What is the NOAEL for Triclocarban?
Triclocarban has 100 NOAEL studies in the database. The lowest reported value is 0.0006 mg/kg bw/day via oral. Source: Regulatory source.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Triclocarban
Also known as: Urea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-, 4-12-00-01265, BRN 2814890, Caswell No. 874, 1-(3',4'-Dichlorophenyl)-3-(4'-chlorophenyl)urea (+9 more)
CAS 101-20-2
Triclocarban (CAS 101-20-2) is a chemical substance. Key regulatory status: REACH registered, 13 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
SOURCE
NOAEL studies
NOAEL studies
100
SOURCE
Chemical inventory jurisdictions
Regulatory lists
13
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
20 fields
Name
Triclocarban
CAS Number
101-20-2
DTXSID
DTXSID4026214
Molecular Formula
C13H9Cl3N2O
InChI Key
ICUTUKXCWQYESQ-UHFFFAOYSA-N
Monoisotopic Mass
313.978046
Synonyms
Urea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-4-12-00-01265BRN 2814890Caswell No. 8741-(3',4'-Dichlorophenyl)-3-(4'-chlorophenyl)ureaEINECS 202-924-1EPA Pesticide Chemical Code 027901NSC-72005TrichlocarbanTrilocarbanTriclocarbanumUNII-BGG1Y1ED0Y
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
BiocidePreservativeDeodorizer
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
13 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care; restricted | European Commission | CosIng |
| Europe; Personal care | European Commission | CosIng |
| pharmaceutical | US International Trade Commission | CPCat |
| active_ingredient; Europe; Pesticides | Commission of the European Communities | CPCat |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; wastewater | Minnesota Pollution Control Agency | State of Minnesota |
| detected; MN Chemical Screening; surface_water | Minnesota Pollution Control Agency | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| detected; drinking_water; MN Chemical Screening | EPA & USGS | State of Minnesota |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.0006 | - | - | oral | - | Regulatory source |
| 0.0321 | mg/kg bw/d | - | oral | - | Regulatory source |
| =0.2 | % | - | - | - | Regulatory source |
| 0.5 | - | - | - | - | Regulatory source |
| 1 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 1.5 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 2 | - | - | dermal | - | Regulatory source |
| =3 | mg/kg bw/day | - | - | mouse | Regulatory source |
| 5 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 5 | mg/kg bw/day | - | oral | rat | Regulatory source |
| =6.75 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 6.75 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 8 | mg/kg | - | oral | rat | Regulatory source |
| =8 | mg/kg bw/day | - | oral | rat | Regulatory source |
| =8 | mg/kg bw/day | - | - | rat | Regulatory source |
| =8 | mg/kg bw/day | - | oral | rat | Regulatory source |
| 8 | mg/kg bw/day | - | oral | - | Regulatory source |
| 8 | mg/kg bw/d | - | oral | rat | Regulatory source |
| 8 | mg/kg | - | - | rat | Regulatory source |
| 8 | mg/kg | - | - | rat | Regulatory source |
| 8 | mg/kg | - | - | rat | Regulatory source |
| 8 | - | - | - | human | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | oral | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
| 8 | - | - | - | - | Regulatory source |
Showing 50 of 100 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Triclocarban | 202-924-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
SCCS Opinion
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/0851/04 | 21 June 2005 | Safe with restrictions — safe in rinse-off hand/body care products at 1.5% for non-preservative antimicrobial use | 1.5% in rinse-off hand/body care products | Low acute and chronic toxicity; potential endocrine activity (anti-androgenic); assessed as non-preservative antimicrobial use |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
1.5%
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
ChEMBL / DailyMed
TRICLOCARBAN
ChEMBL Phase
2
Adverse Events
0
Bioactivity
7
Frequently Asked Questions
What regulatory lists include Triclocarban?
Triclocarban appears on 9 regulatory/inventory lists including Europe; Personal care; restricted, Europe; Personal care, pharmaceutical, and 6 more. Source: EPA CPDat.
Is Triclocarban used in cosmetics?
Yes, Triclocarban is also indexed as a cosmetic ingredient under the name Triclocarban. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Triclocarban come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Triclocarban used outside industrial chemicals?
Triclocarban also appears in cosmetics, pharmaceutical databases.