NOAEL Studies
Active Ingredient
Zinc Pyrithione NOAEL Studies
INCI: ZINC PYRITHIONE
CAS: 13463-41-7
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS DB 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS DB | LOAEL | 1 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; study report |
| COSMOS DB | LOAEL | 1.39999997616 | mg/kg bw/day | rat | oral | 2 year | Chronic | REACH; study report |
| COSMOS DB | LOAEL | 1.5 | mg/kg bw/day | rat | oral | 2 year | Chronic | REACH; study report |
| COSMOS DB | LOAEL | 22 | mg/kg bw/day | primate | oral | 28 day | Subchronic | REACH; study report |
| COSMOS DB | NOAEL | 0.20000000298 | mg/kg bw/day | rat | oral | 90 day | Subchronic | REACH; study report |
| COSMOS DB | NOAEL | 0.5 | mg/kg bw/day | rat | oral | 2 year | Chronic | REACH; study report |
| COSMOS DB | NOAEL | 11 | mg/kg bw/day | primate | oral | 28 day | Subchronic | REACH; study report |
NTP ICE acute dermal 3 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute dermal | EPA classification | 3 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1752; Record_ID=acute_dermal_11; Data_Type=In Vivo; Formulation_ID=MIX11; Formulation_Name=Acticide SR 8213 C; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID7026314; Assay=Rat Acute Dermal Toxicity; Endpoint=EPA classification; Response=3.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE acute dermal | GHS classification | 5 | unitless | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1754; Record_ID=acute_dermal_11; Data_Type=In Vivo; Formulation_ID=MIX11; Formulation_Name=Acticide SR 8213 C; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID7026314; Assay=Rat Acute Dermal Toxicity; Endpoint=GHS classification; Response=5.0; Response_Unit=Unitless; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE acute dermal | LD50 | >2000 | mg/kg | Rat | Dermal | - | In Vivo; Rat Acute Dermal Toxicity | sheet=Data; excel_row=1751; Record_ID=acute_dermal_11; Data_Type=In Vivo; Formulation_ID=MIX11; Formulation_Name=Acticide SR 8213 C; Percent_Active_Ingredient=5.0; Mixture=Mixture; DTXSID=DTXSID7026314; Assay=Rat Acute Dermal Toxicity; Endpoint=LD50; Response_Modifier=>; Response=2000.0; Response_Unit=mg/kg; Species=Rat; Route=Dermal; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
NTP ICE acute inhalation 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute inhalation | EPA Classification | 4 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3991; Record_ID=acute_inhalation_417; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX611; Formulation_Name=Trilux 44 - White; Percent_Active_Ingredient=4.12; Mixture=Mixture; DTXSID=DTXSID7026314; Assay=Rat Acute Inhalation Toxicity; Endpoint=EPA Classification; Response=4; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE acute inhalation | GHS Classification | 5 | unitless | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3989; Record_ID=acute_inhalation_417; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX611; Formulation_Name=Trilux 44 - White; Percent_Active_Ingredient=4.12; Mixture=Mixture; DTXSID=DTXSID7026314; Assay=Rat Acute Inhalation Toxicity; Endpoint=GHS Classification; Response=5; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE acute inhalation | LC50 | 0.14 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3992; Record_ID=acute_inhalation_2812; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7026314; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.14; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE acute inhalation | LC50 | 0.84 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3988; Record_ID=acute_inhalation_1680; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7026314; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=0.84; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/3/3/?documentUUID=831c8bad-7c57-408a-b280-e48301764ab7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE acute inhalation | LC50 | 1.03 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3987; Record_ID=acute_inhalation_1683; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7026314; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.03; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/3/3/?documentUUID=831c8bad-7c57-408a-b280-e48301764ab7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE acute inhalation | LC50 | 1.34 | mg/L | - | Inhalation | Duration=4 hr | In Vivo; AcuteInhalNICEATM; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3990; Record_ID=acute_inhalation_1676; Data_Type=In Vivo; Internal_Data_Source=AcuteInhalNICEATM; Mixture=Chemical; DTXSID=DTXSID7026314; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response=1.34; Response_Unit=mg/L; Reference=REACH; URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/3/3/?documentUUID=831c8bad-7c57-408a-b280-e48301764ab7; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE acute inhalation | LC50 | >5.15 | mg/L | - | Inhalation | - | In Vivo; AcuteInhal6pack; Rat Acute Inhalation Toxicity | sheet=Data; excel_row=3986; Record_ID=acute_inhalation_417; Data_Type=In Vivo; Internal_Data_Source=AcuteInhal6pack; Formulation_ID=MIX611; Formulation_Name=Trilux 44 - White; Percent_Active_Ingredient=4.12; Mixture=Mixture; DTXSID=DTXSID7026314; Assay=Rat Acute Inhalation Toxicity; Endpoint=LC50; Response_Modifier=>; Response=5.15; Response_Unit=mg/L; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
