Also known as: UNII-KL22OLP94K, 2-((4-Methyl-2-nitrophenyl)amino)ethanol, 4-((2-Hydroxyethyl)amino)-3-nitro-1-methylbenzene, 4-(2-Hydroxyethylamino)-3-nitrotoluene, Ethanol, 2-((4-methyl-2-nitrophenyl)amino)- (+1 more)
CAS 100418-33-5
Hydroxyethyl-2-nitro-p-toluidine (CAS 100418-33-5) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H317; H412. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for Hydroxyethyl-2-Nitro-p-Toluidine →
Hydroxyethyl-2-nitro-p-toluidine is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H317, H412).
CAS, identifiers, formula, and alternate names for the matched substance record.
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 3 | H302; H317; H412 | GHS07 | Warning |
Industrial and product-use categories associated with this substance.
Inventory, screening, and regulatory list matches from public chemical databases.
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - hair coloring | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
Toxicology endpoints rendered from public NOAEL study rows.
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 45 | mg/kg bw/day | - | oral | rat | Regulatory source |
| KL22OLP94K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.04 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =0.05 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =45 | mg/kg bw | NOAEL | - | - | SCCS Opinion |
| =45 | mg/kg bw/day | NOAEL | - | rat | SCCS Opinion |
| =45 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =45 | mg/kg bw/d | NOAEL | oral | rat | SCCS Opinion |
| =60 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =90 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =90 | mg/kg bw | NOAEL | - | - | SCCS Opinion |
| =90 | mg/kg bw/day | NOAEL | - | - | SCCS Opinion |
| =240 | mg/kg bw/day | NOAEL | oral | Rat | ECHA |
| =240 | mg/kg bw/day | NOAEL | oral | rat | SCCS Opinion |
| =0.04 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| =0.05 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| 45 | mg/kg bw/day | dermal absorption | - | rat | Regulatory source |
| =45 | mg/kg bw/d | dermal absorption | oral | rat | Regulatory source |
| 45 | mg/kg bw | genotoxicity | - | - | Regulatory source |
| 45 | mg/kg bw/day | genotoxicity | - | - | Regulatory source |
| 45 | mg/kg bw/day | genotoxicity | oral | rat | Regulatory source |
| 90 | mg/kg bw | genotoxicity | - | - | Regulatory source |
| 90 | mg/kg bw/day | genotoxicity | - | - | Regulatory source |
| 240 | mg/kg bw/day | repeated dose toxicity | oral | rat | Regulatory source |
Showing 24 of 24 studies
Registration status from the ECHA REACH registered substances database.
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-((4-methyl-2-nitrophenyl)amino)ethanol | 408-090-7 | ECHA overview → |
Australian industrial chemicals inventory status and applicable conditions.
EU Scientific Committee opinions tied to the matched substance.
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCS/1440/11 | 21 June 2011 | safe | 0.5% | secondary amine; nitrosamine <50ppb; sensitisation not excluded |
| SCCP/0881/05 | 17 March 2006 | safe | 1.0% | secondary amine; nitrosamine <50ppb; sensitisation not excluded |
| SCCP/0924/05 | 2006-03-17 | The SCCP is of the opinion that the information submitted is inadequate to assess the safe use of the substance. | - | Required before further consideration: the stability of Hydroxyethyl-2-nitro-p-toluidine in the various solvents used (e.g. percutaneous absorption study) must be clarified; an in vitro percutaneous absorption study per SCCNFP Notes of Guidance. |
Same-CAS cosmetic ingredient record for cross-vertical context.
Hydroxyethyl-2-nitro-p-toluidine (CAS 100418-33-5) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 3 with signal word Warning. Hazard statements: H302; H317; H412. Source: EU CLP Annex VI (ECHA).
Hydroxyethyl-2-nitro-p-toluidine has 24 NOAEL studies in the database. The lowest reported value is 45 mg/kg bw/day via oral in rat. Source: Regulatory source.
Hydroxyethyl-2-nitro-p-toluidine appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring. Source: EPA CPDat.
Yes, Hydroxyethyl-2-nitro-p-toluidine is also indexed as a cosmetic ingredient under the name Hydroxyethyl-2-Nitro-p-Toluidine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Hydroxyethyl-2-nitro-p-toluidine is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H317, H412).
Hydroxyethyl-2-nitro-p-toluidine also appears in cosmetics databases.