Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Diphenyl Ether. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 540 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Skin and eye irritant with environmental persistence concerns including water contamination; RIFM safety assessment should be referenced for fragrance use.
Regulatory Flags
Frequently Asked Questions
Is Diphenyl Ether safe in cosmetics?
Skin and eye irritant with environmental persistence concerns including water contamination; RIFM safety assessment should be referenced for fragrance use. The EU classifies Diphenyl Ether as "prohibited". Safety rating: MODERATE. 1 toxicological study endpoint(s) are available in our database.
Is Diphenyl Ether allowed in the EU?
Diphenyl Ether EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diphenyl Ether do in cosmetics?
Diphenyl Ether functions as: Masking agent / perfuming agent. It is classified as a cosmetic ingredient in our database. CAS number: 101-84-8.
What is the Margin of Safety for Diphenyl Ether?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diphenyl Ether?
The NOAEL (No Observed Adverse Effect Level) for Diphenyl Ether is 540 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. Source: COSMOS_DB.
Is Diphenyl Ether classified as hazardous under GHS?
Diphenyl Ether carries a GHS signal word of "WARNING". Hazard statements: May be harmful if swallowed Causes mild skin irritation Causes eye irritation Very toxic to aquatic life with long lasting effects. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
Check Diphenyl Ether compliance across multiple jurisdictions:
Related Ingredients
Is Diphenyl Ether in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Diphenyl Ether in your formulation.