NTP ICE acute oral 6 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13257; row=11997; data_type=In Vivo; mixture=Mixture; formulation_id=MIX711; formulation_name=Shelter Island Plus - White; chemical_name=Pyrithione zinc; preferred_name=Zinc pyrithione; percent_active_ingredient=4.0; dtxsid=DTXSID7026314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7026314; source_file=acute_oral.xlsx |
| NTP ICE acute oral | EPA classification | =3 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12197; row=11999; data_type=In Vivo; mixture=Mixture; formulation_id=MIX11; formulation_name=Acticide SR 8213 C; chemical_name=Pyrithione zinc; preferred_name=Zinc pyrithione; percent_active_ingredient=5.0; dtxsid=DTXSID7026314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7026314; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12197; row=12001; data_type=In Vivo; mixture=Mixture; formulation_id=MIX11; formulation_name=Acticide SR 8213 C; chemical_name=Pyrithione zinc; preferred_name=Zinc pyrithione; percent_active_ingredient=5.0; dtxsid=DTXSID7026314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7026314; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =4 | Unitless | Rat | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13257; row=12005; data_type=In Vivo; mixture=Mixture; formulation_id=MIX711; formulation_name=Shelter Island Plus - White; chemical_name=Pyrithione zinc; preferred_name=Zinc pyrithione; percent_active_ingredient=4.0; dtxsid=DTXSID7026314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7026314; source_file=acute_oral.xlsx |
| NTP ICE acute oral | GHS classification | =5 | Unitless | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_12975; row=12002; data_type=In Vivo; mixture=Mixture; formulation_id=MIX449; formulation_name=Shelter Island Plus; chemical_name=Pyrithione zinc; preferred_name=Zinc pyrithione; percent_active_ingredient=4.0; dtxsid=DTXSID7026314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7026314; source_file=acute_oral.xlsx |
| NTP ICE acute oral | LD50 | >2000 | mg/kg bw | Rat (Female) | oral | acute | Rat Acute Oral Toxicity | Studies submitted to EPA in support of pesticide registration applications (undated); record_id=acute_oral_13058; row=11996; data_type=In Vivo; mixture=Mixture; formulation_id=MIX611; formulation_name=Trilux 44 - White; chemical_name=Pyrithione zinc; preferred_name=Zinc pyrithione; percent_active_ingredient=4.12; dtxsid=DTXSID7026314; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; url_cebs=https://doi.org/10.22427/NTP-DATA-DTXSID7026314; source_file=acute_oral.xlsx |
NTP ICE dart 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE dart | LOEL | 1.5 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Reproductive performance | sheet=Data; excel_row=109476; Record_ID=dart_17370; Data_Type=In Vivo; DTXSID=DTXSID7026314; Assay=DART, Reproductive performance; Endpoint=LOEL; Response=1.5; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0035150;CUI;Reproduction|UMLS;C4086749;CUI;Post-implantation Loss Percent; Reference=ToxRefDB v2 , ID = 1753; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE dart | LOEL | 1.5 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=109477; Record_ID=dart_17375; Data_Type=In Vivo; DTXSID=DTXSID7026314; Assay=DART, In life observation; Endpoint=LOEL; Response=1.5; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C2983605;CUI;Food Consumption|UMLS;C3540840;CUI;Sign or Symptom|UMLS;C2983605;CUI;Food Consumption; Reference=ToxRefDB v2 , ID = 1753; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE dart | LOEL | 1.5 | mg/kg bw/day | Rabbit | Oral | - | In Vivo; DART, Offspring survival early | sheet=Data; excel_row=109478; Record_ID=dart_17377; Data_Type=In Vivo; DTXSID=DTXSID7026314; Assay=DART, Offspring survival early; Endpoint=LOEL; Response=1.5; Response_Unit=mg/kg/day; Species=Rabbit; Strain=New Zealand White; Sex=Male/Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0015954;CUI;Fetal Viability|UMLS;C4086644;CUI;Number of Live Fetuses; Reference=ToxRefDB v2 , ID = 1753; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE dart | LOEL | 3 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, In life observation | sheet=Data; excel_row=109479; Record_ID=dart_17566; Data_Type=In Vivo; DTXSID=DTXSID7026314; Assay=DART, In life observation; Endpoint=LOEL; Response=3; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Female; Life_Stage=Adult; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C3540840;CUI;Sign or Symptom|UMLS;C0013132;CUI;Drooling; Reference=ToxRefDB v2 , ID = 1754; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE dart | LOEL | 3 | mg/kg bw/day | Rat | Oral | - | In Vivo; DART, Developmental malformation | sheet=Data; excel_row=109480; Record_ID=dart_17572; Data_Type=In Vivo; DTXSID=DTXSID7026314; Assay=DART, Developmental malformation; Endpoint=LOEL; Response=3; Response_Unit=mg/kg/day; Species=Rat; Strain=Sprague Dawley (CD); Sex=Male/Female; Life_Stage=Fetal; Route=Oral; Critical_Effect=Yes; Unified_Medical_Language_System=UMLS;C0000768;CUI;Congenital Abnormality|UMLS;C0265509;CUI;Congenital anomaly of skeletal bone|UMLS;C0699952;CUI;Fused; Reference=ToxRefDB v2 , ID = 1754; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
