Moderate Cosmetic Ingredient NOAEL Data GHS Classified

Manganese Sulfate

Also known as: Manganese sulfate (MnSO4) monohydrate, Manganese sulfate monohydrate, Manganous sulfate monohydrate, manganese(2+) sulfate monohydrate, Sulfuric acid, manganese(2+) salt, hydrate (1:1:1) (+9 more)

INCI: MANGANESE SULFATE

Manganese Sulfate (CAS 10034-96-5) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. NOAEL 40 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.

View industrial chemical safety profile for CAS 10034-96-5 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

Manganese Sulfate is classified GHS Danger (H341, H302, H318, H372, H360, H373, H411) in the chemicals database but is allowed in EU cosmetics.

Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

10034-96-5

View industrial chemical safety profile →

Function

Skin Conditioning

Safety Rating

MODERATE

Chemistry & Identifiers

Formula

H2MnO5S

169.02 g/mol

PubChem CID

177577

IUPAC Name

manganese(2+);sulfate;hydrate

InChIKey

ISPYRSDWRDQNSW-UHFFFAOYSA-L

ChEBI: CHEBI:86364 UNII: W00LYS4T26 Wikidata: Q12447682

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes FDA-approved direct food additive (nutrient/dietary ingredient). No specific restrictions under 21 CFR for cosmetic use.

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Manganese Sulfate.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Manganese Sulfate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	=72.8 mg/kg bw/day	oral	Rat	chronic	ToxValDB_ECHA_IUCLID
NOAEL	=83.7 mg/kg bw/day	oral	Rat	chronic	ToxValDB_ECHA_IUCLID
NOAEL	=200 mg/kg bw/day	oral	Rat	chronic	ToxValDB_ECHA_IUCLID
NOAEL	=230 mg/kg bw/day	oral	Rat	chronic	ToxValDB_ECHA_IUCLID
NOAEL	=618.5 mg/kg bw/day	oral	Rat	subchronic	ToxValDB_ECHA_IUCLID
NOAEL	=727.7 mg/kg bw/day	oral	Rat	subchronic	ToxValDB_ECHA_IUCLID
NOAEL	=925 mg/kg bw/day	oral	Mouse	chronic	ToxValDB_ECHA_IUCLID
NOAEL	=1700 mg/kg bw/day	oral	Rat	subchronic	ToxValDB_ECHA_IUCLID
NOAEL	=2000 mg/kg bw/day	oral	Rat	subchronic	ToxValDB_ECHA_IUCLID
NOAEL	=4925 mg/kg bw/day	oral	Mouse	subchronic	ToxValDB_ECHA_IUCLID

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

WARNING

Pictograms

Excl markWarnCancerHealth hazEnviroAqua

Hazard Statements

Causes serious eye irritation May cause damage to organs through prolonged or repeated exposure Toxic to aquatic life with long lasting effects

Short-term Exposure Effects

The substance is irritating to the eyes.

Long-term Exposure Effects

The substance may have effects on the central nervous system. Animal tests show that this substance possibly causes toxicity to human reproduction or development.

Routes of Exposure

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion.

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Manganese Sulfate across SCCS product categories, with measured dermal absorption where available.

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (2)

Carcinogen Classification

Manganese Sulfate Monohydrate | TR-428: Toxicology and Carcinogenesis Studies of Manganese (II) Sulfate Monohydrate (CASRN 10034-96-5) in F344/N Rats and B6C3F1 Mice (Feed Studies) (1993 ) | 06/23/92 | No Evidence | No Evidence | Equivocal Evidence | Equivocal Evidence | Under the conditions of these 2-year feed studies, there was no evidence of carcinogenic activity of manganese (II) sul

Source: NTP Technical Reports

ICSC Safety Card

0290

Source: ILO-WHO International Chemical Safety Cards (ICSCs)

Expert Verdict

Expert safety assessment and concern-level summary for Manganese Sulfate.

Regulatory Flags

Environmental fda_food_additive

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Manganese Sulfate by CAS number or substance name.

Studies

Lowest NOAEL

72.8 mg/kg bw/day

Highest NOAEL

9850 mg/kg bw/day

ToxValDB_ECHA_IUCLID

Known Synonyms

Manganese sulfate (MnSO4) monohydrate Manganese sulfate monohydrate Manganous sulfate monohydrate manganese(2+) sulfate monohydrate Sulfuric acid, manganese(2+) salt, hydrate (1:1:1) Sulfuric acid, manganese(2+) salt (1:1), monohydrate Manganese mesosulfate (MnSO4.H2O) Manganese monosulfate monohydrate Sulfuric acid manganese salt (1:1) monohydrate UNII-W00LYS4T26 Manganese sulfate hydrate MnSO4.H2O manganese(2+) sulphate monohydrate manganese(II) sulphate monohydrate

Chemical Function

Australian Status

AICIS status: listed

Frequently Asked Questions

Is Manganese Sulfate safe in cosmetics?

Manganese Sulfate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database.

Is Manganese Sulfate allowed in the EU?

Manganese Sulfate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Manganese Sulfate do in cosmetics?

Manganese Sulfate functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 10034-96-5.

What is the NOAEL for Manganese Sulfate?

The NOAEL (No Observed Adverse Effect Level) for Manganese Sulfate is =72.8 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 10 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.

Is Manganese Sulfate classified as hazardous under GHS?

Manganese Sulfate carries a GHS signal word of "WARNING". Hazard statements: Causes serious eye irritation May cause damage to organs through prolonged or repeated exposure Toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Is Manganese Sulfate used outside cosmetics?

Manganese Sulfate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Manganese Sulfate have different safety status in cosmetics vs industrial chemicals?

Manganese Sulfate is classified GHS Danger (H341, H302, H318, H372, H360, H373, H411) in the chemicals database but is allowed in EU cosmetics.

Compliance Tools

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Substance Compliance

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