NOAEL Data Cosmetic Ingredient

Manganese(II) sulfate monohydrate

Also known as: Manganese sulfate (MnSO4) monohydrate, Manganese sulfate monohydrate, Manganous sulfate monohydrate, manganese(2+) sulfate monohydrate, Sulfuric acid, manganese(2+) salt, hydrate (1:1:1) (+9 more)

CAS 10034-96-5

Manganese(II) sulfate monohydrate (CAS 10034-96-5) is a chemical substance. Key regulatory status: cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ILO ICSC.

View cosmetic safety profile for Manganese Sulfate →

Cross-Vertical Regulatory Divergence

Manganese(II) sulfate monohydrate is classified GHS Danger (H341, H302, H318, H372, H360, H373, H411) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 20 fields

Name

Manganese(II) sulfate monohydrate

CAS Number

10034-96-5

DTXSID

DTXSID4020795

Molecular Formula

Mn.H2O4S.H2O

InChI Key

ISPYRSDWRDQNSW-UHFFFAOYSA-L

Monoisotopic Mass

170.915988

Synonyms

Manganese sulfate (MnSO4) monohydrateManganese sulfate monohydrateManganous sulfate monohydratemanganese(2+) sulfate monohydrateSulfuric acid, manganese(2+) salt, hydrate (1:1:1)Sulfuric acid, manganese(2+) salt (1:1), monohydrateManganese mesosulfate (MnSO4.H2O)Manganese monosulfate monohydrateSulfuric acid manganese salt (1:1) monohydrateUNII-W00LYS4T26Manganese sulfate hydrateMnSO4.H2O

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Causes serious eye irritation May cause damage to organs through prolonged or repeated exposure Toxic to aquatic life with long lasting effects
Short-term Effects	The substance is irritating to the eyes.
Long-term Effects	The substance may have effects on the central nervous system. Animal tests show that this substance possibly causes toxicity to human reproduction or development.
Routes of Exposure	The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 26 of 26 studies

Value	Unit	Endpoint	Route	Species	Source
W00LYS4T26	UNII	FDA UNII substance identifier	-	-	openFDA substances
W00LYS4T26	UNII	FDA UNII substance identifier	-	-	openFDA substances
W00LYS4T26	UNII	FDA UNII substance identifier	-	-	openFDA substances
W00LYS4T26	UNII	FDA UNII substance identifier	-	-	openFDA substances
=0.01	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
>=0.06	mg/m3	LEL	inhalation	Monkey	ToxValDB_ECHA_IUCLID
<=0.1	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
>=0.3	mg/m3	LEL	inhalation	Monkey	ToxValDB_ECHA_IUCLID
=0.5	mg/m3	LEL	inhalation	Rat	ToxValDB_ECHA_IUCLID
=1.5	mg/m3	LEL	inhalation	Monkey	ToxValDB_ECHA_IUCLID
=72.8	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=83.7	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=200	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=230	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=618.5	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=727.7	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=925	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=1700	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=2000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=4925	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=9850	mg/kg bw/day	NOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
<110	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_HESS
<115	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_HESS
1500	ppm	POLY-3 lowest dose	Dosed feed	Mouse	NTP_ICE_cancer
15000	ppm	POLY-3 lowest dose	Dosed feed	Mouse	NTP_ICE_cancer
15000	ppm	Top dose	Dosed feed	Rat	NTP_ICE_cancer

Showing 26 of 26 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Manganese(II) sulfate monohydrate?

Manganese(II) sulfate monohydrate has 26 NOAEL studies in the database. The lowest reported value is W00LYS4T26 UNII. Source: openFDA substances.

Is Manganese(II) sulfate monohydrate used in cosmetics?

Yes, Manganese(II) sulfate monohydrate is also indexed as a cosmetic ingredient under the name Manganese Sulfate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Manganese(II) sulfate monohydrate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ILO/WHO ICSC, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Manganese(II) sulfate monohydrate have different safety status in cosmetics vs industrial chemicals?

Manganese(II) sulfate monohydrate is classified GHS Danger (H341, H302, H318, H372, H360, H373, H411) in the chemicals database but is allowed in EU cosmetics.

Is Manganese(II) sulfate monohydrate used outside industrial chemicals?

Manganese(II) sulfate monohydrate also appears in cosmetics, cannabis databases.