NTP ICE endocrine 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE endocrine | AC50 | 0.246652718 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=16372; RecordID=ARPathway2016_64; DatasetName=ARPathway2016; DTXSID=DTXSID7026314; Assay=AR Pathway Model, Agonist; Endpoint=AC50; Response=0.246652718; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE endocrine | AC50 | 2.04176096879569 | uM | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=16378; RecordID=ERPathway2016_101; DatasetName=ERPathway2016; DTXSID=DTXSID7026314; Assay=ER Pathway Model, Agonist; Endpoint=AC50; Response=2.04176096879569; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE endocrine | ACC | 0.190148851 | uM | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=16373; RecordID=ARPathway2016_64; DatasetName=ARPathway2016; DTXSID=DTXSID7026314; Assay=AR Pathway Model, Agonist; Endpoint=ACC; Response=0.190148851; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE endocrine | ACC | 1.85188882209664 | uM | - | - | - | ERPathway2016; ER Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=16379; RecordID=ERPathway2016_101; DatasetName=ERPathway2016; DTXSID=DTXSID7026314; Assay=ER Pathway Model, Agonist; Endpoint=ACC; Response=1.85188882209664; Response_Unit=uM; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE endocrine | Model Score | 0 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Agonist | sheet=Integrated_approaches; excel_row=16375; RecordID=ARPathway2016_64; DatasetName=ARPathway2016; DTXSID=DTXSID7026314; Assay=AR Pathway Model, Agonist; Endpoint=Model Score; Response=0; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE endocrine | Model Score | 0.237 | unitless | - | - | - | ERPathway2016; ER Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=16381; RecordID=ERPathway2016_101; DatasetName=ERPathway2016; DTXSID=DTXSID7026314; Assay=ER Pathway Model, Antagonist; Endpoint=Model Score; Response=0.237; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE endocrine | Model Score | 0.645 | unitless | - | - | - | ARPathway2016; AR Pathway Model, Antagonist | sheet=Integrated_approaches; excel_row=16374; RecordID=ARPathway2016_64; DatasetName=ARPathway2016; DTXSID=DTXSID7026314; Assay=AR Pathway Model, Antagonist; Endpoint=Model Score; Response=0.645; Response_Unit=Unitless; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
NTP ICE eye irritation 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE eye irritation | EPA Classification | 1 | unitless | Rabbit | Ocular | - | In Vivo; Draize Eye Irritation/Corrosion Test | sheet=Data; excel_row=2071; Record_ID=eye_irritation_1018; Data_Type=In Vivo; Formulation_ID=EyeIrritation6pack_PID871; Formulation_Name=Shelter Island Plus; Percent_Active_Ingredient=4.0; Mixture=Mixture; DTXSID=DTXSID7026314; Assay=Draize Eye Irritation/Corrosion Test; Endpoint=EPA Classification; Response=1; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA data; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
NTP ICE skin irritation 2 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin irritation | EPA classification | 3 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1372; Record_ID=skin_irritation_invivo_523; Data_Type=In Vivo; Formulation_ID=MIX11; Formulation_Name=Acticide SR 8213 C; Percent_Active_Ingredient=5; Mixture=Mixture; DTXSID=DTXSID7026314; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=3; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE skin irritation | EPA classification | 4 | unitless | Rabbit | Dermal | - | In Vivo; Draize Skin Irritation/Corrosion Test | sheet=Data_invivo; excel_row=1373; Record_ID=skin_irritation_invivo_614; Data_Type=In Vivo; Formulation_ID=MIX449; Formulation_Name=Shelter Island Plus; Percent_Active_Ingredient=4; Mixture=Mixture; DTXSID=DTXSID7026314; Assay=Draize Skin Irritation/Corrosion Test; Endpoint=EPA classification; Response=4; Response_Unit=Unitless; Species=Rabbit; Reference=FIFRA (undated); URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
NTP ICE skin sensitization 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP ICE skin sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=4833; Record_ID=skin_sensitization_invivo_1159; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7026314; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE skin sensitization | Induction dose per skin area | 852.5 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=4831; Record_ID=skin_sensitization_invivo_1159; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7026314; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=852.5; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE skin sensitization | Induction dose per skin area | 2093 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=4847; Record_ID=skin_sensitization_invivo_1163; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7026314; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=2093; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
