OralParenteralDosed ingredientTherapeutic flag
Cosmetic cross-reference
Tranexamic Acid
CAS 1197-18-8
Tranexamic Acid (CAS 1197-18-8) is a Phase 4 pharmaceutical compound with 1 bioactivity target and 1,992 adverse event associations.
SOURCE
NLM DailyMed
Label records
0
SOURCE
EMBL-EBI ChEMBL
Bioactivity
5
SOURCE
DrugCentral
Adverse signals
1,992
SOURCE
IUPHAR/BPS
PubMed IDs
1
SOURCE
EMBL-EBI ChEMBL
B25820EEF0F0
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Primary Name
Tranexamic Acid
CAS Number
1197-18-8
UNII
6T84R30KC1
InChIKey
GYDJEQRTZSCIOI-LJGSYFOKSA-N
ChEMBL ID
CHEMBL877
Molecule Type
Small molecule
Source Match
EMBL-EBI ChEMBL (INCHIKEY)
Synonyms and normalized names
Cyklokapron
dosed ingredientnatural productoralparenteraltherapeutic flag
SOURCE
EMBL-EBI ChEMBL
B25820EEF0F0
Clinical Development Phase
Highest clinical development phase rendered from the matched compound identifier rows.
Phase 4 (Approved)
Approved or marketed human pharmaceutical use is represented in the source phase field.
ChEMBL CHEMBL877 | Small molecule
SOURCE
Ingredients table / CosIng profile
same-CAS cross-reference
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
SOURCE
EMBL-EBI ChEMBL
5 bioactivity rows
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| - | AC50 | 13750 nM | 64 | - |
| - | IC50 | 15300.3275 nM | 7 | - |
| - | Kd | 10100 nM | 4 | - |
| - | EC50 | 19200 nM | 1 | - |
| Plasminogen Enzyme |
Kd | 5.96 | - | Homo sapiens |
SOURCE
DrugCentral
80 associations
Adverse Event Associations
DrugCentral / FAERS disproportionality signal rows matched to this compound.
| Reaction PT | Drug AE | LLR | MedDRA |
|---|---|---|---|
| Myoclonus | 92 | 156.534 | 10028622 |
| Wrong product administered | 68 | 149.823 | 10081579 |
| Generalised tonic-clonic seizure | 93 | 119.011 | 10018100 |
| Anaphylactic reaction | 125 | 115.306 | 10002198 |
| Haemorrhage | 135 | 113.464 | 10055798 |
| Febrile neutropenia | 197 | 103.603 | 10016288 |
| Seizure | 185 | 102.034 | 10039906 |
| Aplastic anaemia | 59 | 101.728 | 10002967 |
| Vasodilatation | 35 | 98.157 | 10047141 |
| Platelet count decreased | 178 | 97.339 | 10035528 |
| Cerebral infarction | 78 | 85.117 | 10008118 |
| Factor VIII inhibition | 19 | 81.898 | 10048619 |
| Pulmonary embolism | 153 | 81.152 | 10037377 |
| Status epilepticus | 58 | 79.482 | 10041962 |
| Melaena | 82 | 76.996 | 10027141 |
| Fatigue | 106 | 69.387 | 10016256 |
| Purpura | 48 | 68.528 | 10037549 |
| Haemoptysis | 75 | 66.717 | 10018964 |
| Hereditary angioedema | 34 | 64.584 | 10019860 |
| Vaginal haemorrhage | 49 | 61.816 | 10046910 |
| Product packaging confusion | 19 | 59.169 | 10074776 |
| Renal cortical necrosis | 14 | 58.532 | 10038422 |
| Post procedural hypotension | 11 | 58.273 | 10084013 |
| Heavy menstrual bleeding | 38 | 54.028 | 10085423 |
| Deep vein thrombosis | 104 | 51.076 | 10051055 |
| Haemarthrosis | 26 | 51.034 | 10018829 |
| Joint swelling | 13 | 49.815 | 10023232 |
| Product dose omission issue | 8 | 49.396 | 10084406 |
| Drug intolerance | 12 | 49.375 | 10061822 |
| Myoclonic epilepsy | 19 | 48.787 | 10054859 |
| Rash maculo-papular | 62 | 48.11 | 10037868 |
| Hepatic function abnormal | 72 | 47.248 | 10019670 |
| Pain | 86 | 46.297 | 10033371 |
| Arthropathy | 4 | 45.767 | 10003285 |
