Enoxolone
CAS 471-53-4
Enoxolone (CAS 471-53-4) is a Phase 2 pharmaceutical compound with 14 bioactivity targets and 0 adverse event associations.
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Clinical Development Phase
Highest clinical development phase rendered from the matched compound identifier rows.
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| - | IC50 | 44769.470873015875 nM | 126 | - |
| - | EC50 | 39345.71428571428 nM | 21 | - |
| - | Potency | 20187.724 nM | 20 | - |
| - | GI50 | 75563.07692307692 nM | 13 | - |
| - | Ki | 31571.428571428572 nM | 7 | - |
| - | MIC | 50 ug.mL-1 | 4 | - |
| - | IC50 | 7.31 ug.mL-1 | 1 | - |
| - | Kd | 250 nM | 1 | - |
| Arachidonate 5-lipoxygenase Enzyme |
IC50 | 4.61 | - | Homo sapiens |
| Tyrosine-protein phosphatase non-receptor type 1 Enzyme |
IC50 | 4.34 | - | Homo sapiens |
| Liver carboxylesterase 1 Enzyme |
IC50 | 4.68 | - | Homo sapiens |
| Protein kinase C eta type Kinase |
Kd | 6.6 | - | Homo sapiens |
| Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme |
IC50 | 8.91 | - | Homo sapiens |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme |
IC50 | 8.07 | - | Homo sapiens |
| Glycogen phosphorylase, muscle form Enzyme |
IC50 | 4.18 | - | Oryctolagus cuniculus |
| Beta-glucuronidase Enzyme |
IC50 | 4.01 | - | Rattus norvegicus |
| Cocaine esterase Enzyme |
IC50 | 4.16 | - | Homo sapiens |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme |
IC50 | 8.7 | - | Mus musculus |
| Aldo-keto reductase family 1 member B10 Enzyme |
IC50 | 5.31 | - | Homo sapiens |
| Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme |
IC50 | 7.05 | - | Rattus norvegicus |
| Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme |
IC50 | 6.44 | - | Rattus norvegicus |
| Tyrosine-protein phosphatase non-receptor type 11 Enzyme |
IC50 | 5.02 | - | Homo sapiens |
| Protein-tyrosine phosphatase 1C Enzyme |
IC50 | 4.18 | - | Homo sapiens |
| High mobility group protein B1 Nuclear other |
Kd | 4.06 | - | Homo sapiens |
| Lactoylglutathione lyase Enzyme |
Ki | 6.54 | - | Mus musculus |
| Beta-glucuronidase Enzyme |
IC50 | 4.92 | - | Escherichia coli |
IUPHAR Ligand-Target Data
Curated ligand-target interaction rows with action, affinity, and literature identifiers.
| Target | Action | Affinity | PubMed |
|---|---|---|---|
| hydroxysteroid 11-beta dehydrogenase 1 Hsd11b1 |
Inhibition | 7.050000190734863 pIC50 | 19914836 |
| hydroxysteroid 11-beta dehydrogenase 1 HSD11B1 |
Inhibition | 7.889999866485596 pIC50 | 18653260 |
| hydroxysteroid 11-beta dehydrogenase 1 HSD11B1 |
Inhibition | 7.539999961853027 pIC50 | 25590374 |
| hydroxysteroid 11-beta dehydrogenase 2 | Inhibition | 6.440000057220459 pIC50 | 19914836 |
| hydroxysteroid 11-beta dehydrogenase 2 HSD11B2 |
Inhibition | 8.920000076293945 pIC50 | 25590374 |
Drug Names / RxNorm
Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.
| Name | RxCUI | Type | Source |
|---|---|---|---|
| GLYCYRRHETINIC ACID | 1311506 | SU | MTHSPL |
| ENOXOLONE | 1311506 | SU | MTHSPL |
| enoxolone | 1311506 | SY | RXNORM |
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is Enoxolone used for in pharmaceutical contexts?
Enoxolone (CAS 471-53-4) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for Enoxolone?
No adverse-event association or SIDER side-effect rows are rendered for Enoxolone in this page query. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is Enoxolone also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for Enoxolone (Glycyrrhetinic Acid) with EU status "permitted".
What clinical phase is Enoxolone in?
Enoxolone is rendered with ChEMBL max phase 2.
What bioactivity targets are documented for Enoxolone?
Enoxolone has 26 bioactivity rows in this page query. Rendered target entries include Arachidonate 5-lipoxygenase, Tyrosine-protein phosphatase non-receptor type 1, Liver carboxylesterase 1, Protein kinase C eta type, Corticosteroid 11-beta-dehydrogenase isozyme 2.