SCCS/1123/07 12 NOAEL rows Safety conclusion

1-Naphthol (COLIPA A17)

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1123/07.

Opinion Number
SCCS/1123/07
NOAEL Rows
12
Substances Covered
1

Substance(s) Covered

1-Naphthol (COLIPA A17)

NOAEL Values Extracted from This Opinion

Substance Endpoint Value Study Source
90-15-3
90-15-3
 NOAEL 20 mg/kg bw dermal
90 day
Regulatory source
p.5
SCCS Opinion
90-15-3
90-15-3
 NOAEL 130 mg/kg bw/day rat
90-days
Regulatory source
p.15
SCCS Opinion
90-15-3
90-15-3
 NOAEL 130 mg/kg bw rat
90-days
Regulatory source
p.15
SCCS Opinion
90-15-3
90-15-3
 dermal absorption 20 mg/kg bw dermal absorption
rat
oral
Regulatory source
p.24
SCCS Opinion
90-15-3
90-15-3
 dermal absorption 20 mg/kg bw dermal absorption
rat
oral
Regulatory source
p.24
SCCS Opinion
90-15-3
90-15-3
 developmental toxicity 20 mg/kg bw/day developmental toxicity
human
developmental
Regulatory source
p.23
SCCS Opinion
90-15-3
90-15-3
 developmental toxicity 65 mg/kg bw/day developmental toxicity
rat
developmental
Regulatory source
p.24
SCCS Opinion
90-15-3
90-15-3
 developmental toxicity 130 mg/kg bw developmental toxicity
rat
developmental
Regulatory source
p.24
SCCS Opinion
90-15-3
90-15-3
 developmental toxicity 400 mg/kg bw/day developmental toxicity
human
developmental
Regulatory source
p.23
SCCS Opinion
90-15-3
90-15-3
 developmental toxicity 400 mg/kg bw/day developmental toxicity
rat
developmental
Regulatory source
p.24
SCCS Opinion
90-15-3
90-15-3
 repeated dose toxicity 100 mg/kg bw/day repeated dose toxicity
rat
oral
Sub-chronic
Regulatory source
p.14
SCCS Opinion
90-15-3
90-15-3
 repeated dose toxicity 100 mg/kg bw/day repeated dose toxicity
rat
oral
Sub-chronic
Regulatory source
p.14
SCCS Opinion

Safety Conclusion

sccs_opinions Max 2.0% on the head
The SCCP is of the opinion that, apart from the risks associated with the use of a strong sensitiser, the use of 1-naphthol itself in oxidative hair dye formulations at a maximum concentration of 2.0% on the head, does not pose any other risk to the health of the consumer.

Key concerns: Strong sensitiser. 1-Naphthol itself has no mutagenic potential, but genotoxicity/mutagenicity studies in finished hair dye formulations should be undertaken per SCCNFP/SCCP opinions and Notes of Guidance.

Opinion date: 2008-04-15

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en