Metallothionein, Zinc, and Mercury Levels in Tissues of Young Rats Exposed to Zinc and Subsequently to Mercury; AUTHOR=Peixoto,N.C., M.A. Serafim, E.M.M. Flores, M.J. Bebianno, and M.E. Pereira; DOI=10.1016/j.lfs.2007.08.038; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101884; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15604400:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=61102887ef4634e30cfda3270e1f9bb8
ToxValDB_ECOTOX LOEL =530 ppm Rat oral short-term; 10 days short-term LONG_REF=Toxicol. Appl. Pharmacol.70:43-48 Oishi,S., and K. Hiraga Testicular Atrophy Induced by Di-2-Ethylhexyl Phthalate: Effect of Zinc Supplement 1983; TITLE=Testicular Atrophy Induced by Di-2-Ethylhexyl Phthalate: Effect of Zinc Supplement; AUTHOR=Oishi,S., and K. Hiraga; DOI=10.1016/0041-008x(83)90177-1; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=67818; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1983; ORIGINAL_YEAR=1983; TOXICOLOGICAL_EFFECT=Accumulation: Residue; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606462_15606463:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=58892f296a2951b3a83bf738491a1d9c
ToxValDB_ECOTOX LOEL =8 mg/kg bw/day Rat injection short-term; 6 days short-term LONG_REF=Experientia44(9): 754-755 Wormser,U., and D. Calp Metallothionein Induction by Cadmium and Zinc in Rat Secretory Organs 1988; TITLE=Metallothionein Induction by Cadmium and Zinc in Rat Secretory Organs; AUTHOR=Wormser,U., and D. Calp; DOI=10.1007/BF01959151; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85353; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15602774_15607144_15607145:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5e8cfe573f618f98ee5d561d178dc8df
ToxValDB_ECOTOX LOEL =13 umol/kg/day Rat injection short-term; 1.5 days short-term LONG_REF=Toxicol. Appl. Pharmacol.55(2): 393-402 Eaton,D.L., N.H. Stacey, K.L. Wong, and C.D. Klaassen Dose-Response Effects of Various Metal Ions on Rat Liver Metallothionein, Glutathione, Heme Oxygenase, and Cytochrome P-450 1980; TITLE=Dose-Response Effects of Various Metal Ions on Rat Liver Metallothionein, Glutathione, Heme Oxygenase, and Cytochrome P-450; AUTHOR=Eaton,D.L., N.H. Stacey, K.L. Wong, and C.D. Klaassen; DOI=10.1016/0041-008x(80)90101-5; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600372_15610468:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f830f90bcf6bd8c2b44cb7e93a1de9d4
ToxValDB_ECOTOX LOEL =100 mg/kg bw/day Rat oral short-term; 30 days short-term LONG_REF=- | Methods Find. Exp. Clin. Pharmacol.15(10): 715-719 Tantcheva,L., T. Stoytchev, E. Mehandjieva, and L. Tivcheva Liver and Kidney Monooxygenase Activity in Rats Subchronically Treated with Zn and Pb Salts and Their Combination 1993; TITLE=Liver and Kidney Monooxygenase Activity in Rats Subchronically Treated with Zn and Pb Salts and Their Combination; AUTHOR=Tantcheva,L., T. Stoytchev, E. Mehandjieva, and L. Tivcheva; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=79639; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=Enzyme(s): Aniline hydroxylase|Enzyme(s): N-Demethylase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX:15613145:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=5b8719172ce71ca117a7024e3f395743
ToxValDB_ECOTOX LOEL =16.5 mg/kg bw/day Mouse oral short-term; 21 days short-term LONG_REF=- | Cytologia53(4): 793-799 Giri,A.K., T.S. Bandyopadhyay, A. Mukherjee, G. Talukder, and A. Sharma Effects of Vitamin C and Vitamin A on Post Chromosomal Aberration In Vivo Induced by Metanil Yellow and Zinc Chloride 1988; TITLE=Effects of Vitamin C and Vitamin A on Post Chromosomal Aberration In Vivo Induced by Metanil Yellow and Zinc Chloride; AUTHOR=Giri,A.K., T.S. Bandyopadhyay, A. Mukherjee, G. Talukder, and A. Sharma; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86033; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Genetics: Chromosomal aberrations; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15613331:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=8801f5528cf9e8cf89e5babf63582c91
ToxValDB_ECOTOX LOEL =5.5 mg/kg bw/day Rat oral short-term; 28 days short-term LONG_REF=- | Folia Histochem. Cytobiol.37(2): 113-114 Zaporowska,H., and A. Scibior Activity of Neutrophilic Granulocytes in Rats Following Intoxication with Vanadium and Zinc 1999; TITLE=Activity of Neutrophilic Granulocytes in Rats Following Intoxication with Vanadium and Zinc; AUTHOR=Zaporowska,H., and A. Scibior; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=62121; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1999; ORIGINAL_YEAR=1999; TOXICOLOGICAL_EFFECT=Biochemistry: increased alkaline phosphatase and phagocytic activity of nuetrophils| Feeding behavior: Increase in food and water intake; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption|multiple; STUDY_GROUP=ECOTOX:15613332:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; Source overall passed QC, and this record was expert reviewed and revised from ECOTOX source; QC_STATUS=pass; SOURCE_HASH=65b79e62c4d828073fe8bad704cf4b22
