What is the NOAEL for Phenylacetaldehyde dimethyl acetal?
Phenylacetaldehyde dimethyl acetal has 13 NOAEL studies in the database. The lowest reported value is 0.2857 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Phenylacetaldehyde dimethyl acetal
Also known as: Phenyl acetaldehyde dimethyl acetal, Benzene, (2,2-dimethoxyethyl)-, (2,2-Dimethoxyethyl)benzene, 4-07-00-00664, BRN 0879360 (+14 more)
CAS 101-48-4
Phenylacetaldehyde dimethyl acetal (CAS 101-48-4) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Phenylacetaldehyde Dimethyl Acetal →
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noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
25 fields
Name
Phenylacetaldehyde dimethyl acetal
CAS Number
101-48-4
DTXSID
DTXSID3047001
Molecular Formula
C10H14O2
InChI Key
WNJSKZBEWNVKGU-UHFFFAOYSA-N
Monoisotopic Mass
166.09938
Synonyms
Phenyl acetaldehyde dimethyl acetalBenzene, (2,2-dimethoxyethyl)-(2,2-Dimethoxyethyl)benzene4-07-00-00664BRN 08793602,2-Dimethoxy-1-phenylethaneEINECS 202-945-6Ethane, 1,1-dimethoxy-2-phenyl-FEMA No. 2876Hyscylene PNSC 5174Phenacetaldehyde dimethyl acetal
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
22 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| Europe | European Commission | Fl@vis |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 0.3571 | % | Concentration, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 0.2857 | % | Concentration, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| P8C94L4MUR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8C94L4MUR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8C94L4MUR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P8C94L4MUR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 28 | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 231.4 | ug/cm2 | Induction dose per skin area, 5% incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 185.1 | ug/cm2 | Induction dose per skin area, one positive response | Dermal | Human | NTP_ICE_skin_sensitization |
| >=600 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,1-dimethoxy-2-phenylethane | 202-945-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL3185401
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Phenylacetaldehyde dimethyl acetal?
Phenylacetaldehyde dimethyl acetal appears on 4 regulatory/inventory lists including Europe, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Phenylacetaldehyde dimethyl acetal used in cosmetics?
Yes, Phenylacetaldehyde dimethyl acetal is also indexed as a cosmetic ingredient under the name Phenylacetaldehyde Dimethyl Acetal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Phenylacetaldehyde dimethyl acetal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Phenylacetaldehyde dimethyl acetal used outside industrial chemicals?
Phenylacetaldehyde dimethyl acetal also appears in cosmetics, pharmaceutical, food safety, cannabis databases.