What is the GHS hazard classification for Benzaldehyde?
Benzaldehyde (CAS 100-52-7) is classified under EU CLP Annex VI as Acute Tox. 4 * with signal word Warning. Hazard statements: H302. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Benzaldehyde
Also known as: Benzene carboxaldehyde, Bitter almond oil, synthetic, EINECS 202-860-4, EPA Pesticide Chemical Code 008601, NCI-C56133 (+14 more)
CAS 100-52-7
Benzaldehyde (CAS 100-52-7) is a chemical substance with GHS signal word Warning; key hazard signal: H302. Key regulatory status: REACH registered, 60 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
NOAEL studies
NOAEL studies
54
SOURCE
Chemical inventory jurisdictions
Regulatory lists
60
SOURCE
EU CLP Annex VI
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Benzaldehyde
CAS Number
100-52-7
Molecular Formula
C7H6O
InChI Key
HUMNYLRZRPPJDN-UHFFFAOYSA-N
Monoisotopic Mass
106.041865
Synonyms
Benzene carboxaldehydeBitter almond oil, syntheticEINECS 202-860-4EPA Pesticide Chemical Code 008601NCI-C56133UNII-TA269SD04TArtificial bitter almond oilArtificial essential oil of almondBEZBenzadehydeBenzanoaldehydeBenzene carbaldehyde
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 * | H302 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
WHO/JECFA
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Flammable liquid and vapour Harmful if swallowed or in contact with skin Toxic to aquatic life |
| Short-term Effects | The substance is irritating to the eyes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceDeodorizerFlavouring and nutrientNo specific technical functionSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
60 records
| List | Keyword | Source |
|---|---|---|
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cons electronics mech appliances and machinery; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - home office - pens and markers; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - fabric treatment and dye; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Furniture and Furnishings | Danish Environmental Protection Agency | Danish EPA |
| artificial_saliva; detected; emissions; Europe; Other indirect contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| consumer_product; detected | Elsevier | CPCat |
| detected; Europe; Personal care - nails - nail polish | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - nails - nail polish | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| detected; emissions; Europe; Other indirect contact consumer goods; water | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Arts and crafts/Office supplies - children's art and toys - modeling clay; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 54 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=5 | mg/kg | ADI | oral | Human | WHO/JECFA |
| 259.9 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 59 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 300.3 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 488.4 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 2.167 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 0.4167 | % | Concentration, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =9.8 | mg/m3 | DNEL local | inhalation | Human | ToxValDB GESTIS DNEL |
| 7.2 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| -1.7 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 3.6 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 443.1 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| >2000 | uM | EC3 | Dermal | - | NTP ICE skin sensitization |
| TA269SD04T | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2.28 | ratio | Imax | Dermal | - | NTP ICE skin sensitization |
| 0 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 11.54 | % | Incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 590 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 5900 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP ICE skin sensitization |
| 2557 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP ICE skin sensitization |
| 491.7 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP ICE skin sensitization |
| =1300 | mg/kg bw | LD50 | oral | Rat (Male/Female) | NTP ICE acute oral |
| =1430 | mg/kg bw | LD50 | oral | Rat | NTP ICE acute oral |
| =300 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =300 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =400 | mg/kg bw/day | LEL | oral | Mouse | ToxValDB ToxRefDB |
| =400 | mg/kg bw/day | LEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =6.077e+4 | mg/m3 | LEL | inhalation | Human | ToxValDB DOE Protective Action Criteria |
| =400 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB IRIS |
| >0 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| =200 | mg/kg bw/day | NEL | oral | Mouse | ToxValDB ToxRefDB |
| =200 | mg/kg bw/day | NEL | oral | mouse (b6c3f1; B6C3F1) | EPA ToxRefDB v3 |
| 12 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 300 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 400 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 800 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS DB |
| 1200 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| 1600 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS DB |
| =68.6 | mg/kg bw/day | NOAEL (HED) | oral | Rat | ToxValDB PPRTV (CPHEA) |
| =143 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB IRIS |
| =143 | mg/kg/day | NOEL | oral | - | Regulatory source |
| =200 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB HESS |
| 300 | mg/kg bw/day | POLY-3 lowest dose | Gavage | Mouse | NTP ICE cancer |
| 400 | mg/kg bw/day | POLY-3 lowest dose | Gavage | Mouse | NTP ICE cancer |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP ICE skin sensitization |
| =0.1 | mg/kg bw/day | RfD | oral | Human | ToxValDB IRIS |
Showing 50 of 54 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Benzaldehyde | 202-860-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
BENZALDEHYDE
ChEMBL Phase
-1
Adverse Events
0
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA
1 records
ADI: 0-5 mg/kg bw (1996) mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Benzaldehyde?
Benzaldehyde has 54 NOAEL studies in the database. The lowest reported value is -1.7 % via Dermal. Source: NTP ICE skin sensitization.
What regulatory lists include Benzaldehyde?
Benzaldehyde appears on 30 regulatory/inventory lists including detected; Europe; Vehicle - car interior, air; detected; emissions; Europe; Vehicle - car interior, inert_ingredient; non_food_use; Pesticides, and 27 more. Source: EPA CPDat.
Is Benzaldehyde used in cosmetics?
Yes, Benzaldehyde is also indexed as a cosmetic ingredient under the name BENZALDEHYDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Benzaldehyde come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Benzaldehyde used outside industrial chemicals?
Benzaldehyde also appears in cosmetics, pharmaceutical, food safety, cannabis databases.