SCCS/0952/05
11 NOAEL rows
Dihydroxyindole (INCI name)
Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/0952/05.
Opinion Number
SCCS/0952/05
NOAEL Rows
11
Substances Covered
1
Substance(s) Covered
Dihydroxyindole (INCI name)
NOAEL Values Extracted from This Opinion
| Substance | Endpoint | Value | Study | Source |
|---|---|---|---|---|
|
Dihydroxyindole (INCI name)
3131-52-0
|
NOAEL | 1.5 mg/kg bw/d | Chronic |
Regulatory source
p.15
SCCS Opinion
|
|
Dihydroxyindole (INCI name)
3131-52-0
|
NOAEL | 1.5 mg/kg bw/d | Chronic |
Regulatory source
p.15
SCCS Opinion
|
|
Dihydroxyindole (INCI name)
3131-52-0
|
NOAEL | 3 mg/kg bw/day | rat |
Regulatory source
p.14
SCCS Opinion
|
|
Dihydroxyindole (INCI name)
3131-52-0
|
NOAEL | 10 mg/kg bw/day | rat |
Regulatory source
p.14
SCCS Opinion
|
|
Dihydroxyindole (INCI name)
3131-52-0
|
dermal absorption | 0.012 mg/kg |
dermal absorption rat dermal 13-week |
Regulatory source
p.23
SCCS Opinion
|
|
Dihydroxyindole (INCI name)
3131-52-0
|
dermal absorption | 1.5 mg/kg |
dermal absorption rat dermal 13-week |
Regulatory source
p.23
SCCS Opinion
|
|
Dihydroxyindole (INCI name)
3131-52-0
|
dermal absorption | 1.5 mg/kg |
dermal absorption rat dermal 13-week |
Regulatory source
p.23
SCCS Opinion
|
|
Dihydroxyindole (INCI name)
3131-52-0
|
repeated dose toxicity | 10 mg/kg bw/day |
repeated dose toxicity rat oral subchronic |
Regulatory source
p.15
SCCS Opinion
|
|
Dihydroxyindole (INCI name)
3131-52-0
|
repeated dose toxicity | 500 mg/kg bw |
repeated dose toxicity rat oral subchronic |
Regulatory source
p.24
SCCS Opinion
|
|
Dihydroxyindole (INCI name)
3131-52-0
|
reproductive toxicity | 15 mg/kg bw/d |
reproductive toxicity rat dermal |
Regulatory source
p.21
SCCS Opinion
|
|
Dihydroxyindole (INCI name)
3131-52-0
|
reproductive toxicity | 100 mg/kg bw/day |
reproductive toxicity rat developmental |
Regulatory source
p.20
SCCS Opinion
|
Safety Conclusion
No matching safety conclusion table row was found. Available SCCS data from noael_studies is shown above.