ToxValDB_ECOTOX NOEL =1 mg/kg bw/day Rat injection short-term; 30 days short-term LONG_REF=Toxicol. Lett.10(2-3): 163-168 Shukla,G.S., and S.V. Chandra Effect of Interaction of Mn2+ with Zn2+, Hg2+ and Cd2+ on Some Neurochemicals in Rats 1982; TITLE=Effect of Interaction of Mn2+ with Zn2+, Hg2+ and Cd2+ on Some Neurochemicals in Rats; AUTHOR=Shukla,G.S., and S.V. Chandra; DOI=10.1016/0378-4274(82)90069-8; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=100578; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1982; ORIGINAL_YEAR=1982; TOXICOLOGICAL_EFFECT=Biochemistry: 5-Hydroxyindole acetic acid|Hormone(s): Dopamine|Hormone(s): Norepinephrine|Hormone(s): Serotonin; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|neurotransmitter; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594138_15595489:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b41303416b45eab6c9f1e7b70aad9aa8
ToxValDB_ECOTOX NOEL =5 mg/kg bw/day Rat injection short-term; 4 days short-term LONG_REF=Toxicol. Sci.97(1): 140-148 Brocardo,P.S., F. Assini, J.L. Franco, P. Pandolfo, Y.M.R. Muller, R.N. Takahashi, A.L. Dafre, and A.L.S. Rodriques Zinc Attenuates Malathion-Induced Depressant-like Behavior and Confers Neuroprotection in the Rat Brain 2007; TITLE=Zinc Attenuates Malathion-Induced Depressant-like Behavior and Confers Neuroprotection in the Rat Brain; AUTHOR=Brocardo,P.S., F. Assini, J.L. Franco, P. Pandolfo, Y.M.R. Muller, R.N. Takahashi, A.L. Dafre, and A.L.S. Rodriques; DOI=10.1093/toxsci/kfm024; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=96652; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Biochemistry: Glutathione (reduced glutathione)|Biochemistry: Thiobarbituric acid reactive substances|Enzyme(s): Acetylcholinesterase|Enzyme(s): Glucose-6-phosphate dehydrogenase|Enzyme(s): Glutathione peroxidase|Enzyme(s): Glutathione reductase|Enzyme(s): Glutathione S-transferase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity|neurotransmitter|other; STUDY_GROUP=ECOTOX:15594382:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ea7ff8a4a9b318a4726c1582f44bb954
ToxValDB_ECOTOX NOEL =5 % Rat dermal acute; 1 days acute LONG_REF=Bull. Environ. Contam. Toxicol.46(2): 249-254 Wormser,U., and S. BenZakine Increased Levels of Hepatic and Renal Metallothionein in the Rat and Guinea Pig After Percutaneous Application of Zinc Chloride 1991; TITLE=Increased Levels of Hepatic and Renal Metallothionein in the Rat and Guinea Pig After Percutaneous Application of Zinc Chloride; AUTHOR=Wormser,U., and S. BenZakine; DOI=10.1007/BF01691945; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85849; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15594448:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1567c7366ec67ccf82772b9e663fc933
ToxValDB_ECOTOX NOEL =13 mg/kg bw/day Rat injection short-term; 10 days reproduction developmental LONG_REF=Chemosphere72:1327-1332 Peixoto,N.C., L.C. Rocha, D.P. Moraes, M.J. Bebianno, V.L. Dressler, E.M.M. Flores, and M.E. Pereira Changes in Levels of Essential Elements in Suckling Rats Exposed to Zinc and Mercury 2008; TITLE=Changes in Levels of Essential Elements in Suckling Rats Exposed to Zinc and Mercury; AUTHOR=Peixoto,N.C., L.C. Rocha, D.P. Moraes, M.J. Bebianno, V.L. Dressler, E.M.M. Flores, and M.E. Pereira; DOI=10.1016/j.chemosphere.2008.04.027; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=103057; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2008; ORIGINAL_YEAR=2008; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Copper (Cu) content|Biochemistry: Iron content|Biochemistry: Magnesium (Mg) content|Biochemistry: Manganese (Mn) content|Biochemistry: Mercury concentration; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594524_15594979:M/F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2914e2bdaf0df370975efa431ced9dd6
