NOAEL Data REACH Registered Cosmetic Ingredient

Diphenyl oxide

Also known as: Benzene, 1,1'-oxybis-, Phenyl ether, Phenoxybenzene, 4-06-00-00568, BRN 1364620 (+15 more)

CAS 101-84-8

Diphenyl oxide (CAS 101-84-8) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC, OSHA.

View cosmetic safety profile for Diphenyl Ether →

Cross-Vertical Regulatory Divergence

Diphenyl oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H319, H400, H410, H411, H360Df, H303, H316, H320).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Diphenyl oxide

CAS Number

101-84-8

DTXSID

DTXSID9021847

Molecular Formula

C12H10O

InChI Key

USIUVYZYUHIAEV-UHFFFAOYSA-N

Monoisotopic Mass

170.073165

Synonyms

Benzene, 1,1'-oxybis-Phenyl etherPhenoxybenzene4-06-00-00568BRN 1364620EINECS 202-981-2Ether, diphenyl-FEMA No. 3667UNII-3O695R5M1U1,1'-Oxybis-Benzene1,1'-Oxybisbenzene, 9CI1,1'-Oxydibenzene

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	May be harmful if swallowed Causes mild skin irritation Causes eye irritation Very toxic to aquatic life with long lasting effects
Short-term Effects	The substance is mildly irritating to the eyes, skin and upper respiratory tract.
Long-term Effects	Repeated or prolonged contact with skin may cause dermatitis.

OSHA Exposure Limits

Occupational exposure limits from OSHA, NIOSH, and ACGIH rows.

SOURCE OSHA / NIOSH / ACGIH occupational exposure limits 6 records

Agency	Metric	Value	ppm	mg/m3	Skin
OSHA	TWA	1 ppm (7 mg/m³)	1	7	N
NIOSH	TWA	1 ppm (7 mg/m³)	1	7	N
ACGIH	TWA	1 ppm [1979]	1	-	N
ACGIH	STEL	2 ppm [1979]	2	-	N
CAL/OSHA	TWA	1 ppm (7 mg/m³)	1	7	N
NIOSH	IDLH	100 ppm	100	-	-

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 60 records

FragranceDeodorizerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 5 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
Europe	European Commission	Fl@vis
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
SCIL (9/2019)	USEPA	Safer Chemical Ingredients List
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 29 of 29 studies

Value	Unit	Endpoint	Route	Species	Source
=7	mg/m3	DNEL local	inhalation	Human	ToxValDB_GESTIS_DNEL
=59	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
3O695R5M1U	UNII	FDA UNII substance identifier	-	-	openFDA substances
3O695R5M1U	UNII	FDA UNII substance identifier	-	-	openFDA substances
3O695R5M1U	UNII	FDA UNII substance identifier	-	-	openFDA substances
3O695R5M1U	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
2592	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
=2450	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>2490	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=2830	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
<3210	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=3990	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=48731.4	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=15	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_EFSA
=15	mg/kg bw/day	NOAEL	oral: unspecified	Rat	EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
=35	mg/m3	NOAEL	inhalation	Rat	ToxValDB_EU_SCOEL
>=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HPVIS
>480	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HPVIS
=500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
540	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=1000	mg/kg bw/day	NOAEL	dermal	Rat	ToxValDB_ECHA_IUCLID
=100	mg/kg bw/day	NOEL	dermal	Rat	ToxValDB_ECHA_IUCLID
=301	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
=335	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization
=0.0004	mg/m3	RfC	inhalation	Human	ToxValDB_RSL
=0.004	mg/m3	RfC	inhalation	Human	ToxValDB_RSL

Showing 29 of 29 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Diphenyl ether	202-981-2	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL DIPHENYLETHER

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Food Safety Data

Same-CAS food additive, ADI, and GRAS records where available.

SOURCE EFSA / FDA GRAS 1 records

ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw

View full food safety profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Diphenyl oxide?

Diphenyl oxide has 29 NOAEL studies in the database. The lowest reported value is 7 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.

What regulatory lists include Diphenyl oxide?

Diphenyl oxide appears on 5 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.

What are the occupational exposure limits for Diphenyl oxide?

Occupational exposure limits for Diphenyl oxide are set by OSHA, NIOSH, ACGIH. 6 limit values from official agencies are documented in the database. Source: OSHA, NIOSH, ACGIH.

Is Diphenyl oxide used in cosmetics?

Yes, Diphenyl oxide is also indexed as a cosmetic ingredient under the name Diphenyl Ether. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Diphenyl oxide come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, OSHA/NIOSH/ACGIH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Diphenyl oxide have different safety status in cosmetics vs industrial chemicals?

Diphenyl oxide is prohibited in EU cosmetics but has active industrial GHS classifications (H319, H400, H410, H411, H360Df, H303, H316, H320).

Is Diphenyl oxide used outside industrial chemicals?

Diphenyl oxide also appears in cosmetics, pharmaceutical, food safety, cannabis databases.