Excellent Cosmetic Ingredient NOAEL Data

Phenylacetaldehyde Dimethyl Acetal

INCI: PHENYLACETALDEHYDE DIMETHYL ACETAL

CAS Number
101-48-4
Function
Fragrance
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA GRAS as flavoring (21 CFR 172.515 for parent aldehyde); not restricted in cosmetics; IFRA compliant

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

1 study endpoint found for Phenylacetaldehyde Dimethyl Acetal. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL >=600 mg/kg bw/day oral rat oral REACH

Expert Verdict

Not genotoxic; not phototoxic/photoallergenic; not PBT. Hydrolysis product phenylacetaldehyde requires EU allergen declaration.

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Concern Level: Low

Regulatory Flags

potential-allergen fragrance-component ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Phenylacetaldehyde Dimethyl Acetal safe in cosmetics?

Not genotoxic; not phototoxic/photoallergenic; not PBT. Hydrolysis product phenylacetaldehyde requires EU allergen declaration. The EU classifies Phenylacetaldehyde Dimethyl Acetal as "permitted". Safety rating: EXCELLENT. 1 toxicological study endpoint(s) are available in our database.

Is Phenylacetaldehyde Dimethyl Acetal allowed in the EU?

Phenylacetaldehyde Dimethyl Acetal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Phenylacetaldehyde Dimethyl Acetal do in cosmetics?

Phenylacetaldehyde Dimethyl Acetal functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 101-48-4.

What is the Margin of Safety for Phenylacetaldehyde Dimethyl Acetal?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Phenylacetaldehyde Dimethyl Acetal?

The NOAEL (No Observed Adverse Effect Level) for Phenylacetaldehyde Dimethyl Acetal is >=600 mg/kg bw/day based on a oral study via oral route in rat. Source: REACH.

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