ToxValDB_ECOTOX NOEL =8.5 mg/org-day Rat oral short-term; 14 days short-term LONG_REF=Food Chem. Toxicol.39(7): 729-737 Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, M. Galazyn-Sidorczuk, and J. Rogalska The Effect of Zinc Supply on Cadmium-Induced Changes in the Tibia of Rats 2001; TITLE=The Effect of Zinc Supply on Cadmium-Induced Changes in the Tibia of Rats; AUTHOR=Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, M. Galazyn-Sidorczuk, and J. Rogalska; DOI=10.1016/s0278-6915(01)00007-2; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76900; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Cadmium content|Biochemistry: Calcium content|Biochemistry: Carbon content|Biochemistry: Copper (Cu) content|Biochemistry: Iron content|Biochemistry: Magnesium (Mg) content|Biochemistry: Mineral content|Biochemistry: Water content|Morphology: Ratio|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594567_15608031:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=8a2908f397e7461fe578f5455a05aa80
ToxValDB_ECOTOX NOEL =0.1 mmol/kg Rat injection short-term; 2 days short-term LONG_REF=Histochem. J.23(2): 75-82 Gunther,T., R. Gossrau, J. Vormann, and M. Ruhnke Protection Against Salicylate-Induced Hepatic Injury by Zinc. A Histochemical and Biochemical Study 1991; TITLE=Protection Against Salicylate-Induced Hepatic Injury by Zinc. A Histochemical and Biochemical Study; AUTHOR=Gunther,T., R. Gossrau, J. Vormann, and M. Ruhnke; DOI=10.1007/BF01047111; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86069; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Calcium content|Biochemistry: Glycogen|Biochemistry: Iron content|Biochemistry: Magnesium (Mg) content|Biochemistry: Metallothionein|Biochemistry: Protein content|Biochemistry: Transferrin|Enzyme(s): Alanine transaminase (ALT)|Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical chemistry|hematology|other|urinalysis; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594801_15603328:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=850b8ea3460ae6111cc91268b40909f4
ToxValDB_ECOTOX NOEL =13.4 mg/L Rat oral chronic; 189 days chronic LONG_REF=J. Am. Coll. Toxicol.4(6): 321-330 Kurokawa,Y., M. Matsushima, T. Imazawa, N. Takamura, M. Takahashi, and Y. Hayashi Promoting Effect of Metal Compounds on Rat Renal Tumorigenesis 1985; TITLE=Promoting Effect of Metal Compounds on Rat Renal Tumorigenesis; AUTHOR=Kurokawa,Y., M. Matsushima, T. Imazawa, N. Takamura, M. Takahashi, and Y. Hayashi; DOI=10.3109/10915818509078695; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=78038; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594876_15598331:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2e1ae23e0d15ebd80628f6192e196434
ToxValDB_ECOTOX NOEL =100 mg/L Mouse oral subchronic; 42 days subchronic LONG_REF=Parasitol. Res.94(1): 74-81 Chen,C.H., Y.L. Huang, and C.M. Yen The Influence of Zinc in Mice on Infection with Angiostrongylus cantonensis 2004; TITLE=The Influence of Zinc in Mice on Infection with Angiostrongylus cantonensis; AUTHOR=Chen,C.H., Y.L. Huang, and C.M. Yen; DOI=10.1007/s00436-004-1176-7; QUALITY=Control type: Control outside of primary exposure system; EXTERNAL_SOURCE_ID=101266; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2004; ORIGINAL_YEAR=2004; TOXICOLOGICAL_EFFECT=Immunological: Parasitic infection; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594938_15598674:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5f01a116261a94c8bf499b901d07bf2e
ToxValDB_ECOTOX NOEL =8 mg/org-day Rat oral subchronic; 84 days subchronic LONG_REF=Food Chem. Toxicol.39(7): 729-737 Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, M. Galazyn-Sidorczuk, and J. Rogalska The Effect of Zinc Supply on Cadmium-Induced Changes in the Tibia of Rats 2001; TITLE=The Effect of Zinc Supply on Cadmium-Induced Changes in the Tibia of Rats; AUTHOR=Brzoska,M.M., J. Moniuszko-Jakoniuk, M. Jurczuk, M. Galazyn-Sidorczuk, and J. Rogalska; DOI=10.1016/s0278-6915(01)00007-2; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76900; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Cadmium content|Biochemistry: Calcium content|Biochemistry: Carbon content|Biochemistry: Copper (Cu) content|Biochemistry: Magnesium (Mg) content|Biochemistry: Mineral content|Biochemistry: Water content|Morphology: Ratio|Morphology: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595030_15597048:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=f40530119889b26b85d5a80fdf82796d
ToxValDB_ECOTOX NOEL =0.05 mmol/kg Mouse injection short-term; 2 days short-term LONG_REF=Toxicol. Appl. Pharmacol.137(2): 307-315 Liu,Y., J. Liu, R.D. Palmiter, and C.D. Klaassen Metallothionein-I-Transgenic Mice are not Protected from Acute Cadmium-Metallothionein-Induced Nephrotoxicity 1996; TITLE=Metallothionein-I-Transgenic Mice are not Protected from Acute Cadmium-Metallothionein-Induced Nephrotoxicity; AUTHOR=Liu,Y., J. Liu, R.D. Palmiter, and C.D. Klaassen; DOI=10.1006/taap.1996.0085; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101770; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595211_15595212:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=24dd1257d9941a4df0b5b12c566ba0b4
