Hydroxyethyl-2-Nitro-p-Toluidine

INCI: HYDROXYETHYL-2-NITRO-P-TOLUIDINE

CAS Number
100418-33-5
Function
Direct (non-oxidative) hair dye; also used in oxidative formulations as a non-reactive shade modifier
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
EU Max Conc. 1.0%
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted under coal tar hair dye exemption (21 CFR); caution labeling required

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Secondary amine prone to nitrosation; must not be used with nitrosating agents; possible sensitizing potential not fully excluded; 4-methyl-2-nitroaniline impurity must be controlled below 500 ppm.

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Concern Level: Moderate

Regulatory Flags

potential-allergen eu_cosing_listed

Frequently Asked Questions

Is Hydroxyethyl-2-Nitro-p-Toluidine safe in cosmetics?

Secondary amine prone to nitrosation; must not be used with nitrosating agents; possible sensitizing potential not fully excluded; 4-methyl-2-nitroaniline impurity must be controlled below 500 ppm. The EU classifies Hydroxyethyl-2-Nitro-p-Toluidine as "prohibited". Safety rating: MODERATE.

Is Hydroxyethyl-2-Nitro-p-Toluidine allowed in the EU?

Hydroxyethyl-2-Nitro-p-Toluidine EU regulatory status: prohibited. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxyethyl-2-Nitro-p-Toluidine do in cosmetics?

Hydroxyethyl-2-Nitro-p-Toluidine functions as: Direct (non-oxidative) hair dye; also used in oxidative formulations as a non-reactive shade modifier. It is classified as a cosmetic ingredient in our database. CAS number: 100418-33-5.

What is the Margin of Safety for Hydroxyethyl-2-Nitro-p-Toluidine?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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