Thiomersal
CAS 54-64-8
Thiomersal (CAS 54-64-8) is a pharmaceutical compound with 21 bioactivity targets and 20 adverse event associations.
Compound Identity
Matched identifiers and naming fields for the pharmaceutical compound record.
Cross-Reference to Cosmetics
Same-CAS ingredient record found in the cosmetics vertical.
Bioactivity & Target Interactions
Target-level activity records with assay counts, activity type, and measured value where present.
| Target | Activity | Value | Assays | Organism |
|---|---|---|---|---|
| Alpha-2A adrenergic receptor GPCR |
Ki | 6.699 | - | Homo sapiens |
| Sodium-dependent serotonin transporter Transporter |
Ki | 5.971 | - | Homo sapiens |
| Sodium-dependent noradrenaline transporter Transporter |
Ki | 6.035 | - | Homo sapiens |
| 5-hydroxytryptamine receptor 6 GPCR |
Ki | 5.56 | - | Homo sapiens |
| Alpha-2B adrenergic receptor GPCR |
Ki | 7.071 | - | Homo sapiens |
| D(3) dopamine receptor GPCR |
Ki | 7.538 | - | Homo sapiens |
| Alpha-2C adrenergic receptor GPCR |
Ki | 6.135 | - | Homo sapiens |
| Cytochrome P450 2D6 Enzyme |
IC50 | 5.523 | - | Homo sapiens |
| Adenosine receptor A3 GPCR |
Ki | 5.718 | - | Homo sapiens |
| Carbonic anhydrase 4 Enzyme |
Ki | 5.25 | - | Homo sapiens |
| Carbonic anhydrase 12 Enzyme |
Ki | 5.16 | - | Homo sapiens |
| Carbonic anhydrase 5A, mitochondrial Enzyme |
Ki | 5.14 | - | Homo sapiens |
| Carbonic anhydrase 5B, mitochondrial Enzyme |
Ki | 5.23 | - | Homo sapiens |
| Carbonic anhydrase 7 Enzyme |
Ki | 4.96 | - | Homo sapiens |
| Toll-like receptor 9 Membrane receptor |
IC50 | 5.2 | - | Homo sapiens |
| Carbonic anhydrase 3 Enzyme |
Ki | 5.2 | - | Homo sapiens |
| Carbonic anhydrase 6 Enzyme |
Ki | 5.29 | - | Homo sapiens |
| Carbonic anhydrase 14 Enzyme |
Ki | 5.18 | - | Homo sapiens |
| Mitogen-activated protein kinase 3 Kinase |
IC50 | 6.111 | - | Homo sapiens |
| Carbonic anhydrase 13 Enzyme |
Ki | 5.16 | - | Homo sapiens |
| Beta-lactamase Enzyme |
IC50 | 4.77 | - | Pseudomonas aeruginosa |
Adverse Event Associations
DrugCentral / FAERS disproportionality signal rows matched to this compound.
| Reaction PT | Drug AE | LLR | MedDRA |
|---|---|---|---|
| Gastrointestinal toxicity | 91 | 425.008 | 10059024 |
| Pulmonary toxicity | 90 | 390.847 | 10061924 |
| Joint injury | 90 | 319.423 | 10060820 |
| Neoplasm malignant | 91 | 297.281 | 10028997 |
| Hepatotoxicity | 91 | 279.506 | 10019851 |
| C-reactive protein abnormal | 87 | 273.322 | 10068559 |
| Therapy non-responder | 97 | 245.538 | 10051082 |
| Joint stiffness | 77 | 236.727 | 10023230 |
| Musculoskeletal pain | 92 | 225.305 | 10028391 |
| Drug hypersensitivity | 127 | 207.256 | 10013700 |
| Musculoskeletal stiffness | 91 | 164.139 | 10052904 |
| Therapeutic product effect incomplete | 81 | 157.55 | 10082200 |
| Treatment failure | 90 | 152.054 | 10066901 |
| Infection | 91 | 133.044 | 10021789 |
| Arthropathy | 82 | 128.138 | 10003285 |
| Joint swelling | 90 | 118.397 | 10023232 |
| Pain in extremity | 92 | 113.61 | 10033425 |
| Drug intolerance | 80 | 99.041 | 10061822 |
| Condition aggravated | 92 | 88.513 | 10010264 |
Association rows are source-linked signal records, not incidence rates or clinical causality claims.
Drug Names / RxNorm
Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.
| Name | RxCUI | Type | Source |
|---|---|---|---|
| THIMEROSAL | 10472 | SU | MTHSPL |
| thimerosal | 10472 | SU | MTHSPL |
| thiomersal | 10472 | SY | RXNORM |
Frequently Asked Questions
Short answers generated only from the same visible source-linked rows on this page.
What is Thiomersal used for in pharmaceutical contexts?
Thiomersal (CAS 54-64-8) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.
What are the known adverse events for Thiomersal?
Thiomersal has 20 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Gastrointestinal toxicity, Pulmonary toxicity, Joint injury, Neoplasm malignant, Hepatotoxicity. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.
Is Thiomersal also used in cosmetics?
Yes. The ingredients table has a same-CAS cosmetic profile for Thimerosal (Thiomersal) with EU status "prohibited".
What clinical phase is Thiomersal in?
No phase 1-4 clinical development badge is rendered for Thiomersal because the matched compound identifier rows do not contain a max-phase value.
What bioactivity targets are documented for Thiomersal?
Thiomersal has 21 bioactivity rows in this page query. Rendered target entries include Alpha-2A adrenergic receptor, Sodium-dependent serotonin transporter, Sodium-dependent noradrenaline transporter, 5-hydroxytryptamine receptor 6, Alpha-2B adrenergic receptor.