What is the NOAEL for 1,1-Dimethylphenylethanol?
1,1-Dimethylphenylethanol has 16 NOAEL studies in the database. The lowest reported value is 2.19 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,1-Dimethylphenylethanol
Also known as: 2-Methyl-1-phenylpropan-2-ol, Benzeneethanol, alpha,alpha-dimethyl-, Benzeneethanol, .alpha.,.alpha.-dimethyl-, 4-06-00-03290, Benzyldimethylcarbinol (+15 more)
CAS 100-86-7
1,1-Dimethylphenylethanol (CAS 100-86-7) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Dimethylbenzyl Carbinol (DMBC) →
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noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
26 fields
Name
1,1-Dimethylphenylethanol
CAS Number
100-86-7
DTXSID
DTXSID1047601
Molecular Formula
C10H14O
InChI Key
RIWRBSMFKVOJMN-UHFFFAOYSA-N
Monoisotopic Mass
150.104465
Synonyms
2-Methyl-1-phenylpropan-2-olBenzeneethanol, alpha,alpha-dimethyl-Benzeneethanol, .alpha.,.alpha.-dimethyl-4-06-00-03290Benzyldimethylcarbinol2-Benzyl-2-propanolBenzylpropyl alcoholBRN 1855608alpha,alpha-DimethylbenzeneethanolDimethylbenzylcarbinolalpha,alpha-Dimethylphenethanolalpha,alpha-Dimethylphenethyl alcohol
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
10 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| detected; Toys and children's products | Springer | Published Articles |
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.19 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| N95NCI59MI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N95NCI59MI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N95NCI59MI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| N95NCI59MI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1000 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 1550 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 2592 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =1280 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =50 | mg/kg bw/day | LEL | oral | Chicken | ToxValDB_EFSA |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 500 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
| 4 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-methyl-1-phenylpropan-2-ol | 202-896-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL3183743
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 1,1-Dimethylphenylethanol?
1,1-Dimethylphenylethanol appears on 4 regulatory/inventory lists including detected; Toys and children's products, Europe, IFRA Transparency, and 1 more. Source: EPA CPDat.
Is 1,1-Dimethylphenylethanol used in cosmetics?
Yes, 1,1-Dimethylphenylethanol is also indexed as a cosmetic ingredient under the name Dimethylbenzyl Carbinol (DMBC). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,1-Dimethylphenylethanol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 1,1-Dimethylphenylethanol used outside industrial chemicals?
1,1-Dimethylphenylethanol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.