| Acute myocardial infarction | 72 | 45.741 | 10000891 |
| Epistaxis | 92 | 45.403 | 10015090 |
| Thrombocytopenia | 163 | 45.27 | 10043554 |
| Post procedural haemorrhage | 33 | 43.676 | 10051077 |
| Anaphylactic shock | 48 | 43.413 | 10002199 |
| Alopecia | 15 | 42.373 | 10001760 |
| Upper respiratory tract inflammation | 20 | 41.363 | 10049590 |
| Biliary sepsis | 15 | 40.027 | 10057847 |
| Cerebral haemorrhage | 60 | 39.858 | 10008111 |
| Rash erythematous | 60 | 39.416 | 10037855 |
| Systemic lupus erythematosus | 3 | 39.191 | 10042945 |
| Rheumatoid arthritis | 10 | 38.067 | 10039073 |
| Haemorrhagic diathesis | 22 | 37.067 | 10062713 |
| Neutropenic sepsis | 40 | 37.035 | 10049151 |
| Retinal artery occlusion | 17 | 35.092 | 10038827 |
| Haemoglobin increased | 21 | 34.757 | 10018888 |
Association rows are source-linked signal records, not incidence rates or clinical causality claims.
SOURCE
IUPHAR/BPS
1 interaction
IUPHAR Ligand-Target Data
Curated ligand-target interaction rows with action, affinity, and literature identifiers.
| Target | Action | Affinity | PubMed |
|---|---|---|---|
| plasminogen PLG |
Binding | 3.5999999046325684 pIC50 | 17666018 |
SOURCE
NLM RxNorm
5 name rows
Drug Names / RxNorm
Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.
| Name | RxCUI | Type | Source |
|---|---|---|---|
| TRANEXAMIC ACID | 10691 | SU | MTHSPL |
| Tranexamic Acid | 10691 | SU | MTHSPL |
| tranexamic acid | 10691 | SU | MTHSPL |
| tranexamic acid | 10691 | IN | RXNORM |
| Cyklokapron | 151568 | BN | RXNORM |
SOURCE
SIDER
80 side-effect rows
Side Effects
SIDER side-effect terms mapped to the drug or same-CAS compound identity.
| Side Effect | Drug Name | MedDRA Type | Concept ID |
|---|---|---|---|
| Abdominal discomfort | tranexamic | PT | C0232487 |
| Abdominal pain | tranexamic | LLT | C0000737 |
| Abdominal pain | tranexamic | PT | C0000737 |
| Abdominal tenderness | tranexamic | LLT | C0232498 |
| Abdominal tenderness | tranexamic | PT | C0232498 |
| Acute coronary syndrome | tranexamic | PT | C0948089 |
| Acute sinusitis | tranexamic | LLT | C0149512 |
| Acute sinusitis | tranexamic | PT | C0149512 |
| Allergic sinusitis | tranexamic | LLT | C0748726 |
| Allergic sinusitis | tranexamic | PT | C0748726 |
| Anaemia | tranexamic | LLT | C0002871 |
| Anaemia | tranexamic | PT | C0002871 |
| Anaphylactic shock | tranexamic | LLT | C0002792 |
| Anaphylactic shock | tranexamic | PT | C0002792 |
| Anaphylactic shock | tranexamic | PT | C0002792 |
| Anaphylactoid reaction | tranexamic | LLT | C0340865 |
| Anaphylactoid reaction | tranexamic | PT | C0340865 |
| Aneurysm | tranexamic | LLT | C0002940 |
| Aneurysm | tranexamic | PT | C0002940 |
| Angina pectoris | tranexamic | LLT | C0002962 |
| Angina pectoris | tranexamic | PT | C0002962 |
| Angiopathy | tranexamic | LLT | C0042373 |
| Angiopathy | tranexamic | PT | C0042373 |
| Aortic dissection | tranexamic | LLT | C0340643 |
| Aortic dissection | tranexamic | PT | C0340643 |
| Arrhythmia | tranexamic | LLT | C0003811 |
| Arrhythmia | tranexamic | PT | C0003811 |
| Arthralgia | tranexamic | LLT | C0003862 |
| Arthralgia | tranexamic | PT | C0003862 |
| Asthenia | tranexamic | PT | C0004093 |
| Atrial fibrillation | tranexamic | LLT | C0004238 |
