EFSA toxicology reference values
methyleugenol
methyleugenol (CAS 93-15-2). Cannabis testing data across 0 states. Action levels when present, testing requirements, compliance status.
methyleugenol is a cannabis analyte contaminant represented in the cannabis public dataset.
Substance Identity
Analyte identity and classification used for this cannabis substance page.
Contaminant Class Badge
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Dataset Snapshot
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EFSA Substance Identity
EFSA substance identity rows matched by chemical name or CAS.
EFSA Reference Values
Reference values from efsa_reference_values_v2 for toxicology and food-safety context.
| Descriptor | Value | Population | Endpoint | Body |
|---|---|---|---|---|
| MOE | 39,467 other: | dog | 87a6befd-0205-4e8c-8ea2-907ea6a0b9b4 | - |
| MOE | 164,444 other: | horse | 87a6befd-0205-4e8c-8ea2-907ea6a0b9b4 | - |
EFSA Study Results
Endpoint-level study rows from efsa_study_results matched to this substance.
| Endpoint | Species | Route | Effect | Assessment |
|---|---|---|---|---|
| chronic toxicity: other route | other: | - | 22.2 mg/kg bw/day | - |
| basic toxicokinetics in vivo | - | - | - | - |
| in vitro gene mutation study in mammalian cells | - | - | - | DNA repair was induced by methyleugenol in primary hepatocytes from rats and mice (Howes et al., 1990; Chan and Caldwell, 1992; Burkey et al., 2000). |
| in vitro gene mutation study in mammalian cells | - | - | - | In Chinese hamster ovary (CHO) cells, sister chromatid exchange (SCE) was induced by methyleugenol exposure in the presence and absence of microsomal activation and chromosomal aberrations only in the presence of microsomal activation (NTP, 2000). |
| in vitro gene mutation study in mammalian cells | - | - | - | DNA repair was induced by methyleugenol in primary hepatocytes from rats and mice (Howes et al., 1990; Chan and Caldwell, 1992; Burkey et al., 2000). |
| in vitro gene mutation study in bacteria | - | - | - | Positive results were obtained in a modified strain of S. Typhimurium (TA100-hSULT1C2) expressing sulfotransferase (Honda et al., 2016), indicating that the formation of sulfate esters plays a key role in the genotoxicity of alkenylbenzenes. |
| in vitro gene mutation study in mammalian cells | - | - | - | The induction of malignant transformation by methyleugenol was demonstrated in Syrian hamster ovary cells (Kerkaert et al., 1996). |
| genetic toxicity in vitro, other | - | - | - | The DNA damaging effects could be inhibited by addition of sulfotransferase inhibitors. DNA adducts were detected after i.p. injection of methyleugenol in the livers of female CD-1 mice and treatment of human HepG2 cells in vitro with methyleugenol (Zhou et al., 2007). |
| in vitro gene mutation study in bacteria | - | - | - | Positive results were obtained in a modified strain of Salmonella Typhimurium (TA100-hSULT1C2) expressing sulfotransferase (Honda et al., 2016), indicating that the formation of sulfate esters plays a key role in the genotoxicity of alkenylbenzenes. |
| genetic toxicity in vitro, other | - | - | - | The DNA damaging effects could be inhibited by addition of sulfotransferase inhibitors. DNA adducts were detected after i.p. injection of methyleugenol in the livers of female CD-1 mice and treatment of human HepG2 cells in vitro with methyleugenol (Zhou et al., 2007). |
| genetic toxicity in vitro, other | - | - | - | In Chinese hamster ovary (CHO) cells, sister chromatid exchange (SCE) was induced by methyleugenol exposure in the presence and absence of microsomal activation and chromosomal aberrations only in the presence of microsomal activation (NTP, 2000). |
| genetic toxicity in vivo, other | mouse | intraperitoneal | - | The DNA damaging effects could be inhibited by addition of sulfotransferase inhibitors. DNA adducts were detected after i.p. injection of methyleugenol in the livers of female CD-1 mice and treatment of human HepG2 cells in vitro with methyleugenol (Zhou et al., 2007). |
Cross-Reference to Chemicals / Cosmetics / Food
Internal cross-vertical links connecting cannabis rows to chemical, cosmetics, and EFSA food/toxicology context.
Frequently Asked Questions
FAQ answers are generated from the same fetched cannabis, EFSA, cosmetics, and chemical rows rendered above.
What is the regulatory limit for methyleugenol in cannabis?
methyleugenol does not have a numeric cannabis_contaminant_tests range in the fetched page data. The current page query does not expose a separate action-limit column.
Which states test for methyleugenol?
methyleugenol does not have state-level cannabis testing rows in the fetched page data.
What are the EFSA reference values for methyleugenol?
methyleugenol has 2 EFSA OpenFoodTox reference value rows in the cannabis database, including MOE.
Is methyleugenol also regulated in cosmetics or food?
methyleugenol has a cosmetics ingredient cross-reference with EU status prohibited. EFSA food/toxicology context is available on this page.