SCCS/1366/10 17 NOAEL rows Safety conclusion

2,7-Naphthalenediol

Structured SCCS opinion summary generated from source-matched D1 rows for SCCS/1366/10.

Opinion Number

SCCS/1366/10

NOAEL Rows

Substances Covered

Substance(s) Covered

2,7-Naphthalenediol

NOAEL Values Extracted from This Opinion

Substance	Endpoint	Value	Study	Source
2,7-Naphthalenediol 582-17-2	NOAEL	60 mg/kg bw/day	rat oral 5 weeks	Regulatory source p.14 SCCS Opinion
2,7-Naphthalenediol 582-17-2	NOAEL	60 mg/kg bw	rat oral 11 week	Regulatory source p.20 SCCS Opinion
2,7-Naphthalenediol 582-17-2	NOAEL	65 mg/kg bw/day	human	Regulatory source p.21 SCCS Opinion
2,7-Naphthalenediol 582-17-2	NOAEL	65 mg/kg bw/day	human	Regulatory source p.21 SCCS Opinion
2,7-Naphthalenediol 582-17-2	NOAEL	70 mg/kg bw/day	rat 90 days	Regulatory source p.15 SCCS Opinion
2,7-Naphthalenediol 582-17-2	NOAEL	70 mg/kg bw/day	rat 90 days	Regulatory source p.15 SCCS Opinion
2,7-Naphthalenediol 582-17-2	NOAEL	585 mg/kg bw/day	human	Regulatory source p.21 SCCS Opinion
2,7-Naphthalenediol 582-17-2	dermal absorption	0.04 mg/kg bw/d	dermal absorption rat oral	Regulatory source p.22 SCCS Opinion
2,7-Naphthalenediol 582-17-2	dermal absorption	0.06 mg/kg bw/d	dermal absorption rat oral	Regulatory source p.22 SCCS Opinion
2,7-Naphthalenediol 582-17-2	dermal absorption	65 mg/kg bw/d	dermal absorption rat oral	Regulatory source p.22 SCCS Opinion
2,7-Naphthalenediol 582-17-2	dermal absorption	65 mg/kg bw/d	dermal absorption rat oral	Regulatory source p.22 SCCS Opinion
2,7-Naphthalenediol 582-17-2	dermal absorption	65 mg/kg bw/d	dermal absorption rat oral	Regulatory source p.22 SCCS Opinion
2,7-Naphthalenediol 582-17-2	dermal absorption	65 mg/kg bw/d	dermal absorption rat oral	Regulatory source p.22 SCCS Opinion
2,7-Naphthalenediol 582-17-2	irritation	65 mg/kg bw/day	irritation rat 90 day	Regulatory source p.22 SCCS Opinion
2,7-Naphthalenediol 582-17-2	irritation	70 mg/kg bw/day	irritation rat oral 90 day	Regulatory source p.22 SCCS Opinion
2,7-Naphthalenediol 582-17-2	irritation	70 mg/kg bw/day	irritation rat 90 day	Regulatory source p.22 SCCS Opinion
2,7-Naphthalenediol 582-17-2	irritation	70 mg/kg bw/day	irritation rat 90 day	Regulatory source p.22 SCCS Opinion

Safety Conclusion

sccs_opinions Max 1%

The SCCP is of the opinion that 2,7-Naphthalenediol as an ingredient in oxidative and non-oxidative hair dye formulations at a maximum on-head concentration of 1% does not pose a risk to the health of the consumer, apart from its sensitising potential.

Key concerns: Sensitising potential. No mutagenic potential in vivo; genotoxicity/mutagenicity studies in finished formulations should be undertaken per SCCNFP/SCCP opinions and Notes of Guidance.

Opinion date: 21 September 2010

Source Citation

Primary source https://health.ec.europa.eu/scientific-committees/scientific-committee-consumer-safety-sccs/sccs-opinions_en