NOAEL Studies Cosmetic Ingredient

ZINC HYDROXIDE NOAEL Studies

CAS: 20427-58-1

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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ToxValDB_ECHA_IUCLID 10 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =5 mg/m3 Rabbit inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/3/3?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15797274:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6ae02c2824ff8e5ddb67b161f3aa4f7d
ToxValDB_ECHA_IUCLID LEL =1 mg/m3 Guinea Pig inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/3/3?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15797829:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1d0f7f485e2f486f71643e64b70648cd
ToxValDB_ECHA_IUCLID LEL =2.5 mg/m3 Guinea Pig inhalation - acute QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059759e4b063812d6fa6de; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/3/3?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15798916:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_7edc21e8848fb89c7eddccb96014f162
ToxValDB_ECHA_IUCLID LOAEC =0.55 mg/m3 Rat inhalation short-term; 5 days short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/6/3?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15829442:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_c62a10f1deb104ef0e0454594c1a6556
ToxValDB_ECHA_IUCLID LOAEC =4.45 mg/m3 Rat inhalation subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/6/3?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829594_15829595:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ed98b73b4f29a2651b7eeb416bf2cd1d
ToxValDB_ECHA_IUCLID LOAEL =7.5 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaac3e4b0a7c65d1b75f6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/9/2?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=P0: clinical signs|P0: mortality|P0: body weight and weight gain|P0: organ weights and organ / body weight ratios|P0: gross pathology|P0: reproductive performance; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|clinical signs|gross pathology|mortality/survival|organ weight|reproduction; STUDY_GROUP=ECHA IUCLID:15857488:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28db48360f446a2ba35248ae0118108f
ToxValDB_ECHA_IUCLID NOAEC =1.96 mg/m3 Rat inhalation short-term; 10 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/6/3?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15827179:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_79059b02a16d8b5ed25b49bb3bd1691d
ToxValDB_ECHA_IUCLID NOAEC =0.47 mg/m3 Rat inhalation short-term; 28 days short-term QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/6/3?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15828436:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_4908a5bd8ae5508f5c724b4cc6e533ed
ToxValDB_ECHA_IUCLID NOAEC =1.48 mg/m3 Rat inhalation subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/6/3?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; TOXICOLOGICAL_EFFECT=lungs; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829594_15829595:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b1f950d41c54f4a302e28525791c37b
ToxValDB_ECHA_IUCLID NOAEL =15 mg/kg bw/day Rat oral - reproduction developmental QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaac3e4b0a7c65d1b75f6; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/10329/7/9/2?documentUUID=9335e422-4b04-439e-b32c-4a913c2da116; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=ECHA IUCLID:15859410:M/F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8f553f6f115470bda45136593c3ea80b
openFDA substances 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier OXK3V8KJ7L UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn.2HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OXK3V8KJ7L"}
openFDA substances FDA UNII substance identifier OXK3V8KJ7L UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn.2HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OXK3V8KJ7L"}
openFDA substances FDA UNII substance identifier OXK3V8KJ7L UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn.2HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OXK3V8KJ7L"}
openFDA substances FDA UNII substance identifier OXK3V8KJ7L UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn.2HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OXK3V8KJ7L"}
openFDA substances FDA UNII substance identifier OXK3V8KJ7L UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn.2HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OXK3V8KJ7L"}
openFDA substances FDA UNII substance identifier OXK3V8KJ7L UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn.2HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OXK3V8KJ7L"}
openFDA substances FDA UNII substance identifier OXK3V8KJ7L UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn.2HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OXK3V8KJ7L"}
openFDA substances FDA UNII substance identifier OXK3V8KJ7L UNII - - - chemical {"approval_status":null,"molecular_formula":"Zn.2HO","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"OXK3V8KJ7L"}