Is Phenylacetaldehyde Dimethyl Acetal safe in cosmetics?
Phenylacetaldehyde Dimethyl Acetal has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Phenylacetaldehyde Dimethyl Acetal
Also known as: Phenyl acetaldehyde dimethyl acetal, Benzene, (2,2-dimethoxyethyl)-, (2,2-Dimethoxyethyl)benzene, 4-07-00-00664, BRN 0879360 (+14 more)
INCI: PHENYLACETALDEHYDE DIMETHYL ACETAL
Phenylacetaldehyde Dimethyl Acetal (CAS 101-48-4) is a cosmetic cosmetic ingredient functioning as Fragrance. NOAEL 600 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 101-48-4 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2,2-dimethoxyethylbenzene
InChIKey
WNJSKZBEWNVKGU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA GRAS as flavoring (21 CFR 172.515 for parent aldehyde); not restricted in cosmetics; IFRA compliant
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenylacetaldehyde Dimethyl Acetal.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Phenylacetaldehyde Dimethyl Acetal across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
1296 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [34] Kligman AM (1971): Reports to RIFM, 20 April and 9 June, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1296 | - | - |
| HMT | - | 0 | 1296 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1003
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
VIRIDINE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PHENYLACETALDEHYDE DIMETHYL ACETAL | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/53 | FAS 50-JECFA 59/215
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Phenylacetaldehyde Dimethyl Acetal.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Phenyl acetaldehyde dimethyl acetal
Benzene, (2,2-dimethoxyethyl)-
(2,2-Dimethoxyethyl)benzene
4-07-00-00664
BRN 0879360
2,2-Dimethoxy-1-phenylethane
EINECS 202-945-6
Ethane, 1,1-dimethoxy-2-phenyl-
FEMA No. 2876
Hyscylene P
NSC 5174
Phenacetaldehyde dimethyl acetal
2-Phenylacetaldehyde dimethyl acetal
Phenylacetic aldehyde dimethyl acetal
alpha-Tolyl aldehyde dimethyl acetal
alpha-Tolylaldehyde dimethyl acetal
Viridine
UNII-P8C94L4MUR
1,1-Dimethoxy-2-phenylethane
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185401
Frequently Asked Questions
Is Phenylacetaldehyde Dimethyl Acetal allowed in the EU?
Phenylacetaldehyde Dimethyl Acetal EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenylacetaldehyde Dimethyl Acetal do in cosmetics?
Phenylacetaldehyde Dimethyl Acetal functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 101-48-4.
Is Phenylacetaldehyde Dimethyl Acetal used outside cosmetics?
Phenylacetaldehyde Dimethyl Acetal also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenylacetaldehyde Dimethyl Acetal compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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