Warning GHS07 NOAEL Data REACH Registered Cosmetic Ingredient

Hydroxyethyl-2-nitro-p-toluidine

Also known as: UNII-KL22OLP94K, 2-((4-Methyl-2-nitrophenyl)amino)ethanol, 4-((2-Hydroxyethyl)amino)-3-nitro-1-methylbenzene, 4-(2-Hydroxyethylamino)-3-nitrotoluene, Ethanol, 2-((4-methyl-2-nitrophenyl)amino)- (+1 more)

CAS 100418-33-5

Hydroxyethyl-2-nitro-p-toluidine (CAS 100418-33-5) is a chemical substance with GHS signal word Warning; key hazard signal: H302; H317; H412. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.

View cosmetic safety profile for Hydroxyethyl-2-Nitro-p-Toluidine →

SOURCE noael studies public
NOAEL studies
60
SOURCE chemical inventory jurisdictions
Regulatory lists
5
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 12 fields
Name
Hydroxyethyl-2-nitro-p-toluidine
CAS Number
100418-33-5
DTXSID
DTXSID20143261
Molecular Formula
C9H12N2O3
InChI Key
SCZQUWZLEIYDBD-UHFFFAOYSA-N
Monoisotopic Mass
196.084792
Synonyms
UNII-KL22OLP94K2-((4-Methyl-2-nitrophenyl)amino)ethanol4-((2-Hydroxyethyl)amino)-3-nitro-1-methylbenzene4-(2-Hydroxyethylamino)-3-nitrotolueneEthanol, 2-((4-methyl-2-nitrophenyl)amino)-3-Nitro-N-(2-Hydroxyethyl)-4-Aminotoluene

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 3H302; H317; H412GHS07Warning

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records
Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records
ListKeywordSource
Europe; Personal care; restrictedEuropean CommissionCosIng
Canada; Personal care; Substances in PCP - Canada (4/2014)Government of CanadaCPCat
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care - hair coloringDanish Environmental Protection AgencyDanish EPA
Europe; Personal care; restrictedEuropean CommissionCosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 60 studies
ValueUnitEndpointRouteSpeciesSource
45mg/kg bw/day-oralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
KL22OLP94KUNIIFDA UNII substance identifier--openFDA substances
KL22OLP94KUNIIFDA UNII substance identifier--openFDA substances
KL22OLP94KUNIIFDA UNII substance identifier--openFDA substances
KL22OLP94KUNIIFDA UNII substance identifier--openFDA substances
=0.04mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.04mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.04mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.04mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.05mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.05mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.05mg/kg bw/dNOAELoralratSCCS_vision_codex
=0.05mg/kg bw/dNOAELoralratSCCS_vision_codex
=45mg/kg bwNOAEL--SCCS_vision_codex
=45mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=45mg/kg bw/dayNOAEL--SCCS_vision_codex
=45mg/kg bw/dNOAELoralratSCCS_vision_codex
=45mg/kg bwNOAEL--SCCS_vision_codex
=45mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=45mg/kg bwNOAEL--SCCS_vision_codex
=45mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=45mg/kg bw/dayNOAEL--SCCS_vision_codex
=45mg/kg bw/dNOAELoralratSCCS_vision_codex
=45mg/kg bw/dayNOAEL--SCCS_vision_codex
=45mg/kg bw/dNOAELoralratSCCS_vision_codex
=45mg/kg bwNOAEL--SCCS_vision_codex
=45mg/kg bw/dayNOAEL-ratSCCS_vision_codex
=45mg/kg bw/dayNOAEL--SCCS_vision_codex
=45mg/kg bw/dNOAELoralratSCCS_vision_codex
=60mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=90mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=90mg/kg bwNOAEL--SCCS_vision_codex
=90mg/kg bw/dayNOAEL--SCCS_vision_codex
=90mg/kg bwNOAEL--SCCS_vision_codex
=90mg/kg bwNOAEL--SCCS_vision_codex
=90mg/kg bw/dayNOAEL--SCCS_vision_codex
=90mg/kg bw/dayNOAEL--SCCS_vision_codex
=90mg/kg bwNOAEL--SCCS_vision_codex
=90mg/kg bw/dayNOAEL--SCCS_vision_codex
=240mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
=240mg/kg bw/dayNOAELoralratSCCS_vision_codex
=240mg/kg bw/dayNOAELoralratSCCS_vision_codex
=240mg/kg bw/dayNOAELoralratSCCS_vision_codex
=240mg/kg bw/dayNOAELoralratSCCS_vision_codex
=240mg/kg bw/dayNOAELoralratSCCS_vision_codex
=240mg/kg bw/dayNOAELoralratSCCS_vision_codex
=240mg/kg bw/dayNOAELoralratSCCS_vision_codex
=240mg/kg bw/dayNOAELoralratSCCS_vision_codex
=0.04mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.05mg/kg bw/ddermal absorptionoralratUnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 60 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-((4-methyl-2-nitrophenyl)amino)ethanol408-090-7ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

SCCS Opinions

EU Scientific Committee opinions tied to the matched substance.

SOURCE EU SCCS 2 opinions
OpinionDateConclusionMax Conc.Concerns
SCCS/1440/1121 June 2011safe0.5%secondary amine; nitrosamine <50ppb; sensitisation not excluded
SCCP/0881/0517 March 2006safe1.0%secondary amine; nitrosamine <50ppb; sensitisation not excluded

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
1.0%
Category
Colorant
View full cosmetic safety profile →

Frequently Asked Questions

What is the GHS hazard classification for Hydroxyethyl-2-nitro-p-toluidine?

Hydroxyethyl-2-nitro-p-toluidine (CAS 100418-33-5) is classified under EU CLP Annex VI as Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 3 with signal word Warning. Hazard statements: H302; H317; H412. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for Hydroxyethyl-2-nitro-p-toluidine?

Hydroxyethyl-2-nitro-p-toluidine has 60 NOAEL studies in the database. The lowest reported value is 45 mg/kg bw/day via oral in rat. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include Hydroxyethyl-2-nitro-p-toluidine?

Hydroxyethyl-2-nitro-p-toluidine appears on 3 regulatory/inventory lists including Europe; Personal care; restricted, Canada; Personal care; Substances in PCP - Canada (4/2014), Europe; Personal care - hair coloring. Source: EPA CPDat.

Is Hydroxyethyl-2-nitro-p-toluidine used in cosmetics?

Yes, Hydroxyethyl-2-nitro-p-toluidine is also indexed as a cosmetic ingredient under the name Hydroxyethyl-2-Nitro-p-Toluidine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Hydroxyethyl-2-nitro-p-toluidine come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does Hydroxyethyl-2-nitro-p-toluidine have different safety status in cosmetics vs industrial chemicals?

Hydroxyethyl-2-nitro-p-toluidine is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H317, H412).

Is Hydroxyethyl-2-nitro-p-toluidine used outside industrial chemicals?

Hydroxyethyl-2-nitro-p-toluidine also appears in cosmetics databases.