Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Triclocarban. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 25 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >1000 other | oral | rat | oral | REACH |
| NOAEL | 75 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 250 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 100 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 2500 mg/kg bw/day | oral | rat | oral | REACH |
| NOEL | =25 mg/kg/day | oral | rat | chronic | SCCS |
| NOAEL | =95 mg/kg/day | oral | rat | reproductive | SCCS |
| NOAEL | =280 mg/kg/day | oral | rat | reproductive | SCCS |
SCCS NOAEL Values
NOAEL/LOAEL values cited in official SCCS opinions for Triclocarban.
| NOAEL | LOAEL | Route | Species | Study | DA% (SCCS) | Opinion |
|---|---|---|---|---|---|---|
| 5 mg/kg/day | 25 mg/kg/day | Oral | Rat | Subchronic (90-day) (90 days) | 100 | SCCS/1643/22 (2022) |
Expert Verdict
Triclocarban is a preservative and antimicrobial agent with restricted use in the EU at maximum 1.5% concentration and permitted status in the US.
Regulatory Flags
Frequently Asked Questions
Is Triclocarban safe in cosmetics?
Triclocarban is a preservative and antimicrobial agent with restricted use in the EU at maximum 1.5% concentration and permitted status in the US. The EU classifies Triclocarban as "restricted". Safety rating: GOOD. 10 toxicological study endpoint(s) are available in our database.
Is Triclocarban allowed in the EU?
Triclocarban EU regulatory status: restricted. Maximum allowed concentration: 1.5%. This is based on EU Regulation 1223/2009 and its amendments.
What does Triclocarban do in cosmetics?
Triclocarban functions as: Preservative. It is classified as a Preservative in our database. CAS number: 101-20-2.
What is the Margin of Safety for Triclocarban?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Triclocarban?
The NOAEL (No Observed Adverse Effect Level) for Triclocarban is 25 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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