ToxValDB_ECOTOX NOEL =0.5 mg/kg bw/day Rat injection short-term; 2 days short-term LONG_REF=Environ. Res.37(1): 192-204 Chakrabarti,S., and J. Brodeur Influence of Zinc Chloride on the Metabolism and Hepatotoxicity of Bromobenzene in Rats 1985; TITLE=Influence of Zinc Chloride on the Metabolism and Hepatotoxicity of Bromobenzene in Rats; AUTHOR=Chakrabarti,S., and J. Brodeur; DOI=10.1016/0013-9351(85)90057-x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85903; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Biochemistry: Microsomal proteins|Enzyme(s): Aminopyrine n-demethylase|Enzyme(s): Aniline hydroxylase|Enzyme(s): Cytochrome P-450|Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595647_15596057:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=88447b3f1ccb792bea0fe57bc3e83e63
ToxValDB_ECOTOX NOEL =20000 ppm Mouse oral short-term; 21 days short-term LONG_REF=Comp. Biochem. Physiol. C Comp. Pharmacol. Toxicol.132(1): 53-60 Pettersen,A.J., R.A. Andersen, and K.E. Zachariassen Effects of Dietary Intake of Trace Metals on Tissue Contents of Sodium and Calcium in Mice (Mus musculus) 2002; TITLE=Effects of Dietary Intake of Trace Metals on Tissue Contents of Sodium and Calcium in Mice (Mus musculus); AUTHOR=Pettersen,A.J., R.A. Andersen, and K.E. Zachariassen; DOI=10.1016/s1532-0456(02)00044-3; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=76901; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Biochemistry: Calcium content|Biochemistry: Sodium content; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595707_15596109:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bca3438594590e428c9a7c3f84c697e4
ToxValDB_ECOTOX NOEL =1150 ppm Rat oral short-term; 8.06 days short-term LONG_REF=J. Nutr.118:1385-1390 Jaw,S., and E.H. Jeffery The Effect of Dietary Zinc Status on Biliary Metal Excretion of Rats 1988; TITLE=The Effect of Dietary Zinc Status on Biliary Metal Excretion of Rats; AUTHOR=Jaw,S., and E.H. Jeffery; DOI=10.1093/jn/118.11.1385; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=78747; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1988; ORIGINAL_YEAR=1988; TOXICOLOGICAL_EFFECT=Accumulation: Elimination; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15595912_15610536:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=1ac5b9bb6cc738d9669a1ccbcd31291a
ToxValDB_ECOTOX NOEL =250 umol/kg bw Rat injection short-term; 3 days short-term LONG_REF=Pharmacology38(3): 159-166 Rosenberg,D.W., and A. Kappas Comparative Ability of Exogenously Administered Metals to Alter Tissue Levels and Urinary Output of Copper and Zinc 1989; TITLE=Comparative Ability of Exogenously Administered Metals to Alter Tissue Levels and Urinary Output of Copper and Zinc; AUTHOR=Rosenberg,D.W., and A. Kappas; DOI=10.1159/000138533; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101259; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1989; ORIGINAL_YEAR=1989; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Copper (Cu) content|Physiology: Copper excretion; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596429_15603305:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=b891b997a095cae708bed742b07c4ee6
ToxValDB_ECOTOX NOEL =30 mg/L Rat oral chronic; 182.64 days chronic LONG_REF=Toxicology237(1-3): 89-103 Brzoska,M.M., J. Rogalska, M. Galazyn-Sidorczuk, M. Jurczuk, A. Roszczenko, E. Kulikowska-Karpinska, and J. Moniuszko-J Effect of Zinc Supplementation on Bone Metabolism in Male Rats Chronically Exposed to Cadmium 2007; TITLE=Effect of Zinc Supplementation on Bone Metabolism in Male Rats Chronically Exposed to Cadmium; AUTHOR=Brzoska,M.M., J. Rogalska, M. Galazyn-Sidorczuk, M. Jurczuk, A. Roszczenko, E. Kulikowska-Karpinska, and J. Moniuszko-J; DOI=10.1016/j.tox.2007.05.001; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=101767; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Physiology: Zinc excretion; STUDY_GROUP=ECOTOX_dup_EPA ORD_15596430_15596431_15606040:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2eda03f17d7c7d8643fa9758c55ef8d8