| NTP ICE skin sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=4821; Record_ID=skin_sensitization_invivo_1155; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=3.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID7026314; Assay=Human Repeat Insult Patch Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Marzulli and Maibach 1973; Not available; Not available; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID7026314; URL_CEBS=https://doi.org/10.22427/NTP-DATA-DTXSID7026314 |
SCCNFP Opinion 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCNFP Opinion | NOAEL | =0.5 | mg/kg/day | rat | oral | 14 days | NOAEL study | p.8 |
| SCCNFP Opinion | NOAEL | =0.6 | mg/kg/d | rat | oral | chronic | NOAEL study | p.11 |
| SCCNFP Opinion | NOAEL | =100 | mg/kg/d | human | oral | chronic | carcinogenicity | p.31 |
| SCCNFP Opinion | NOAEL | =400 | mg/kg/day | rat | oral | - | reproductive toxicity | p.31 |
SCCS Opinion 25 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| SCCS Opinion | NOAEL | =0.5 | mg/kg/day | rat | oral | 14 days | NOAEL study | p.32 |
| SCCS Opinion | NOAEL | =0.5 | mg/kg/d | - | oral | chronic | NOAEL study | p.40 |
| SCCS Opinion | NOAEL | =0.5 | mg/kg bw/d | rat | - | chronic | carcinogenicity | p.41 |
| SCCS Opinion | NOAEL | =0.75 | mg/kg/d | rabbit | oral | developmental | developmental toxicity | p.56 |
| SCCS Opinion | NOAEL | =1.5 | mg/kg/d | rat | - | - | reproductive toxicity | p.51 |
| SCCS Opinion | NOAEL | =1.5 | mg/kg bw/d | rat | oral | - | reproductive toxicity | p.52 |
| SCCS Opinion | NOAEL | =2 | mg/kg/d | - | oral | 28 days | NOAEL study | p.33 |
| SCCS Opinion | NOAEL | =2 | % | human | - | - | irritation | p.80 |
| SCCS Opinion | NOAEL | =3.5 | mg/kg/d | rat | oral | - | reproductive toxicity | p.51 |
| SCCS Opinion | NOAEL | =5 | mg/kg/d | - | oral | chronic | repeated dose toxicity | p.43 |
| SCCS Opinion | NOAEL | =5 | mg/kg bw/d | rat | dermal | 28-day | NOAEL study | p.44 |
| SCCS Opinion | NOAEL | =7.5 | mg/kg/d | rat | dermal | 8-week | reproductive toxicity | p.50 |
| SCCS Opinion | NOAEL | =11 | mg/kg bw/d | rat | oral | 90-day | NOAEL study | p.34 |
| SCCS Opinion | NOAEL | =14 | - | rat | oral | - | NOAEL study | p.73 |
| SCCS Opinion | NOAEL | =15 | mg/kg bw/d | rat | - | developmental | reproductive toxicity | p.57 |
| SCCS Opinion | NOAEL | =25 | mg/kg bw/d | - | dermal | - | NOAEL study | Ref.: D1 In vitro studies Knox et al, p.76 |
| SCCS Opinion | NOAEL | =30 | mg/kg bw /d | rat | - | developmental | reproductive toxicity | p.57 |
| SCCS Opinion | NOAEL | =50 | ppm | rat | - | Chronic | NOAEL study | Ref.: E14 ECHA's website (http://echa, p.40 |
| SCCS Opinion | NOAEL | =88 | % | rat | oral | chronic | carcinogenicity | p.80 |
| SCCS Opinion | NOAEL | =100 | mg/kg bw/d | mouse | oral | 10 day | NOAEL study | p.36 |
| SCCS Opinion | NOAEL | =100 | mg/kg/d | rat | oral | subchronic | repeated dose toxicity | p.37 |
| SCCS Opinion | NOAEL | =100 | % | rat | oral | chronic | carcinogenicity | p.80 |
| SCCS Opinion | NOAEL | =500 | - | - | oral | chronic | carcinogenicity | p.43 |
| SCCS Opinion | NOAEL | =1995 | - | rat | oral | - | NOAEL study | p.73 |
| SCCS Opinion | NOAEL | =2000 | mg/kg | - | oral | sub-chronic | repeated dose toxicity | p.81 |
EPA ToxRefDB v3 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| EPA ToxRefDB v3 | LEL | =1.5 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=1753; toxval_study_source_id=studyid1753_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-postimplantation loss-postimplantation loss|reproductive performance-pregnancy-pregnancy|reproductive performance-aborted-aborted|reproductive performance-resorptions-resorptions; dose_level=2; study_year=1993; study_citation=Schardein, J. (1993) Developmental Toxicity Study In New Zealand White Rabbits With Zinc Omadine: Lab Project Number: 397-056: Irdc. Unpublished Study Prepared By International Research And Development Corp. 161 P.; dsstox_substance_id=DTXSID7026314; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =3 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=1753; toxval_study_source_id=studyid1753_Fetal_Fetal_MF_developmental; toxval_effect_list=developmental malformation-general-[other]; dose_level=3; study_year=1993; study_citation=Schardein, J. (1993) Developmental Toxicity Study In New Zealand White Rabbits With Zinc Omadine: Lab Project Number: 397-056: Irdc. Unpublished Study Prepared By International Research And Development Corp. 161 P.; dsstox_substance_id=DTXSID7026314; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =15 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=1754; toxval_study_source_id=studyid1754_Adult Pregnancy_Fetal_MF_reproductive; toxval_effect_list=offspring survival early-live fetuses-live fetuses; dose_level=3; study_year=1993; study_citation=James L Schardein. 