Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
9 study endpoints found for Methyl Eugenol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 18 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
| NOAEL | 30 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 37 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| NOAEL | 37 mg/kg bw/day | oral | mouse | Carcinogenicity | COSMOS_DB |
| LOAEL | 10 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
| LOAEL | 30 mg/kg bw/day | oral | mouse | Subchronic | COSMOS_DB |
| dose_tested | 18 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Expert Verdict
Methyl eugenol is prohibited as an intentional fragrance ingredient in the EU (Annex II) due to genotoxic carcinogen potential. Naturally occurring trace amounts in essential oils have defined permissible limits; formulators must verify essential oil contributions remain below regulatory thresholds. Restricted in the US with case-by-case evaluation for natural traces.
Regulatory Flags
Frequently Asked Questions
Is Methyl Eugenol safe in cosmetics?
Methyl eugenol is prohibited as an intentional fragrance ingredient in the EU (Annex II) due to genotoxic carcinogen potential. Naturally occurring trace amounts in essential oils have defined permissible limits; formulators must verify essential oil contributions remain below regulatory thresholds. Restricted in the US with case-by-case evaluation for natural traces. The EU classifies Methyl Eugenol as "prohibited". Safety rating: POOR. 9 toxicological study endpoint(s) are available in our database.
Is Methyl Eugenol allowed in the EU?
Methyl Eugenol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Eugenol do in cosmetics?
Methyl Eugenol functions as: fragrance. It is classified as a Fragrance in our database. CAS number: 93-15-2.
What is the Margin of Safety for Methyl Eugenol?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl Eugenol?
The NOAEL (No Observed Adverse Effect Level) for Methyl Eugenol is 18 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 9 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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