ToxValDB_ECOTOX NOEL =500 mg/L Rat oral short-term; 28 days short-term LONG_REF=Environ. Res.37(1): 192-204 Chakrabarti,S., and J. Brodeur Influence of Zinc Chloride on the Metabolism and Hepatotoxicity of Bromobenzene in Rats 1985; TITLE=Influence of Zinc Chloride on the Metabolism and Hepatotoxicity of Bromobenzene in Rats; AUTHOR=Chakrabarti,S., and J. Brodeur; DOI=10.1016/0013-9351(85)90057-x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85903; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Enzyme(s): Aniline hydroxylase|Enzyme(s): Cytochrome P-450|Growth: Weight|Morphology: Organ weight in relationship to body weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|enzyme activity|organ weight; STUDY_GROUP=ECOTOX:15596446:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=5a42eb1a220af9c0cae9b7d8755add60
ToxValDB_ECOTOX NOEL =100 umol/g org European Rabbit injection acute; 1 days acute LONG_REF=Mutat. Res.369(3-4): 233-241 Cai,L., and M.G. Cherian Adaptive Response to Ionizing Radiation-Induced Chromosome Aberrations in Rabbit Lymphocytes: Effect of Pre-Exposure to Zinc, and Copper Salts 1996; TITLE=Adaptive Response to Ionizing Radiation-Induced Chromosome Aberrations in Rabbit Lymphocytes: Effect of Pre-Exposure to Zinc, and Copper Salts; AUTHOR=Cai,L., and M.G. Cherian; DOI=10.1016/s0165-1218(96)90028-2; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=86016; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1996; ORIGINAL_YEAR=1996; TOXICOLOGICAL_EFFECT=Genetics: Chromosomal aberrations|Genetics: Chromosomal breaks; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15596463:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=23f3620f0ff9986da0ce732a37ab6ab1
ToxValDB_ECOTOX NOEL =8 mg/kg bw/day Mouse injection short-term; 3 days developmental LONG_REF=Toxicol. Sci.76(1): 162-170 Fernandez,E.L., A.L. Gustafson, M. Andersson, B. Hellman, and L. Dencker Cadmium-Induced Changes in Apoptotic Gene Expression Levels and DNA Damage in Mouse Embryos Are Blocked by Zinc 2003; TITLE=Cadmium-Induced Changes in Apoptotic Gene Expression Levels and DNA Damage in Mouse Embryos Are Blocked by Zinc; AUTHOR=Fernandez,E.L., A.L. Gustafson, M. Andersson, B. Hellman, and L. Dencker; DOI=10.1093/toxsci/kfg208; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=84481; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2003; ORIGINAL_YEAR=2003; TOXICOLOGICAL_EFFECT=Development: Teratogenic measurements|Morphology: Length|Morphology: Quantity; TOXICOLOGICAL_EFFECT_CATEGORY=development|other; STUDY_GROUP=ECOTOX:15599063:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=e35c3add93d7ed18c825c25778206e9c
ToxValDB_ECOTOX NOEL =10 mg/kg bw/day Rat injection short-term; 3 days short-term LONG_REF=Environ. Res.37(1): 192-204 Chakrabarti,S., and J. Brodeur Influence of Zinc Chloride on the Metabolism and Hepatotoxicity of Bromobenzene in Rats 1985; TITLE=Influence of Zinc Chloride on the Metabolism and Hepatotoxicity of Bromobenzene in Rats; AUTHOR=Chakrabarti,S., and J. Brodeur; DOI=10.1016/0013-9351(85)90057-x; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85903; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1985; ORIGINAL_YEAR=1985; TOXICOLOGICAL_EFFECT=Enzyme(s): Alanine transaminase (ALT)|Enzyme(s): Glutamic-oxaloacetic transaminase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|enzyme activity; STUDY_GROUP=ECOTOX:15599476:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=0c554fc4aeddf757e4b553bdcccbe1e4
ToxValDB_ECOTOX NOEL =27 mg/kg bw/day Rat injection short-term; 13 days reproduction developmental LONG_REF=Ecotoxicol. Environ. Saf.66(3): 441-446 Peixoto,N.C., and M.E. Pereira Effectiveness of ZnCl2 in Protecting Against Nephrotoxicity Induced by HgCl2 in Newborn Rats 2007; TITLE=Effectiveness of ZnCl2 in Protecting Against Nephrotoxicity Induced by HgCl2 in Newborn Rats; AUTHOR=Peixoto,N.C., and M.E. Pereira; DOI=10.1016/j.ecoenv.2006.02.012; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2007; ORIGINAL_YEAR=2007; TOXICOLOGICAL_EFFECT=Biochemistry: Creatinine|Enzyme(s): Lactate dehydrogenase; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|urinalysis; STUDY_GROUP=ECOTOX:15599503:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c0c2990a8dd316b3ff2ad3e0b9d9862b
ToxValDB_ECOTOX NOEL =200 umol/kg/day Rat injection short-term; 1.5 days short-term LONG_REF=Toxicol. Appl. Pharmacol.55(2): 393-402 Eaton,D.L., N.H. Stacey, K.L. Wong, and C.D. Klaassen Dose-Response Effects of Various Metal Ions on Rat Liver Metallothionein, Glutathione, Heme Oxygenase, and Cytochrome P-450 1980; TITLE=Dose-Response Effects of Various Metal Ions on Rat Liver Metallothionein, Glutathione, Heme Oxygenase, and Cytochrome P-450; AUTHOR=Eaton,D.L., N.H. Stacey, K.L. Wong, and C.D. Klaassen; DOI=10.1016/0041-008x(80)90101-5; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=86834; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1980; ORIGINAL_YEAR=1980; TOXICOLOGICAL_EFFECT=Enzyme(s): Heme oxygenase; TOXICOLOGICAL_EFFECT_CATEGORY=enzyme activity; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600372_15610468:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=869b88e367c97698cb8cd45218b3f5a6