1993. Developmental Toxicity Study in Rats with Zinc Omadine (pyrithione) Study #: 397-055: International Research and Development Corporation, Mattawan, MI: May 27, 1993; dsstox_substance_id=DTXSID7026314; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | LEL | =1000 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | dermal | 0 week to 13 week | SUB | study_id=6066; toxval_study_source_id=studyid6066_Adult_F0_F_systemic; toxval_effect_list=in life observation-food consumption-food consumption|in life observation-food consumption-food efficiency|in life observation-body weight-body weight|in life observation-clinical signs-skin discoloration; dose_level=3; study_year=1993; study_citation=Ulrich, CE. 1993. 90-day subchronic dermal toxicity study on zinc omadine in rats. International Research and Development Corp., Mattawan, MI. Study no. 397-057. MRID 42827902.; dsstox_substance_id=DTXSID7026314; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =0.5 | mg/kg bw/day | rabbit (new zealand white; New Zealand White) | oral | 6 GD to 18 GD | DEV | study_id=1753; toxval_study_source_id=studyid1753_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-pregnancy-pregnancy|reproductive performance-postimplantation loss-postimplantation loss|reproductive performance-resorptions-resorptions|reproductive performance-aborted-aborted; dose_level=1; study_year=1993; study_citation=Schardein, J. (1993) Developmental Toxicity Study In New Zealand White Rabbits With Zinc Omadine: Lab Project Number: 397-056: Irdc. Unpublished Study Prepared By International Research And Development Corp. 161 P.; dsstox_substance_id=DTXSID7026314; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =0.75 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | oral | 6 GD to 15 GD | DEV | study_id=1754; toxval_study_source_id=studyid1754_Adult Pregnancy_F0_F_reproductive; toxval_effect_list=reproductive performance-resorptions-resorptions|reproductive performance-postimplantation loss-postimplantation loss; dose_level=1; study_year=1993; study_citation=James L Schardein. 1993. Developmental Toxicity Study in Rats with Zinc Omadine (pyrithione) Study #: 397-055: International Research and Development Corporation, Mattawan, MI: May 27, 1993; dsstox_substance_id=DTXSID7026314; admin_method=Gavage/Intubation; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
| EPA ToxRefDB v3 | NEL | =100 | mg/kg bw/day | rat (sprague dawley; Sprague Dawley (CD)) | dermal | 0 week to 13 week | SUB | study_id=6066; toxval_study_source_id=studyid6066_Adult_F0_F_systemic; toxval_effect_list=in life observation-clinical signs-skin discoloration|in life observation-food consumption-food consumption|in life observation-food consumption-food efficiency|in life observation-body weight-body weight; dose_level=2; study_year=1993; study_citation=Ulrich, CE. 1993. 90-day subchronic dermal toxicity study on zinc omadine in rats. International Research and Development Corp., Mattawan, MI. Study no. 397-057. MRID 42827902.; dsstox_substance_id=DTXSID7026314; admin_method=Topical; cas_source=toxval_ToxRefDB.xlsx:DTXSID; blob_url=https://clowder.edap-cluster.com/files/688cbadae4b02565bc3f8c07/blob; blob_sha256=69dd2da06ffc6a98a1bed684c347d8b2f31e6d35d607d4f2f83ebb6845a708d5 |
ECHA 24 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ECHA | LOAEL | =1 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead3fe4b0a7c65d1c349a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843458_15850950:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_7f554975f3a4d904c22fecb8d8734119 |
| ECHA | LOAEL | =1.4 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b6652; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/9/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15855934:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_839c881c1ffbf08fa8f20acd195015eb |
| ECHA | LOAEL | =1.5 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b6658; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/9/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15860702:F:F1-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1ff63d31d6e61eec7976a2e6ac30ff6f |
| ECHA | LOAEL | =1.95 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9e4e4b0a7c65d1b3412; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/8?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816136_15820336:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_03dd225cec1f27157b8138c12a176f9b |
| ECHA | LOAEL | =2.5 | mg/m3 | Rat | inhalation | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21815f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/10/1?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825563_15825564:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_855a896e517a40ab2618588b1087b8a4 |
