Good Cosmetic Ingredient NOAEL Data GHS Classified

CALCIUM CHLORIDE

CAS Number

10043-52-4

Function

Astringent, Viscosity Controlling

Safety Rating

GOOD

Regulatory Status

🇪🇺 EU Status Permitted

🇺🇸 US Status Not specifically regulated

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Toxicological Studies

4 study endpoints found for CALCIUM CHLORIDE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	>=20000 ppm	oral	rat	oral	REACH
NOAEL	>=20000 ppm	oral	rat	oral	REACH
NOAEL	>=20000 ppm	oral	rat	oral	REACH
NOAEL	>=20000 ppm	oral	rat	oral	REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Signal Word

DANGER

Pictograms

corr; excl mark;warn

Hazard Statements

Causes severe skin burns and eye damage May cause respiratory irritation May be harmful if swallowed

Short-term Exposure Effects

The substance is corrosive to the eyes. The substance is severely irritating to the skin, upper respiratory tract and gastrointestinal tract.

Long-term Exposure Effects

Repeated or prolonged contact with skin may cause dermatitis. The substance may have effects on the nasal mucous membrane. This may result in tissue lesions.

Routes of Exposure

Serious local effects by all routes of exposure.

Expert Verdict

CALCIUM CHLORIDE is listed in the EU CosIng database with functions: Astringent, Viscosity Controlling It is permitted in the EU without specific restrictions.

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Concern Level: Low

Regulatory Flags

cosing-sourced eu-permitted needs-enrichment epa_safer_alternative fda_food_additive jecfa_safe

Frequently Asked Questions

Is CALCIUM CHLORIDE safe in cosmetics?

CALCIUM CHLORIDE is listed in the EU CosIng database with functions: Astringent, Viscosity Controlling It is permitted in the EU without specific restrictions. The EU classifies CALCIUM CHLORIDE as "Permitted". Safety rating: GOOD. 4 toxicological study endpoint(s) are available in our database.

Is CALCIUM CHLORIDE allowed in the EU?

CALCIUM CHLORIDE EU regulatory status: Permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CALCIUM CHLORIDE do in cosmetics?

CALCIUM CHLORIDE functions as: Astringent, Viscosity Controlling. It is classified as a cosmetic ingredient in our database. CAS number: 10043-52-4.

What is the NOAEL for CALCIUM CHLORIDE?

The NOAEL (No Observed Adverse Effect Level) for CALCIUM CHLORIDE is >=20000 ppm based on a oral study via oral route in rat. A total of 4 study endpoints are available. Source: REACH.

Is CALCIUM CHLORIDE classified as hazardous under GHS?

CALCIUM CHLORIDE carries a GHS signal word of "DANGER". Hazard statements: Causes severe skin burns and eye damage May cause respiratory irritation May be harmful if swallowed. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.

Compliance Tools

Check CALCIUM CHLORIDE compliance across multiple jurisdictions:

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82 Allergen Checker

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Substance Compliance

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MoS Calculator

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Heavy Metal Limits

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