ToxValDB_ECOTOX NOEL =3.2 mg/kg bw/day Rat injection acute; 0.0069 days acute LONG_REF=In: D.D.Hemphill (Ed.), Trace Substances in Environmental Health, University of Missouri, Columbia, MO:272-279 Ohanian,E.V., G. Schaechtelin, F.C. Brown, and J. Iwai Acute Effects of Intra-Arterial Injections of Cadmium, Mercury and Zinc on Blood Pressure and Cardiovascular Reactivity in Dahl Rats 1977; TITLE=Acute Effects of Intra-Arterial Injections of Cadmium, Mercury and Zinc on Blood Pressure and Cardiovascular Reactivity in Dahl Rats; AUTHOR=Ohanian,E.V., G. Schaechtelin, F.C. Brown, and J. Iwai; QUALITY=Control type: Baseline control; EXTERNAL_SOURCE_ID=67944; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1977; ORIGINAL_YEAR=1977; TOXICOLOGICAL_EFFECT=Physiology: Cardiac output; TOXICOLOGICAL_EFFECT_CATEGORY=clinical signs; STUDY_GROUP=ECOTOX_dup_EPA ORD_15600444_15602610_15604362:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=3cce73a793ec7b7febf66fccdd278fca
ToxValDB_ECOTOX NOEL =0.00138 mol/kg bw Mouse oral short-term; 21 days short-term LONG_REF=Arch. Environ. Health57(2): 98-102 Afonne,O.J., O.E. Orisakwe, E. Obi, C.E. Dioka, and G.I. Ndubuka Nephrotoxic Actions of Low-Dose Mercury in Mice: Protection by Zinc 2002; TITLE=Nephrotoxic Actions of Low-Dose Mercury in Mice: Protection by Zinc; AUTHOR=Afonne,O.J., O.E. Orisakwe, E. Obi, C.E. Dioka, and G.I. Ndubuka; DOI=10.1080/00039890209602923; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=100805; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2002; ORIGINAL_YEAR=2002; TOXICOLOGICAL_EFFECT=Growth: Weight; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX:15600944:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c1b689fee6609bd22bbb6bd2d4c7a1bf
ToxValDB_ECOTOX NOEL =59.1 umol/kg bw Mouse injection acute; 0.5 days acute LONG_REF=Reprod. Toxicol.22(4): 636-646 Kultima,K., E.L. Fernandez, B. Scholz, A.L. Gustafson, L. Dencker, and M. Stigson Cadmium-Induced Gene Expression Changes in the Mouse Embryo, and the Influence of Pretreatment with Zinc 2006; TITLE=Cadmium-Induced Gene Expression Changes in the Mouse Embryo, and the Influence of Pretreatment with Zinc; AUTHOR=Kultima,K., E.L. Fernandez, B. Scholz, A.L. Gustafson, L. Dencker, and M. Stigson; DOI=10.1016/j.reprotox.2006.05.007; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=101824; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2006; ORIGINAL_YEAR=2006; TOXICOLOGICAL_EFFECT=Genetics: Gene expression; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15604944:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=ec48e9fc4aa6318e6eb01d35283e72ca
ToxValDB_ECOTOX NOEL =15 umol/kg bw Mouse oral short-term; 3 days short-term LONG_REF=Food Chem. Toxicol.39(6): 571-577 Tandon,S.K., S. Singh, S. Prasad, and N. Mathur Hepatic and Renal Metallothionein Induction by an Oral Equimolar Dose of Zinc, Cadmium or Mercury in Mice 2001; TITLE=Hepatic and Renal Metallothionein Induction by an Oral Equimolar Dose of Zinc, Cadmium or Mercury in Mice; AUTHOR=Tandon,S.K., S. Singh, S. Prasad, and N. Mathur; DOI=10.1016/s0278-6915(00)00167-8; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=84303; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=2001; ORIGINAL_YEAR=2001; TOXICOLOGICAL_EFFECT=Accumulation: Residue|Biochemistry: Copper (Cu) content|Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15606140_15606141:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=2a0249530bca24c71219e968303694fa
ToxValDB_ECOTOX NOEL =2.5 % Rat dermal short-term; 3 days short-term LONG_REF=Bull. Environ. Contam. Toxicol.46(2): 249-254 Wormser,U., and S. BenZakine Increased Levels of Hepatic and Renal Metallothionein in the Rat and Guinea Pig After Percutaneous Application of Zinc Chloride 1991; TITLE=Increased Levels of Hepatic and Renal Metallothionein in the Rat and Guinea Pig After Percutaneous Application of Zinc Chloride; AUTHOR=Wormser,U., and S. BenZakine; DOI=10.1007/BF01691945; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85849; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Biochemistry: Metallothionein; TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX_dup_EPA ORD_15594913_15607194_15607195:unknown:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=059f9473d9310659a881216374be95ed