| Atrial fibrillation | tranexamic | PT | C0004238 |
| Atrioventricular block | tranexamic | PT | C0004245 |
| Back pain | tranexamic | LLT | C0004604 |
| Back pain | tranexamic | PT | C0004604 |
| Block heart | tranexamic | LLT | C0018794 |
| Cardiac disorder | tranexamic | LLT | C0018799 |
| Cardiac disorder | tranexamic | PT | C0018799 |
| Cardiogenic shock | tranexamic | LLT | C0036980 |
| Cardiogenic shock | tranexamic | PT | C0036980 |
| Cardiovascular disorder | tranexamic | LLT | C0007222 |
| Cardiovascular disorder | tranexamic | PT | C0007222 |
| Central nervous system disorder | tranexamic | LLT | C0007682 |
| Cerebral thrombosis | tranexamic | LLT | C0079102 |
| Cerebral thrombosis | tranexamic | PT | C0079102 |
| Cerebrovascular accident | tranexamic | LLT | C0038454 |
| Cerebrovascular accident | tranexamic | PT | C0038454 |
| Chest pain | tranexamic | LLT | C0008031 |
| Chest pain | tranexamic | PT | C0008031 |
| Chromatopsia | tranexamic | LLT | C0474381 |
| Chromatopsia | tranexamic | PT | C0474381 |
| Colour blindness | tranexamic | LLT | C0242225 |
| Colour blindness | tranexamic | PT | C0242225 |
| Convulsion | tranexamic | LLT | C0036572 |
| Convulsion | tranexamic | PT | C0036572 |
| Cramp muscle | tranexamic | LLT | C0026821 |
| Deep vein thrombosis | tranexamic | LLT | C0149871 |
| Deep vein thrombosis | tranexamic | PT | C0149871 |
| Dermatitis atopic | tranexamic | LLT | C0011615 |
| Dermatitis atopic | tranexamic | PT | C0011615 |
| Diarrhoea | tranexamic | LLT | C0011991 |
| Diarrhoea | tranexamic | PT | C0011991 |
| Digestion impaired | tranexamic | LLT | C0232459 |
| Discomfort | tranexamic | PT | C0234215 |
| Discomfort | tranexamic | LLT | C0234215 |
| Discomfort | tranexamic | PT | C0234215 |
| Diuresis | tranexamic | LLT | C0012797 |
| Dizziness | tranexamic | LLT | C0012833 |
| Dizziness | tranexamic | PT | C0012833 |
| Dyspepsia | tranexamic | PT | C0013395 |
| Dyspnoea | tranexamic | LLT | C0013404 |
| Dyspnoea | tranexamic | PT | C0013404 |
| Embolism | tranexamic | LLT | C0013922 |
| Embolism | tranexamic | PT | C0013922 |
| Embolism | tranexamic | PT | C0013922 |
| Embolism | tranexamic | PT | C0013922 |
| Embolus | tranexamic | LLT | C1704212 |
| Eye disorder | tranexamic | LLT | C0015397 |
| Eye disorder | tranexamic | PT | C0015397 |
| Fatigue | tranexamic | LLT | C0015672 |
SOURCE
Rendered pharma page rows
FAQPage JSON-LD
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is Tranexamic Acid used for in pharmaceutical contexts?
Tranexamic Acid (CAS 1197-18-8) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for Tranexamic Acid?
Tranexamic Acid has 1,992 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Myoclonus, Wrong product administered, Generalised tonic-clonic seizure, Anaphylactic reaction, Haemorrhage. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is Tranexamic Acid also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for Tranexamic Acid with EU status "permitted".
What clinical phase is Tranexamic Acid in?
Tranexamic Acid is rendered with ChEMBL max phase 4 (approved).
What bioactivity targets are documented for Tranexamic Acid?
Tranexamic Acid has 5 bioactivity rows in this page query. Rendered target entries include Plasminogen.