| ECHA | LOAEL | =2.8 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b6652; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/9/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15855043:M:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_124cb9bbed69f4f7a796643e9664cb24 |
| ECHA | LOAEL | =3 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabdde4b0a7c65d1bc2d1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/9/3?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15824216:-:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1026735f36b9a1ad9e10fc64c1feb251 |
| ECHA | LOAEL | =3.5 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa8be4b0a7c65d1b6658; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/9/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15855465:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1706906e892fa6773567e576be7b00d4 |
| ECHA | LOAEL | =6 | mg/m3 | Rat | inhalation | short-term; 21 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/3?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829194_15829195:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d5266ae168817f11b4f63f579de03dfc |
| ECHA | LOAEL | >8 | mg/kg bw/day | Monkey | oral | chronic; 93 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca6be4b0a7c65d221d31; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15837800_15837801:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_909deb79cf5f60cde9bf133453f0d8a1 |
| ECHA | LOAEL | =22 | mg/kg bw/day | Monkey | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca76e4b0a7c65d221e13; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15848008_15849123:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fdc1be50cc8473ef4cd427edfd6da405 |
| ECHA | LOAEL | =75 | mg/kg bw/day | Rat | oral | - | repeat dose other | GUIDELINE=OECD Guideline 424 (Neurotoxicity Study in Rodents); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4ee8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/10/1?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825627_15826080:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5cf58c538fd9b713c72bbe5725a9d734 |
| ECHA | LOAEL | =1000 | mg/kg bw/day | Rat | dermal | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218163; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/10/1?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825681_15825682:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_417c9a70ce18075e4b314a19d17148fe |
| ECHA | NOAEL | =0.39 | mg/kg bw/day | Rat | oral | chronic; 94 days | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead3fe4b0a7c65d1c3498; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15839644_15850690:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8835ffb8b8468b0001d47532c8ba2a7f |
| ECHA | NOAEL | =0.5 | mg/m3 | Rat | inhalation | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d21815f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/10/1?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825563_15825564:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bf9a839d1cabc9dbf91a367f08536009 |
| ECHA | NOAEL | =0.78 | mg/kg bw/day | Rat | oral | - | chronic | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ea9e4e4b0a7c65d1b3412; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/8?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Carcinogenicity_15816136_15820336:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9b059da8be7d088a7f85b1b837a52c06 |
| ECHA | NOAEL | =2 | mg/m3 | Rat | inhalation | short-term; 21 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/3?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829194_15829195:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8ea9428859756016f515a3580738bdc5 |
| ECHA | NOAEL | =11 | mg/kg bw/day | Monkey | oral | short-term; 28 days | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7ca76e4b0a7c65d221e13; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15848008_15849123:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6d230709bdaf56d40f43a8cf3ab54080 |
| ECHA | NOAEL | =25 | mg/kg bw/day | Rat | oral | - | repeat dose other | GUIDELINE=OECD Guideline 424 (Neurotoxicity Study in Rodents); QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaa3ee4b0a7c65d1b4ee8; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/10/1?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825627_15826080:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_6ba2045eb1ddfc0548c5dbf18d9d6a50 |
| ECHA | NOAEL | =100 | mg/kg bw/day | Rat | dermal | - | repeat dose other | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218163; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/10/1?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Neurotoxicity_15825681_15825682:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_8dbf7d312d93e119469747305a7336c0 |
| ECHA | NOEL | =0.2 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669ead3fe4b0a7c65d1c349a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/2?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15843458_15850950:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_08a3543ea2b41013afec22c4c7305a5b |
