EFSA toxicology reference values
1R,2S,5R-isopulegol
SOURCE
efsa openfoodtox 3 0 export repository
1R,2S,5R-isopulegol (CAS 89-79-2). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
1R,2S,5R-isopulegol is a cannabis analyte contaminant represented in the cannabis public dataset.
CAS 89-79-2
Cannabis Analyte
Substance Identity
Analyte identity and classification used for this cannabis substance page.
SOURCE
efsa substances
Analyte name
1R,2S,5R-isopulegol
CAS number
89-79-2
Contaminant class
Cannabis Analyte
Contaminant Class Badge
Color-coded cannabis class signal for scanning pesticide, metal, solvent, mycotoxin, and potency pages.
SOURCE
State Cannabis Regulations
Cannabis Analyte
Cannabis contaminant class used to group state testing rows.
Dataset Snapshot
Compact public-data summary for page quality, state coverage, lab rows, and potency sample groups.
SOURCE
cannabis page data
Quality score
2
thin
Jurisdictions
0
No state rows
Lab/analyte rows
0
0 failed (-)
Potency samples
0
89-79-2
EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
SOURCE
efsa openfoodtox 3 0 export repository
1R,2S,5R-isopulegol
CAS 89-79-2 / mono-constituent substance
C10H18O / 3 dossier(s)
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
SOURCE
efsa openfoodtox 3 0 export repository
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| TTC Cramer Class I | 30 µg/kg bw/day | consumers | - | - |
| TTC Cramer Class I | 30 µg/kg bw/day | consumers | - | - |
| margin of safety | 2,700 other: | consumers | a0090ed9-1d65-486a-945c-ef41c3fe8027 | - |
| Incomplete dataset | - | workers | - | - |
| Incomplete dataset | - | consumers | - | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
SOURCE
efsa openfoodtox 3 0 export repository
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| sub-chronic toxicity: oral | rat | oral: feed | 38 other: | - |
| Carcinogenicity_EU_PPP | - | - | - | Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the supplementary information submitted on the safety of 37 compounds belonging to different chemical groups, when used as sensory additives (flavourings) in feed for all animal species formerly assessed by the Panel in the context of the re-evaluation of these feed additives. |
| Carcinogenicity_EU_PPP | - | - | - | The EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. |
| Carcinogenicity_EU_PPP | - | - | - | The Scientific Panel on Food Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217 EC and its consecutive amendments. Six substances were evaluated by the JECFA in the group of pulegone and structurally related substances. Pulegone (JECFA-no: 753) and menthofuran (JECFA-no: 758) are in Annex III of Regulation (EC) No 1334/2008 of the European Parliament and of the Council (EC, 2008) and accordingly cannot be used as flavouring substances in the EU. p-Mentha-1,4(8)-dien-3-one [FL-no: 07.127] is an alpha,beta-unsaturated ketone which was considered together with other alpha,beta-unsaturated ketones in FGE.213, in which it was concluded that additional genotoxicity data were required. The Panel considered the remaining three substances in this FGE, isopulegol [FL-no: 02.067], isopulegone [FL-no: 07.067] and isopulegyl acetate [FL-no: 09.219]). However, as there are some data indicating that isopulegone might be partly isomerised to pulegone via a minor metabolic pathway (Gordon et al., 1987; McClanahan et al., 1988), the Panel also considered data on pulegone and the metabolically related menthofuran and took into account the SCF Opinion on pulegone and menthofuran (SCF, 2002g), later revised by the European Food Safety Authority (EFSA) based on additional data (EFSA, 2005). |
| Genetic Toxicity | - | - | - | The EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. |
| Genetic Toxicity | - | - | - | The Scientific Panel on Food Food Contact Materials, Enzymes, Flavourings and Processing Aids (the Panel) was asked to provide scientific advice to the Commission on the implications for human health of chemically defined flavouring substances used in or on foodstuffs in the Member States. In particular, the Panel was requested to consider the Joint FAO/WHO Expert Committee on Food Additives (the JECFA) evaluations of flavouring substances assessed since 2000, and to decide whether no further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. These flavouring substances are listed in the Register, which was adopted by Commission Decision 1999/217 EC and its consecutive amendments. Six substances were evaluated by the JECFA in the group of pulegone and structurally related substances. Pulegone (JECFA-no: 753) and menthofuran (JECFA-no: 758) are in Annex III of Regulation (EC) No 1334/2008 of the European Parliament and of the Council (EC, 2008) and accordingly cannot be used as flavouring substances in the EU. p-Mentha-1,4(8)-dien-3-one [FL-no: 07.127] is an alpha,beta-unsaturated ketone which was considered together with other alpha,beta-unsaturated ketones in FGE.213, in which it was concluded that additional genotoxicity data were required. The Panel considered the remaining three substances in this FGE, isopulegol [FL-no: 02.067], isopulegone [FL-no: 07.067] and isopulegyl acetate [FL-no: 09.219]). However, as there are some data indicating that isopulegone might be partly isomerised to pulegone via a minor metabolic pathway (Gordon et al., 1987; McClanahan et al., 1988), the Panel also considered data on pulegone and the metabolically related menthofuran and took into account the SCF Opinion on pulegone and menthofuran (SCF, 2002g), later revised by the European Food Safety Authority (EFSA) based on additional data (EFSA, 2005). |
| Genetic Toxicity | - | - | - | Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the supplementary information submitted on the safety of 37 compounds belonging to different chemical groups, when used as sensory additives (flavourings) in feed for all animal species formerly assessed by the Panel in the context of the re-evaluation of these feed additives. |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
SOURCE
core public cross-reference
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
SOURCE
page FAQ dataset
What is the regulatory limit for 1R,2S,5R-isopulegol in cannabis?
1R,2S,5R-isopulegol does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for 1R,2S,5R-isopulegol?
1R,2S,5R-isopulegol does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for 1R,2S,5R-isopulegol?
1R,2S,5R-isopulegol has 5 EFSA OpenFoodTox reference value rows in the cannabis database, including TTC Cramer Class I, margin of safety, Incomplete dataset.
Is 1R,2S,5R-isopulegol also regulated in cosmetics or food?
1R,2S,5R-isopulegol has a cosmetics ingredient cross-reference with EU status restricted. EFSA food/toxicology context is available on this page.