What is the NOAEL for Solketal?
Solketal has 7 NOAEL studies in the database. The lowest reported value is 3XK098O8ZW UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Solketal
Also known as: 5-19-02-00362, Acetone, cyclic (hydroxymethyl)ethylene acetal, Acetone glycerol, BRN 0104465, 2,2-Dimethyl-4-(hydroxymethyl)-1,3-dioxacyclopentane (+7 more)
CAS 100-79-8
Solketal (CAS 100-79-8) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Solketal
CAS Number
100-79-8
DTXSID
DTXSID9021845
Molecular Formula
C6H12O3
InChI Key
RNVYQYLELCKWAN-UHFFFAOYSA-N
Monoisotopic Mass
132.078644
Synonyms
5-19-02-00362Acetone, cyclic (hydroxymethyl)ethylene acetalAcetone glycerolBRN 01044652,2-Dimethyl-4-(hydroxymethyl)-1,3-dioxacyclopentane2,2-Dimethyl-4-oxymethyl-1,3-dioxolaneEINECS 202-888-7Glycerinisopropylidene etherGlycerol, 1,2-O-isopropylidenealpha,beta-Isopropylideneglycerol2,2-Dimethyl-1,3-dioxolan-4-yl methanolUNII-3XK098O8ZW
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
FragranceSolvent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 3XK098O8ZW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3XK098O8ZW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3XK098O8ZW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 3XK098O8ZW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >5000 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2,2-dimethyl-1,3-dioxolan-4-ylmethanol | 202-888-7 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Humectant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3342436
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Solketal?
Solketal appears on 2 regulatory/inventory lists including IFRA Transparency, SCIL (9/2019). Source: EPA CPDat.
Is Solketal used in cosmetics?
Yes, Solketal is also indexed as a cosmetic ingredient under the name Isopropylideneglycerol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Solketal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Solketal used outside industrial chemicals?
Solketal also appears in cosmetics, pharmaceutical databases.