SCCS/1029/06 1 NOAEL row Safety conclusion

s classified, Toluene

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1029/06.

Opinion Number
SCCS/1029/06
NOAEL Rows
1
Substances Covered
2

Substance(s) Covered

s classified Toluene

NOAEL Values Extracted from This Opinion

Substance Endpoint Value Study Source
s classified
108-88-3
reproductive toxicity 34 ppm reproductive toxicity
human
inhalation
chronic
Regulatory source
p.7
SCCS Opinion

Safety Conclusion

sccs_opinions
Although specific information related to the effects in children is limited and because of the low and occasional exposure, the SCCP is of the opinion that the presence of toluene as a solvent in nail cosmetics does not pose a risk to the health of all groups of consumers, independent of their age.

Key concerns: Exposure-driven evaluation of acute inhalation effects and reproductive toxicity; occasional consumer exposure of 1-4 ppm considered safe; specific information on effects in children is limited.

Opinion date: 10 October 2006

Source Citation