Is Dimethylbenzyl Carbinol (DMBC) safe in cosmetics?
Dimethylbenzyl Carbinol (DMBC) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Dimethylbenzyl Carbinol (DMBC)
Also known as: 2-Methyl-1-phenylpropan-2-ol, Benzeneethanol, alpha,alpha-dimethyl-, Benzeneethanol, .alpha.,.alpha.-dimethyl-, 4-06-00-03290, Benzyldimethylcarbinol (+15 more)
INCI: DIMETHYL BENZYL CARBINOL
Dimethylbenzyl Carbinol (DMBC) (CAS 100-86-7) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient with warm, herbaceous, floral/lilac character. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 100-86-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient with warm, herbaceous, floral/lilac character
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-methyl-1-phenylpropan-2-ol
InChIKey
RIWRBSMFKVOJMN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS 2393
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dimethylbenzyl Carbinol (DMBC).
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dimethylbenzyl Carbinol (DMBC) across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
1000 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [22] RIFM (1974): RIFM report number 1779, June 6, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2592 | - | - |
| HMT | - | 0 | 5184 | - | - |
| HRIPT | - | 0 | 1550 | - | - |
| HRIPT | - | 0 | 1000 | - | - |
| HMT | - | 0 | 2592 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (6)
JECFA Number
1653
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-BENZYL-2-PROPANOL | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
BENZYL DIMETHYL CARBINOL | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
alpha,alpha-DIMETHYLPHENETHANOL | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-HYDROXY-2-METHYL-1-PHENYLPROPANE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Dimethylbenzyl Carbinol (DMBC).
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
2-Methyl-1-phenylpropan-2-ol
Benzeneethanol, alpha,alpha-dimethyl-
Benzeneethanol, .alpha.,.alpha.-dimethyl-
4-06-00-03290
Benzyldimethylcarbinol
2-Benzyl-2-propanol
Benzylpropyl alcohol
BRN 1855608
alpha,alpha-Dimethylbenzeneethanol
Dimethylbenzylcarbinol
alpha,alpha-Dimethylphenethanol
alpha,alpha-Dimethylphenethyl alcohol
1,1-Dimethyl-2-phenylethanol
DMBC (VAN)
EINECS 202-896-0
FEMA No. 2393
2-Hydroxy-2-methyl-1-phenylpropane
2-Methyl-1-phenyl-2-propanol
NSC 27228
Phenyl-tert-butanol
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
detected; Toys and children's products
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3183743
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ALPHA,ALPHA-DIMETHYLPHENETHYL ALCOHOL
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Dimethylbenzyl Carbinol (DMBC) allowed in the EU?
Dimethylbenzyl Carbinol (DMBC) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dimethylbenzyl Carbinol (DMBC) do in cosmetics?
Dimethylbenzyl Carbinol (DMBC) functions as: Fragrance ingredient with warm, herbaceous, floral/lilac character. It is classified as a cosmetic ingredient in our database. CAS number: 100-86-7.
Is Dimethylbenzyl Carbinol (DMBC) used outside cosmetics?
Dimethylbenzyl Carbinol (DMBC) also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Dimethylbenzyl Carbinol (DMBC) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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