Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Manganese Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 150 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 20 other | 1992 | rat | inhalation | REACH |
| NOAEL | 20 other | inhalation | - | inhalation | REACH |
| NOAEL | 40 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 150 mg/kg bw/day | dermal | rat | dermal | REACH |
| NOAEL | 40 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 50000 ppm | oral | mouse | oral | REACH |
| NOAEL | 25000 ppm | oral | mouse | oral | REACH |
| NOAEL | 25000 ppm | oral | rat | oral | REACH |
| NOAEL | 3130 ppm | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Permitted in cosmetics but classified as H318 (serious eye damage), H373 (organ damage with repeated exposure), and H411 (aquatic toxicity). Dermal absorption and sensitization data are lacking; neurotoxicity concern exists for aerosolized products.
Regulatory Flags
Frequently Asked Questions
Is Manganese Sulfate safe in cosmetics?
Permitted in cosmetics but classified as H318 (serious eye damage), H373 (organ damage with repeated exposure), and H411 (aquatic toxicity). Dermal absorption and sensitization data are lacking; neurotoxicity concern exists for aerosolized products. The EU classifies Manganese Sulfate as "permitted". Safety rating: MODERATE. 10 toxicological study endpoint(s) are available in our database.
Is Manganese Sulfate allowed in the EU?
Manganese Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Manganese Sulfate do in cosmetics?
Manganese Sulfate functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 10034-96-5.
What is the Margin of Safety for Manganese Sulfate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Manganese Sulfate?
The NOAEL (No Observed Adverse Effect Level) for Manganese Sulfate is 150 mg/kg bw/day based on a dermal study via dermal route in rat. A total of 10 study endpoints are available. Source: REACH.
Is Manganese Sulfate classified as hazardous under GHS?
Manganese Sulfate carries a GHS signal word of "WARNING". Hazard statements: Causes serious eye irritation May cause damage to organs through prolonged or repeated exposure Toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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