Is Isopulegol safe in cosmetics?
Isopulegol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
MODERATE
Cosmetic Ingredient
Isopulegol
Also known as: (-)-Isopulegol, EINECS 201-940-6, FEMA No. 2962, p-Menth-8-en-3-ol, (1R,3R,4S)-(-)-, p-8(9)-Menthen-3-ol (+5 more)
INCI: ISOPULEGOL
Isopulegol (CAS 89-79-2) is a cosmetic cosmetic ingredient functioning as Fragrance (perfuming agent). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Cross-Vertical Regulatory Divergence
Isopulegol is classified GHS Danger (H302, H315, H319, H351, H372, H226, H318) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Fragrance (perfuming agent)
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
(1R,2S,5R)-5-methyl-2-prop-1-en-2-ylcyclohexan-1-ol
InChIKey
ZYTMANIQRDEHIO-KXUCPTDWSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Allowed - no specific prohibition. Regulated generally as a fragrance ingredient.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopulegol.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5184 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
755
Source: WHO/JECFA
JECFA Evaluation
ISOPULEGOL | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/56 | FAS 46-JECFA 55/221
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Isopulegol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
(-)-Isopulegol
EINECS 201-940-6
FEMA No. 2962
p-Menth-8-en-3-ol, (1R,3R,4S)-(-)-
p-8(9)-Menthen-3-ol
5-Methyl-2-(1-methylethenyl)cyclohexanol, (1R-(1alpha,2beta,5alpha))-
l-Isopulegol
iso-Pulegol
(-)-L-Isopulegol
UNII-3TH92O3BXN
Chemical Function
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
active_ingredient; Europe; Pesticides
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ISOPULEGOL
ChEMBL ID
CHEMBL237994
Frequently Asked Questions
Is Isopulegol allowed in the EU?
Isopulegol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopulegol do in cosmetics?
Isopulegol functions as: Fragrance (perfuming agent). It is classified as a cosmetic ingredient in our database. CAS number: 89-79-2.
Is Isopulegol used outside cosmetics?
Isopulegol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isopulegol have different safety status in cosmetics vs industrial chemicals?
Isopulegol is classified GHS Danger (H302, H315, H319, H351, H372, H226, H318) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Isopulegol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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