Is CALCIUM CHLORIDE safe in cosmetics?
CALCIUM CHLORIDE has a safety rating of "GOOD" in our database. EU status: permitted.
CALCIUM CHLORIDE
Also known as: Calcium chloride (CaCl2), Calcium(2+) chloride, Calcium dichloride, EINECS 233-140-8, Snomelt (+5 more)
CALCIUM CHLORIDE (CAS 10043-52-4) is a cosmetic cosmetic ingredient functioning as Astringent, Viscosity Controlling. EU Regulation 1223/2009 status: permitted; GHS signal word DANGER. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 10043-52-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
CALCIUM CHLORIDE is classified GHS Danger (H319, H302, H318, H335, H373) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Astringent, Viscosity Controlling
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
calcium dichloride
InChIKey
UXVMQQNJUSDDNG-UHFFFAOYSA-L
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
DANGER
Pictograms
CorrExcl markWarn
Hazard Statements
Causes severe skin burns and eye damage May cause respiratory irritation May be harmful if swallowed
Short-term Exposure Effects
The substance is corrosive to the eyes. The substance is severely irritating to the skin, upper respiratory tract and gastrointestinal tract.
Long-term Exposure Effects
Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the nasal mucous membrane. This may result in tissue lesions.
Routes of Exposure
Serious local effects by all routes of exposure.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LOEL | =1 mg/kg-day | Rat | injection | short-term | ECOTOX |
| NOEL | =1 mg/kg-day | Rat | injection | short-term | ECOTOX |
| NOEL | =80 mg/kg-day | Mouse | oral | short-term | ECOTOX |
| LOEL | =21.5 mM | Rat | oral | short-term | ECOTOX |
| LOEL | =0.01 mM | Rat | oral | short-term | ECOTOX |
| NOEL | <21.5 mM | Rat | oral | short-term | ECOTOX |
| NOEL | <0.01 mM | Rat | oral | short-term | ECOTOX |
| LOEL | =3.4 mmol/kg | Rat | oral | acute | ECOTOX |
| NOEL | =50 mM | Rat | oral | short-term | ECOTOX |
| NOEL | =420 mg/kg-day | Rat | injection | acute | ECOTOX |
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Eye Irrit. 2
Hazard Statements
- H319 Causes serious eye irritation
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Additional Ingredient Properties
4 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "barrier-repair", "mechanism_of_action": "Cofactor for enzymatic reactions, ionic balance", "target_skin_layer": "epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "4-8", "clinical_study_duration_weeks": "8", "sample_size": "20", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Trace element research", "impro…
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "1-7", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low toxicity", "freshwater_toxicity": "can affect salinity", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "no", "palm_oi…
mineral_clay
{"cas_number": "10043-52-4", "ingredient_class": "calcium_compound", "chemical_formula": "CaCl2", "mineral_origin": "synthetic", "particle_size_range_um": "10-500", "surface_area_m2_per_g": "0.5-2", "crystal_structure": "cubic", "color_appearance": "white", "opacity": "opaque", "refractive_index": "1.52", "oil_absorption_g_per_100g": "100-300", "water_absorption_capacity": "low", "surface_charge_a…
ph_stability
{"optimal_ph_min": "5.0", "optimal_ph_max": "9.0", "stable_ph_min": "4.5", "stable_ph_max": "10.0", "degrades_above_ph": "11.0", "degrades_below_ph": "4.0", "ph_dependent_function": "Mineral supplement", "formulation_note": "Relatively stable", "source": "Formulation literature"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1184
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Inhalation: Causes irritation of nose and throat. | Contact with eyes, particularly by dust, causes irritation and possible transient corneal injury. | Contact of solid with dry skin causes mild irritation; strong solutions cause marked irritation or burns.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Evaluation
CALCIUM CHLORIDE | 1973 | NOT LIMITED | NMRS 53/TRS 539-JECFA 17/37 | FAS 5/NMRS 53A-JECFA 17/415
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-caking agent
Astringent
Biocide
Chemical reaction regulator
Drier
Filler
Flavouring and nutrient
Heat transferring agent
Humectant
Processing aids not otherwise specified
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for CALCIUM CHLORIDE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
epa_safer_alternative
fda_food_additive
jecfa_safe
Known Synonyms
Calcium chloride (CaCl2)
Calcium(2+) chloride
Calcium dichloride
EINECS 233-140-8
Snomelt
Superflake anhydrous
Uramine MC
UNII-OFM21057LP
CaCl2
[CaCl2]
Chemical Function
Stabilizing agent
Regulatory Lists
drinking_water; Europe; manufacturing; plastic_additive
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Europe; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Europe; food_additive; supplements
active_ingredient; agricultural; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CALCIUM CHLORIDE
ChEMBL ID
CHEMBL1200668
Max Phase
4
Adverse Event Associations
139
Frequently Asked Questions
Is CALCIUM CHLORIDE allowed in the EU?
CALCIUM CHLORIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CALCIUM CHLORIDE do in cosmetics?
CALCIUM CHLORIDE functions as: Astringent, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 10043-52-4.
Is CALCIUM CHLORIDE classified as hazardous under GHS?
CALCIUM CHLORIDE carries a GHS signal word of "DANGER". Hazard statements: Causes severe skin burns and eye damage May cause respiratory irritation May be harmful if swallowed. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is CALCIUM CHLORIDE used outside cosmetics?
CALCIUM CHLORIDE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does CALCIUM CHLORIDE have different safety status in cosmetics vs industrial chemicals?
CALCIUM CHLORIDE is classified GHS Danger (H319, H302, H318, H335, H373) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check CALCIUM CHLORIDE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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