ToxValDB_ECOTOX NOEL =1 mM Mouse oral short-term; 2 days short-term LONG_REF=Chem. Senses12(2): 295-305 Kasahara,T., K. Iwasaki, and M. Sato Ingestive Responses to Some Heavy Metal Salts in Mice and Inhibition of Taste Nerve Responses by Metals 1987; TITLE=Ingestive Responses to Some Heavy Metal Salts in Mice and Inhibition of Taste Nerve Responses by Metals; AUTHOR=Kasahara,T., K. Iwasaki, and M. Sato; DOI=10.1093/chemse/12.2.295; QUALITY=Control type: Concurrent control; EXTERNAL_SOURCE_ID=66866; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1987; ORIGINAL_YEAR=1987; TOXICOLOGICAL_EFFECT=Feeding behavior: Water consumption; TOXICOLOGICAL_EFFECT_CATEGORY=food and/or water consumption; STUDY_GROUP=ECOTOX:15608113:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=bb4030c7461678e9aad39bbe4584c1e3
ToxValDB_ECOTOX NOEL =37.5 mg/kg bw/day Rat injection subchronic; 33 days subchronic LONG_REF=In: P.Collery, P.Bratter, V.Negretti de Bratter, L.Khassanova and J.C.Etienne (Eds.), Metal Ions in Biology and Medicine, Lisboa, Portugal5:722-725 Wadkins,T., J. Benz, and W. Briner Excessive Zinc Administration During Neural Tube Formation Effects Neuromuscular Development of the Rat 1998; TITLE=Excessive Zinc Administration During Neural Tube Formation Effects Neuromuscular Development of the Rat; AUTHOR=Wadkins,T., J. Benz, and W. Briner; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=79271; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1998; ORIGINAL_YEAR=1998; TOXICOLOGICAL_EFFECT=Growth: Weight gain; TOXICOLOGICAL_EFFECT_CATEGORY=body weight; STUDY_GROUP=ECOTOX_dup_EPA ORD_15611217_15611456:F:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=c8b9de71192bfaeb813463c24b1a52d8
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =1 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635777:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8075005d55bcf9ca185cf121067c857a
ToxValDB_HPVIS 6 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_HPVIS LOAEL =5910 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic LONG_REF=Maita, K., M. Hirano, K. Mitsumori, K. Takahashi, and Y. Shirasu. 1981. Subacute toxicity studies with zinc sulfate in mice and rats. J. Pesticide Sci., 6: 327-336.Original posting date(s) of the category on the in the HPV Challenge web site: January 23, 2003. Posting date(s) of revised documents from the HPV Challenge web site from which data have been entered into the HPVIS: Feb. 8, 2005. These documents were received by EPA on Jan. 06, 2004. Posting date(s) of final documents from the HPV Challenge web site from which data have been entered into the HPVIS: Jan. 1, 2007. These documents were received by EPA on Dec. 12, 2006; QUALITY=2; EXTERNAL_SOURCE_ID=60336; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639043_15639323:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_b14e4d95aa4ce5d02a8e77115ab7d717
ToxValDB_HPVIS LOAEL =12 mg/kg bw/day Rat oral short-term; 4 weeks short-term LONG_REF=Zaporowska, H. and W. Wasilewski. 1992. Combined effect of vanadium and zinc on certain selected haematological indices in rats. Comp. Biochem. Physiol., 103C: 143-147.Original posting date(s) of the category on the in the HPV Challenge web site: January 23, 2003. Posting date(s) of revised documents from the HPV Challenge web site from which data have been entered into the HPVIS: Feb. 8, 2005. These documents were received by EPA on Jan. 06, 2004. Posting date(s) of final documents from the HPV Challenge web site from which data have been entered into the HPVIS: Jan. 1, 2007. These documents were received by EPA on Dec. 12, 2006; QUALITY=2; EXTERNAL_SOURCE_ID=63205; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1992; ORIGINAL_YEAR=1992; STUDY_GROUP=HPVIS:15639372:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bd7cb7b3be88c49fb618d60e4863e31c
ToxValDB_HPVIS LOAEL =2880 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=Maita, K., M. Hirano, K. Mitsumori, K. Takahashi, and Y. Shirasu. 1981. Subacute toxicity studies with zinc sulfate in mice and rats. J. Pesticide Sci., 6: 327-336.Original posting date(s) of the category on the in the HPV Challenge web site: January 23, 2003. Posting date(s) of revised documents from the HPV Challenge web site from which data have been entered into the HPVIS: Feb. 8, 2005. These documents were received by EPA on Jan. 06, 2004. Posting date(s) of final documents from the HPV Challenge web site from which data have been entered into the HPVIS: Jan. 1, 2007. These documents were received by EPA on Dec. 12, 2006; QUALITY=2; EXTERNAL_SOURCE_ID=63997; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639139_15639469:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_76227e49b18689739f833deb8fb52e00
