Is Isopropylideneglycerol safe in cosmetics?
Isopropylideneglycerol has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Isopropylideneglycerol
Also known as: 5-19-02-00362, Acetone, cyclic (hydroxymethyl)ethylene acetal, Acetone glycerol, BRN 0104465, 2,2-Dimethyl-4-(hydroxymethyl)-1,3-dioxacyclopentane (+7 more)
INCI: ISOPROPYLIDENEGLYCEROL
Isopropylideneglycerol (CAS 100-79-8) is a cosmetic cosmetic ingredient functioning as Solvent, humectant, skin conditioning agent. Reported NOAEL =300 mg/kg bw/day in Rabbit (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 100-79-8 →
Auto-generated CPSR Part A draft with source citations
Function
Solvent, humectant, skin conditioning agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2,2-dimethyl-1,3-dioxolan-4-yl)methanol
InChIKey
RNVYQYLELCKWAN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted, not listed as prohibited or restricted under 21 CFR 700
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isopropylideneglycerol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Isopropylideneglycerol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rabbit | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
0790
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Solvent
Regulatory List Membership (2)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
Expert Verdict
Expert safety assessment and concern-level summary for Isopropylideneglycerol.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Isopropylideneglycerol by CAS number or substance name.
Studies
2
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
5-19-02-00362
Acetone, cyclic (hydroxymethyl)ethylene acetal
Acetone glycerol
BRN 0104465
2,2-Dimethyl-4-(hydroxymethyl)-1,3-dioxacyclopentane
2,2-Dimethyl-4-oxymethyl-1,3-dioxolane
EINECS 202-888-7
Glycerinisopropylidene ether
Glycerol, 1,2-O-isopropylidene
alpha,beta-Isopropylideneglycerol
2,2-Dimethyl-1,3-dioxolan-4-yl methanol
UNII-3XK098O8ZW
Chemical Function
Fragrance
Solvent
Regulatory Lists
IFRA Transparency
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3342436
Frequently Asked Questions
Is Isopropylideneglycerol allowed in the EU?
Isopropylideneglycerol EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isopropylideneglycerol do in cosmetics?
Isopropylideneglycerol functions as: Solvent, humectant, skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 100-79-8.
What is the NOAEL for Isopropylideneglycerol?
The NOAEL (No Observed Adverse Effect Level) for Isopropylideneglycerol is =300 mg/kg bw/day based on a reproduction developmental study via oral route in Rabbit. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Isopropylideneglycerol used outside cosmetics?
Isopropylideneglycerol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isopropylideneglycerol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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