What is the GHS hazard classification for Calcium chloride?
Calcium chloride (CAS 10043-52-4) is classified under EU CLP Annex VI as Eye Irrit. 2 with signal word Warning. Hazard statements: H319. Source: EU CLP Annex VI (ECHA).
Warning
GHS07
NOAEL Data
REACH Registered
Cosmetic Ingredient
Calcium chloride
Also known as: Calcium chloride (CaCl2), Calcium(2+) chloride, Calcium dichloride, EINECS 233-140-8, Snomelt (+5 more)
CAS 10043-52-4
Calcium chloride (CAS 10043-52-4) is a chemical substance with GHS signal word Warning; key hazard signal: H319. Key regulatory status: REACH registered, 28 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
21
SOURCE
chemical inventory jurisdictions
Regulatory lists
28
SOURCE
eu clp annex vi
GHS signal
Warning
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
16 fields
Name
Calcium chloride
CAS Number
10043-52-4
DTXSID
DTXSID5020235
Molecular Formula
Ca.2ClH
InChI Key
UXVMQQNJUSDDNG-UHFFFAOYSA-L
Monoisotopic Mass
111.915946
Synonyms
Calcium chloride (CaCl2)Calcium(2+) chlorideCalcium dichlorideEINECS 233-140-8SnomeltSuperflake anhydrousUramine MCUNII-OFM21057LPCaCl2[CaCl2]
GHS / CLP Classification
EU harmonized hazard classification, hazard statements, pictograms, and signal word.
SOURCE
EU CLP Annex VI (ECHA)
1 classifications
| Hazard Class | H-Statements | Pictograms | Signal |
|---|---|---|---|
| Eye Irrit. 2 | H319 | GHS07 | Warning |
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | DANGER |
| GHS Hazard Statements | Causes severe skin burns and eye damage May cause respiratory irritation May be harmful if swallowed |
| Short-term Effects | The substance is corrosive to the eyes. The substance is severely irritating to the skin, upper respiratory tract and gastrointestinal tract. |
| Long-term Effects | Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the nasal mucous membrane. This may result in tissue lesions. |
| Routes of Exposure | Serious local effects by all routes of exposure. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Stabilizing agentAstringentViscosity modifierFillerThickening agentProcessing aids not otherwise specifiedChemical reaction regulator
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
28 records
| List | Keyword | Source |
|---|---|---|
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | State of California | State of California |
| active_ingredient; Pesticides | California Department of Pesticide Regulation | State of California |
| active_ingredient; Europe; Pesticides | European Commission | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
| Europe; food_additive; supplements | EU | CPCat |
| active_ingredient; agricultural; Pesticides | USDA | United States Department of Agriculture (USDA) |
| Cleaning products and household care; Europe | Danish Environmental Protection Agency | Danish EPA |
| animal_products | USDA | United States Department of Agriculture (USDA) |
| fracking | FracFocus | FracFocus |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
| fracking; water | NY Department of Conservation | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 21 of 21 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =5 | mg/m3 | DNEL local | inhalation | Human | ToxValDB_GESTIS_DNEL |
| OFM21057LP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OFM21057LP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OFM21057LP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OFM21057LP | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =0.01 | mM | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =2.25 | mM/kg | LOEL | injection | Dog | ToxValDB_ECOTOX |
| =3.4 | mmol/kg | LOEL | oral | Rat | ToxValDB_ECOTOX |
| =4.5 | mM/kg | LOEL | injection | Dog | ToxValDB_ECOTOX |
| =21.5 | mM | LOEL | oral | Rat | ToxValDB_ECOTOX |
| >169 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| >176 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >189 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| >=1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=1560 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=1920 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =1 | mg/kg bw/day | NOEL | injection | Rat | ToxValDB_ECOTOX |
| =2 | % | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =50 | mM | NOEL | oral | Rat | ToxValDB_ECOTOX |
| =80 | mg/kg bw/day | NOEL | oral | Mouse | ToxValDB_ECOTOX |
| =420 | mg/kg bw/day | NOEL | injection | Rat | ToxValDB_ECOTOX |
Showing 21 of 21 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Calcium chloride | 233-140-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Rheology Modifiers
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CALCIUM CHLORIDE
ChEMBL Phase
4
Adverse Events
139
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
2 records
E509 — ADI: NOT LIMITED mg/kg bw | FDA GRAS: FDA has no questions
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What is the NOAEL for Calcium chloride?
Calcium chloride has 21 NOAEL studies in the database. The lowest reported value is 5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
What regulatory lists include Calcium chloride?
Calcium chloride appears on 19 regulatory/inventory lists including drinking_water; Europe; manufacturing; plastic_additive, active_ingredient; Pesticides, active_ingredient; Europe; Pesticides, and 16 more. Source: EPA CPDat.
Is Calcium chloride used in cosmetics?
Yes, Calcium chloride is also indexed as a cosmetic ingredient under the name CALCIUM CHLORIDE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Calcium chloride come from?
Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Calcium chloride used outside industrial chemicals?
Calcium chloride also appears in cosmetics, pharmaceutical, food safety, cannabis databases.