| ECHA | NOEL | =5 | mg/kg bw/day | Mouse | dermal | chronic; 80 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e3be4b096bca8778e1f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/4?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826448_15826449:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_6e3a695a35c340a9c26cc28f349d60b5 |
| ECHA | NOEL | =11 | mg/kg bw/day | Monkey | oral | - | repeat dose other | GUIDELINE=other:; QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c85ae4b0a7c65d218167; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/10/1?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID:15825955:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0b1a3d4c28e519d6221c0abe3ce4d146 |
| ECHA | NOEL | =15 | mg/kg bw/day | Mouse | dermal | chronic; 80 weeks | chronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/67c61e3be4b096bca8778e1f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/14333/7/6/4?documentUUID=ba3559d3-0936-47ff-8796-f4017e5bc7a0; YEAR=1994; ORIGINAL_YEAR=1994; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Dermal_15826448_15826449:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_30469a82dfc7ce36a5e0c2b56b6b84e2 |
ToxValDB ECOTOX 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ECOTOX | NOEL | =20 | % w/v | Mouse | dermal | short-term; 5 days | short-term | LONG_REF=Food Chem. Toxicol.29(1): 57-64 Lansdown,A.B.G. Interspecies Variations in Response to Topical Application of Selected Zinc Compounds 1991; TITLE=Interspecies Variations in Response to Topical Application of Selected Zinc Compounds; AUTHOR=Lansdown,A.B.G.; DOI=10.1016/0278-6915(91)90063-d; QUALITY=Control type: Carrier or solvent control; EXTERNAL_SOURCE_ID=85721; EXTERNAL_SOURCE_ID_DESC=ECOTOX Reference Number; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6759bce8e4b0a7c65d37bc5f; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://cfpub.epa.gov/ecotox/; YEAR=1991; ORIGINAL_YEAR=1991; TOXICOLOGICAL_EFFECT=Genetics: Mitotic index (# mitoses/total cells); TOXICOLOGICAL_EFFECT_CATEGORY=other; STUDY_GROUP=ECOTOX:15600663:M:--; QC_CATEGORY=Data source QC'd by data provider prior to ECOTOX import; QC_STATUS=not determined; SOURCE_HASH=07041e6ba83b15c2339b252e34b7229d |
ToxValDB ToxRefDB 5 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB ToxRefDB | LEL | =1.5 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Schardein, J. (1993) Developmental Toxicity Study In New Zealand White Rabbits With Zinc Omadine: Lab Project Number: 397-056: Irdc. Unpublished Study Prepared By International Research And Development Corp. 161 P.; TITLE=Developmental Toxicity Study In New Zealand White Rabbits With Zinc Omadine: Lab Project Number: 397-056: Irdc; AUTHOR=Schardein, J; EXTERNAL_SOURCE_ID=1753; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-postimplantation loss-postimplantation loss|reproductive: reproductive performance-pregnancy-pregnancy|reproductive: reproductive performance-aborted-aborted|reproductive: reproductive performance-resorptions-resorptions; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15689545_15689546_15689547_15689548:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_fb86eee79f926467a60584d87a9ace0e |
| ToxValDB ToxRefDB | LEL | =3 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | developmental | LONG_REF=Schardein, J. (1993) Developmental Toxicity Study In New Zealand White Rabbits With Zinc Omadine: Lab Project Number: 397-056: Irdc. Unpublished Study Prepared By International Research And Development Corp. 161 P.; TITLE=Developmental Toxicity Study In New Zealand White Rabbits With Zinc Omadine: Lab Project Number: 397-056: Irdc; AUTHOR=Schardein, J; EXTERNAL_SOURCE_ID=1753; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=developmental: developmental malformation-general-[other]; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ToxRefDB_dup_-_15689557_15689558:M/F:fetusfetal; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_5b45dbced821041e46a8a0afc2735447 |
| ToxValDB ToxRefDB | LEL | =15 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | developmental | LONG_REF=James L Schardein. 1993. Developmental Toxicity Study in Rats with Zinc Omadine (pyrithione) Study #: 397-055: International Research and Development Corporation, Mattawan, MI: May 27, 1993; TITLE=Developmental Toxicity Study in Rats with Zinc Omadine (pyrithione); AUTHOR=James L Schardein; EXTERNAL_SOURCE_ID=1754; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: offspring survival early-live fetuses-live fetuses; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15689561_15689562:M/F:fetusadult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_66dd4fc5493a5945da30f1aa7d6e445f |