ToxValDB_HPVIS NOAEL =288 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=Maita, K., M. Hirano, K. Mitsumori, K. Takahashi, and Y. Shirasu. 1981. Subacute toxicity studies with zinc sulfate in mice and rats. J. Pesticide Sci., 6: 327-336.Original posting date(s) of the category on the in the HPV Challenge web site: January 23, 2003. Posting date(s) of revised documents from the HPV Challenge web site from which data have been entered into the HPVIS: Feb. 8, 2005. These documents were received by EPA on Jan. 06, 2004. Posting date(s) of final documents from the HPV Challenge web site from which data have been entered into the HPVIS: Jan. 1, 2007. These documents were received by EPA on Dec. 12, 2006; QUALITY=2; EXTERNAL_SOURCE_ID=61098; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639139_15639469:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_797d4c2e6a91fbe49168dfb0c1ca2e29
ToxValDB_HPVIS NOAEL =591 mg/kg bw/day Mouse oral subchronic; 13 weeks subchronic LONG_REF=Maita, K., M. Hirano, K. Mitsumori, K. Takahashi, and Y. Shirasu. 1981. Subacute toxicity studies with zinc sulfate in mice and rats. J. Pesticide Sci., 6: 327-336.Original posting date(s) of the category on the in the HPV Challenge web site: January 23, 2003. Posting date(s) of revised documents from the HPV Challenge web site from which data have been entered into the HPVIS: Feb. 8, 2005. These documents were received by EPA on Jan. 06, 2004. Posting date(s) of final documents from the HPV Challenge web site from which data have been entered into the HPVIS: Jan. 1, 2007. These documents were received by EPA on Dec. 12, 2006; QUALITY=2; EXTERNAL_SOURCE_ID=62682; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480596; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1981; ORIGINAL_YEAR=1981; STUDY_GROUP=HPVIS_dup_HPVIS Mammalian Repeat Dose_15639043_15639323:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7ab50c72a201cecd9024f2bd9cd96336
ToxValDB_HPVIS NOAEL =12.5 mg/kg bw/day Mouse injection short-term; 18 days developmental LONG_REF=Chang, C-H., D.E. Mann, and R.F. Gautieri. 1977. Teratogenicity of zinc chloride, 1,10-phenanthroline, and a zinc-1,10-phenanthroline complex in mice. J. Pharm. Sci., 66:1755-1758.Original posting date(s) of the category on the in the HPV Challenge web site: January 23, 2003. Posting date(s) of revised documents from the HPV Challenge web site from which data have been entered into the HPVIS: Feb. 8, 2005. These documents were received by EPA on Jan. 06, 2004. Posting date(s) of final documents from the HPV Challenge web site from which data have been entered into the HPVIS: Jan. 1, 2007. These documents were received by EPA on Dec. 12, 2006; QUALITY=2; EXTERNAL_SOURCE_ID=58227; EXTERNAL_SOURCE_ID_DESC=HPVIS ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/63861d6de4b04f6bb1480590; RECORD_SOURCE_LEVEL=Extraction document; YEAR=1977; ORIGINAL_YEAR=1977; STUDY_GROUP=HPVIS:15642387:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d3730f0736ebfb18317689147e5faaa8
ToxValDB_NIOSH_IDLH 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_NIOSH_IDLH NOEL =90 mg/m3 Rat inhalation acute acute LONG_REF=Richards RJ, Atkins J, Marrs TC, Brown RFR, Masek L [1989]. The biological and pathological changes produced by the intratracheal instillation of certain compounds of zinc-hexachloroethane smoke. Toxicology 54(1):79-88.; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/68c9b369e4b02565fc7d6aa2; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.cdc.gov/niosh/idlh/; SUBSOURCE_URL=https://www.cdc.gov/niosh/idlh/7646857.html; YEAR=1994; ORIGINAL_YEAR=1994; TOXICOLOGICAL_EFFECT=rat intratracheal fibrosis; STUDY_GROUP=NIOSH IDLH:15953831:-:--; QC_CATEGORY=Manually extracted from unstructured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_2d7acc730e0f07829e745d66273bcf07
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 86Q357L16B UNII - - - chemical {"approval_status":null,"molecular_formula":"2Cl.Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"86Q357L16B"}
openFDA substances FDA UNII substance identifier 86Q357L16B UNII - - - chemical {"approval_status":null,"molecular_formula":"2Cl.Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"86Q357L16B"}
openFDA substances FDA UNII substance identifier 86Q357L16B UNII - - - chemical {"approval_status":null,"molecular_formula":"2Cl.Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"86Q357L16B"}
openFDA substances FDA UNII substance identifier 86Q357L16B UNII - - - chemical {"approval_status":null,"molecular_formula":"2Cl.Zn","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"86Q357L16B"}