Good Cosmetic Ingredient NOAEL Data GHS Classified SCCS/CIR Reviewed Sensitization Data

BENZALDEHYDE

CAS Number
100-52-7
Function
Denaturant, Flavouring, Fragrance, Perfuming
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status Permitted
🇺🇸 US Status permitted
US Notes CIR: S - IJT 25(Suppl. 1):11-27, 2006

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
NOAEL: 200 mg/kg bw/day (oral) – identified as NOAEL for systemic toxicity in rat 90‑day study; used to derive a reference dose of 2 mg/kg/day with 100‑fold uncertainty factor. | Source: RIFM Fragrance Ingredient Safety Assessment for Benzaldehyde, 2019 – uses 200 mg/kg bw/day NOAEL ...

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for BENZALDEHYDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 100 mg/kg bw/day oral rat Chronic COSMOS_DB
NOAEL 1000 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 800 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB
NOAEL 1600 mg/kg bw/day oral mouse Short Term Toxicity COSMOS_DB
NOAEL 1200 mg/kg bw/day oral mouse Subchronic COSMOS_DB
NOAEL 400 mg/kg bw/day oral rat Carcinogenicity COSMOS_DB
NOAEL 300 mg/kg bw/day oral mouse Carcinogenicity COSMOS_DB
NOAEL 800 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 12 mg/kg bw/day oral rat Subchronic COSMOS_DB
NOAEL 500 mg/kg bw/day oral rat Short Term Toxicity COSMOS_DB

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word
WARNING
Pictograms
flam;flame; excl mark;warn
Hazard Statements
Flammable liquid and vapour Harmful if swallowed or in contact with skin Toxic to aquatic life
Short-term Exposure Effects
The substance is irritating to the eyes.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour, through the skin and by ingestion.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: unknown
NOAEL: 400 mg/kg (oral)

Sensitization Profile

Contact sensitization data for BENZALDEHYDE based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.2%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
IFRA Restricted

Source: EU 2023/1545; SCCS/1459/11

Expert Verdict

BENZALDEHYDE is listed in the EU CosIng database with functions: Denaturant, Flavouring, Fragrance, Perfuming It is permitted in the EU without specific restrictions.

⚠️
Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted fragrance needs-enrichment endocrine_disruptor ifra_fragrance fda_food_additive

Frequently Asked Questions

Is BENZALDEHYDE safe in cosmetics?

BENZALDEHYDE is listed in the EU CosIng database with functions: Denaturant, Flavouring, Fragrance, Perfuming It is permitted in the EU without specific restrictions. The EU classifies BENZALDEHYDE as "Permitted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is BENZALDEHYDE allowed in the EU?

BENZALDEHYDE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does BENZALDEHYDE do in cosmetics?

BENZALDEHYDE functions as: Denaturant, Flavouring, Fragrance, Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 100-52-7.

What is the Margin of Safety for BENZALDEHYDE?

NOAEL: 200 mg/kg bw/day (oral) – identified as NOAEL for systemic toxicity in rat 90‑day study; used to derive a reference dose of 2 mg/kg/day with 100‑fold uncertainty factor. | Source: RIFM Fragrance Ingredient Safety Assessment for Benzaldehyde, 2019 – uses 200 mg/kg bw/day NOAEL ... The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for BENZALDEHYDE?

The NOAEL (No Observed Adverse Effect Level) for BENZALDEHYDE is 100 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.

Is BENZALDEHYDE classified as hazardous under GHS?

BENZALDEHYDE carries a GHS signal word of "WARNING". Hazard statements: Flammable liquid and vapour Harmful if swallowed or in contact with skin Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check BENZALDEHYDE compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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