Cosmetic cross-reference

Alpha-Tocopherol

CAS 59-02-9

Alpha-Tocopherol (CAS 59-02-9) is a pharmaceutical compound with 2 bioactivity targets and 467 adverse event associations.

SOURCE NLM DailyMed

Label records

SOURCE EMBL-EBI ChEMBL

Bioactivity

SOURCE DrugCentral

Adverse signals

467

SOURCE IUPHAR/BPS

PubMed IDs

SOURCE EMBL-EBI ChEMBL B25820EEF0F0

Compound Identity

Matched identifiers and naming fields for the pharmaceutical compound record.

Primary Name

Alpha-Tocopherol

CAS Number

59-02-9

UNII

N9PR3490H9

InChIKey

GVJHHUAWPYXKBD-IEOSBIPESA-N

ChEMBL ID

CHEMBL47

Molecule Type

Small molecule

Source Match

EMBL-EBI ChEMBL (INCHIKEY)

Synonyms and normalized names

.ALPHA.-TOCOPHEROL, D-

natural product

SOURCE Ingredients table / CosIng profile same-CAS cross-reference

Cross-Reference to Cosmetics

Same-CAS ingredient record found in the cosmetics vertical.

This substance also has a cosmetic safety profile →

SOURCE EMBL-EBI ChEMBL 9 bioactivity rows

Bioactivity & Target Interactions

Target-level activity records with assay counts, activity type, and measured value where present.

Target	Activity	Value	Assays	Organism
-	IC50	25924.666666666668 nM	45	-
-	IC50	14.892 ug.mL-1	9	-
-	Potency	8987.016666666666 nM	6	-
-	EC50	10.200000000000001 ug.mL-1	3	-
-	EC50	500 nM	2	-
-	EC50	10.1 ug	1	-
-	Kd	2420 nM	1	-
Glutathione S-transferase P Enzyme	IC50	6.3	-	Homo sapiens
Alpha-tocopherol transfer protein Transporter	Kd	5.62	-	Homo sapiens

SOURCE DrugCentral 80 associations

Adverse Event Associations

DrugCentral / FAERS disproportionality signal rows matched to this compound.

Reaction PT	Drug AE	LLR	MedDRA
Macular degeneration	188	327.293	10025409
Therapy cessation	204	280.418	10065154
Muscle spasticity	123	168.153	10028335
Appendicolith	79	162.416	10074458
Electric shock	49	148.089	10014357
Blood phosphorus increased	74	130.239	10050196
Toxicity to various agents	35	112.038	10070863
Chronic sinusitis	76	108.888	10009137
Fractional exhaled nitric oxide increased	35	108.391	10078429
Ear pain	114	108.125	10014020
Intervertebral discitis	51	101.445	10060738
Weight decreased	443	99.856	10047895
Drug interaction	43	97.908	10013710
Peripheral swelling	360	96.84	10048959
Post-traumatic stress disorder	53	95.735	10036316
Blood uric acid increased	69	95.512	10005861
Appendicitis	81	93.821	10003011
Infective pulmonary exacerbation of cystic fibrosis	66	91.178	10070608
Dry mouth	170	87.939	10013781
Temperature intolerance	60	86.641	10057040
Paraesthesia oral	77	84.55	10057372
Respiratory disorder	118	82.427	10038683
Body temperature increased	114	82.299	10005911
Night sweats	125	81.752	10029410
Back pain	361	79.399	10003988
Post cholecystectomy syndrome	22	77.259	10057229
Presbyacusis	36	76.251	10036626
Procedural pain	76	76.193	10064882
Demyelination	50	70.945	10012305
Acute kidney injury	94	70.834	10069339
Insomnia	312	70.772	10022437
Constipation	338	70.357	10010774
Dry eye	101	70.253	10013774
Diarrhoea	785	69.81	10012735
Pleural thickening	35	69.633	10035616
Myoglobin blood increased	36	68.036	10028625
Ventricular fibrillation	81	67.319	10047290
Blood magnesium increased	36	67.008	10005655
Blood immunoglobulin A increased	24	65.05	10005586
Abdominal pain upper	275	63.994	10000087
Incorrect route of product administration	91	63.076	10081202
Multiple sclerosis	73	62.83	10028245
Pleural fibrosis	36	60.739	10035600
Stress	135	60.381	10042209
Hand deformity	6	59.847	10061194
Vitamin B12 increased	24	59.435	10047610
Sensation of foreign body	40	59.414	10061549
Granulocyte count increased	23	57.496	10018683
Glomerular filtration rate increased	23	57.027	10018359
Pemphigus	12	56.996	10034280

Association rows are source-linked signal records, not incidence rates or clinical causality claims.

SOURCE NLM RxNorm 5 name rows

Drug Names / RxNorm

Normalized drug-name vocabulary rows, RxCUIs, and source abbreviations.

Name	RxCUI	Type	Source
ALPHA-TOCOPHEROL	237099	SU	MTHSPL
Alpha-Tocopherol	237099	SU	MTHSPL
alpha-tocopherol	237099	SU	MTHSPL
Alpha-tocopherol	237099	SU	MTHSPL
.ALPHA.-TOCOPHEROL, D-	237099	SU	MTHSPL

SOURCE Rendered pharma page rows FAQPage JSON-LD

Frequently Asked Questions

Short answers generated only from the same visible source-linked rows on this page.

What is Alpha-Tocopherol used for in pharmaceutical contexts?

Alpha-Tocopherol (CAS 59-02-9) is rendered as a pharmaceutical compound from the matched source rows; no DailyMed product-name rows are present in this page query.

What are the known adverse events for Alpha-Tocopherol?

Alpha-Tocopherol has 467 DrugCentral/FAERS adverse event associations. Rendered reaction terms include Macular degeneration, Therapy cessation, Muscle spasticity, Appendicolith, Electric shock. Signal rows are source-linked records and should not be read as incidence rates or causality conclusions.

Is Alpha-Tocopherol also used in cosmetics?

Yes. The ingredients table has a same-CAS cosmetic profile for Tocopherol with EU status "permitted".

What clinical phase is Alpha-Tocopherol in?

No phase 1-4 clinical development badge is rendered for Alpha-Tocopherol because the matched compound identifier rows do not contain a max-phase value.

What bioactivity targets are documented for Alpha-Tocopherol?

Alpha-Tocopherol has 9 bioactivity rows in this page query. Rendered target entries include Glutathione S-transferase P, Alpha-tocopherol transfer protein.