| ToxValDB ToxRefDB | NEL | =0.5 | mg/kg bw/day | Rabbit | oral | short-term (developmental); 13 days | reproduction developmental | LONG_REF=Schardein, J. (1993) Developmental Toxicity Study In New Zealand White Rabbits With Zinc Omadine: Lab Project Number: 397-056: Irdc. Unpublished Study Prepared By International Research And Development Corp. 161 P.; TITLE=Developmental Toxicity Study In New Zealand White Rabbits With Zinc Omadine: Lab Project Number: 397-056: Irdc; AUTHOR=Schardein, J; EXTERNAL_SOURCE_ID=1753; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-resorptions-resorptions|reproductive: reproductive performance-aborted-aborted|reproductive: reproductive performance-pregnancy-pregnancy|reproductive: reproductive performance-postimplantation loss-postimplantation loss; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15689545_15689546_15689547_15689548:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_06373a2d2350a91e545bc28d45e5e4ea |
| ToxValDB ToxRefDB | NEL | =0.75 | mg/kg bw/day | Rat | oral | short-term (developmental); 10 days | reproduction developmental | LONG_REF=James L Schardein. 1993. Developmental Toxicity Study in Rats with Zinc Omadine (pyrithione) Study #: 397-055: International Research and Development Corporation, Mattawan, MI: May 27, 1993; TITLE=Developmental Toxicity Study in Rats with Zinc Omadine (pyrithione); AUTHOR=James L Schardein; EXTERNAL_SOURCE_ID=1754; EXTERNAL_SOURCE_ID_DESC=ToxRefDB Study ID; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66bca4a3e4b0a7c65d2a792a; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://github.com/USEPA/CompTox-ToxRefDB; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=reproductive: reproductive performance-resorptions-resorptions|reproductive: reproductive performance-postimplantation loss-postimplantation loss; TOXICOLOGICAL_EFFECT_CATEGORY=reproduction; STUDY_GROUP=ToxRefDB_dup_-_15689559_15689560:F:F0adult-pregnancy; QC_CATEGORY=Data source QC'd by data provider prior to ToxRefDB import; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d39f1e543d19f4369b61fb72a5d44896 |
Regulatory source 33 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| Regulatory source | - | 0.5 | mg/kg/day | rat | oral | 14 days | - | p.8 |
| Regulatory source | - | 0.6 | mg/kg/d | rat | oral | chronic | - | p.11 |
| Regulatory source | carcinogenicity | 100 | mg/kg/d | human | oral | chronic | carcinogenicity | p.31 |
| Regulatory source | reproductive toxicity | 400 | mg/kg/day | rat | oral | - | reproductive toxicity | p.31 |
| Regulatory source | - | 0.5 | mg/kg/d | rat | oral | 90-day | - | p.34 |
| Regulatory source | - | 0.5 | mg/kg/d | - | oral | chronic | - | p.40 |
| Regulatory source | - | 2 | mg/kg/d | - | oral | 28 days | - | p.33 |
| Regulatory source | - | 5 | mg/kg bw/d | rat | dermal | 28-day | - | p.44 |
| Regulatory source | - | 11 | mg/kg bw/d | rat | oral | 90-day | - | p.34 |
| Regulatory source | - | 14 | - | rat | oral | - | - | p.73 |
| Regulatory source | - | 25 | mg/kg bw/d | - | dermal | - | - | p.76 |
| Regulatory source | - | 50 | ppm | rat | - | Chronic | - | p.40 |
| Regulatory source | - | 100 | mg/kg bw/d | mouse | oral | 10 day | - | p.36 |
| Regulatory source | - | 500 | - | rat | - | - | - | p.69 |
| Regulatory source | - | 500 | - | rat | oral | - | - | p.73 |
| Regulatory source | - | 1995 | - | rat | oral | - | - | p.73 |
| Regulatory source | carcinogenicity | 0.5 | mg/kg bw/d | rat | - | chronic | carcinogenicity | p.41 |
| Regulatory source | carcinogenicity | 0.5 | mg/kg/d | - | - | Chronic | carcinogenicity | p.42 |
| Regulatory source | carcinogenicity | 88 | % | rat | oral | chronic | carcinogenicity | p.80 |
| Regulatory source | carcinogenicity | 100 | % | rat | oral | chronic | carcinogenicity | p.80 |
| Regulatory source | carcinogenicity | 500 | - | - | oral | chronic | carcinogenicity | p.43 |
| Regulatory source | developmental toxicity | 0.5 | mg/kg bw/d | rat | dermal | developmental | developmental toxicity | p.56 |
| Regulatory source | developmental toxicity | 0.75 | mg/kg/d | rabbit | oral | developmental | developmental toxicity | p.56 |
| Regulatory source | irritation | 2 | % | human | - | - | irritation | p.80 |
| Regulatory source | repeated dose toxicity | 5 | mg/kg/d | - | oral | chronic | repeated dose toxicity | p.43 |
| Regulatory source | repeated dose toxicity | 100 | mg/kg/d | rat | oral | subchronic | repeated dose toxicity | p.37 |
| Regulatory source | repeated dose toxicity | 2000 | mg/kg | - | oral | sub-chronic | repeated dose toxicity | p.81 |
| Regulatory source | reproductive toxicity | 1.5 | mg/kg/d | rat | - | - | reproductive toxicity | p.51 |
| Regulatory source | reproductive toxicity | 1.5 | mg/kg bw/d | rat | oral | - | reproductive toxicity | p.52 |
| Regulatory source | reproductive toxicity | 3.5 | mg/kg/d | rat | oral | - | reproductive toxicity | p.51 |
| Regulatory source | reproductive toxicity | 7.5 | mg/kg/d | rat | dermal | 8-week | reproductive toxicity | p.50 |
| Regulatory source | reproductive toxicity | 15 | mg/kg bw/d | rat | - | developmental | reproductive toxicity | p.57 |
| Regulatory source | reproductive toxicity | 30 | mg/kg bw /d | rat | - | developmental | reproductive toxicity | p.57 |
openFDA substances 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | R953O2RHZ5 | UNII | - | - | - | chemical | - |