Is Hydroxyethyl-2-Nitro-p-Toluidine safe in cosmetics?
Hydroxyethyl-2-Nitro-p-Toluidine has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
Hydroxyethyl-2-Nitro-p-Toluidine
Also known as: UNII-KL22OLP94K, 2-((4-Methyl-2-nitrophenyl)amino)ethanol, 4-((2-Hydroxyethyl)amino)-3-nitro-1-methylbenzene, 4-(2-Hydroxyethylamino)-3-nitrotoluene, Ethanol, 2-((4-methyl-2-nitrophenyl)amino)- (+1 more)
INCI: HYDROXYETHYL-2-NITRO-P-TOLUIDINE
Hydroxyethyl-2-Nitro-p-Toluidine (CAS 100418-33-5) is a cosmetic cosmetic ingredient functioning as Direct (non-oxidative) hair dye; also used in oxidative formulations as a. NOAEL 60 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited, max 1.0%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 100418-33-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Hydroxyethyl-2-Nitro-p-Toluidine is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H317, H412).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Direct (non-oxidative) hair dye; also used in oxidative formulations as a non-reactive shade modifier
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(4-methyl-2-nitroanilino)ethanol
InChIKey
SCZQUWZLEIYDBD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
1.0%
US US Status
permitted
US Notes
Permitted under coal tar hair dye exemption (21 CFR); caution labeling required
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxyethyl-2-Nitro-p-Toluidine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Hydroxyethyl-2-Nitro-p-Toluidine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.04 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.04 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.04 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.04 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.05 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =45 mg/kg bw | - | - | genotoxicity | SCCS_vision_codex |
| NOAEL | =45 mg/kg bw/day | - | rat | dermal absorption | SCCS_vision_codex |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Hydroxyethyl-2-Nitro-p-Toluidine across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *; Skin Sens. 1; Aquatic Chronic 3
Hazard Statements
- H302 Harmful if swallowed
- H317 May cause an allergic skin reaction
- H412 Harmful to aquatic life with long lasting effects
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products. Max: (b) 1,0%.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 1,0%
India: Restricted · max (b) 1.0%
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (5 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.63% | - | - | SCCP/0038 |
| measured | 0.21% | - | - | SCCP/0038 |
| measured | 0.026% | - | - | SCCP/0038 |
| measured | 3.23% | - | - | SCCP/0038 |
| measured | 0.21% | - | - | SCCS/0061 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "100418-33-5", "ingredient_class": "direct_dye", "chemical_class": "nitro", "color_result_on_hair": "Yellow", "shade_range": "blonde", "primary_function": "direct_deposit", "requires_developer": "no", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-10", "light_fastness": "moderate", "oxidation_mechanism": "direct_absorption", "hair_penetration_dep…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Hydroxyethyl-2-Nitro-p-Toluidine.
Regulatory Flags
potential-allergen
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Hydroxyethyl-2-Nitro-p-Toluidine by CAS number or substance name.
Studies
43
Lowest NOAEL
0.04
Highest NOAEL
240
Units vary across source rows: mg/kg bw/day, mg/kg bw, mg/kg bw/d
ToxValDB_ECHA_IUCLID
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.63% | - | - |
| 0.21% | - | - |
| 0.026% | - | - |
| 3.23% | - | - |
| 0.21% | - | - |
Known Synonyms
UNII-KL22OLP94K
2-((4-Methyl-2-nitrophenyl)amino)ethanol
4-((2-Hydroxyethyl)amino)-3-nitro-1-methylbenzene
4-(2-Hydroxyethylamino)-3-nitrotoluene
Ethanol, 2-((4-methyl-2-nitrophenyl)amino)-
3-Nitro-N-(2-Hydroxyethyl)-4-Aminotoluene
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Canada; Personal care; Substances in PCP - Canada (4/2014)
Europe; Personal care - hair coloring
Europe; Personal care - hair coloring
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hydroxyethyl-2-Nitro-p-Toluidine allowed in the EU?
Hydroxyethyl-2-Nitro-p-Toluidine EU regulatory status: prohibited. Maximum allowed concentration: 1.0%. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxyethyl-2-Nitro-p-Toluidine do in cosmetics?
Hydroxyethyl-2-Nitro-p-Toluidine functions as: Direct (non-oxidative) hair dye; also used in oxidative formulations as a non-reactive shade modifier. It is classified as a cosmetic ingredient in our database. CAS number: 100418-33-5.
What is the NOAEL for Hydroxyethyl-2-Nitro-p-Toluidine?
The NOAEL (No Observed Adverse Effect Level) for Hydroxyethyl-2-Nitro-p-Toluidine is =0.04 mg/kg bw/d based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is Hydroxyethyl-2-Nitro-p-Toluidine used outside cosmetics?
Hydroxyethyl-2-Nitro-p-Toluidine also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Hydroxyethyl-2-Nitro-p-Toluidine have different safety status in cosmetics vs industrial chemicals?
Hydroxyethyl-2-Nitro-p-Toluidine is prohibited in EU cosmetics at max 1.0% but has active industrial GHS classifications (H302, H317, H412).
Compliance Tools
Check Hydroxyethyl-2-Nitro-p-Toluidine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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