What is the NOAEL for 2-(Phenylmethylene)octanal?
2-(Phenylmethylene)octanal has 100 NOAEL studies in the database. The lowest reported value is -1.6 % via Dermal. Source: NTP ICE skin sensitization.
NOAEL Data
Cosmetic Ingredient
2-(Phenylmethylene)octanal
Also known as: Hexyl cinnamic aldehyde (Octanal, 2-(phenylmethylene)-) (.alpha.-Hexylcinnamaldehyde), Hexyl cinnamic aldehyde, Octanal, 2-(phenylmethylene)-, alpha-Hexylcinnamaldehyde, Cinnamaldehyde, alpha-hexyl- (+12 more)
CAS 101-86-0
2-(Phenylmethylene)octanal (CAS 101-86-0) is a chemical substance. Key regulatory status: 38 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
SOURCE
NOAEL studies
NOAEL studies
100
SOURCE
Chemical inventory jurisdictions
Regulatory lists
38
SOURCE
EU CLP Annex VI
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
2-(Phenylmethylene)octanal
CAS Number
101-86-0
DTXSID
DTXSID4026684
Molecular Formula
C15H20O
InChI Key
GUUHFMWKWLOQMM-UHFFFAOYSA-N
Monoisotopic Mass
216.151415
Synonyms
Hexyl cinnamic aldehyde (Octanal, 2-(phenylmethylene)-) (.alpha.-Hexylcinnamaldehyde)Hexyl cinnamic aldehydeOctanal, 2-(phenylmethylene)-alpha-HexylcinnamaldehydeCinnamaldehyde, alpha-hexyl-EINECS 202-983-3FEMA No. 25692-Benzylideneoctanal2-Hexylcinnamaldehydealpha-Hexylcinnamic aldehydealpha-Hexylcinnamyl aldehydealpha-Hexyl-beta-phenylacrolein
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Fragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
38 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - air freshener; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| air; Cleaning products and household care - air freshener; detected; emissions; Europe | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - body hygiene - hand soap | Danish Environmental Protection Agency | Danish EPA |
| Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - general moisturizing - hand/body lotion | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; detected; Europe; Personal care - body hygiene - body wash; Personal care - general moisturizing - hand/body lotion; Personal care - specialized bath products - bubble bath | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - deodorant | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care - dishwasher and dishes - automatic dishwashing detergent; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care; Europe | Danish EPA | Danish EPA |
| Cleaning products and household care - air freshener; Cleaning products and household care - laundry and fabric treatment - fabric deodorizer; detected; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry stain remover; detected; Europe | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 100 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 64.160245738986 | uM | AC50 | - | - | NTP ICE endocrine |
| 68.0968267916156 | uM | ACC | - | - | NTP ICE endocrine |
| 21 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 25.7 | ug/mL | CD54, EC200 | Dermal | - | NTP ICE skin sensitization |
| 4.86 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 6.3 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 20.3 | ug/mL | CD86, EC150 | Dermal | - | NTP ICE skin sensitization |
| 22.22 | ug/mL | CV70 | Dermal | - | NTP ICE skin sensitization |
| 19 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 21.7 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 22.9 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 35 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 36.5 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 37 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 39.4 | ug/mL | CV75 | Dermal | - | NTP ICE skin sensitization |
| 14.36 | uL/min/10^6 cells | Clint | - | Human | NTP ICE adme parameters |
| -0.3 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| -0.2 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| 12.3 | % | Depletion Cys | Dermal | - | NTP ICE skin sensitization |
| -1.6 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| -0.9 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| 0.5 | % | Depletion Lys | Dermal | - | NTP ICE skin sensitization |
| - | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 0.3 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 5.7 | % | Depletion Lys + Cys | Dermal | - | NTP ICE skin sensitization |
| 13.23 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 14.53 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 15.18 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 16.2 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 17.2 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 17.27 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 17.75 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 18.3 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 19.4 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 22 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 23 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 23.22 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 23.5 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 25.19 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 31.33 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| >2000 | uM | EC1.5 | Dermal | - | NTP ICE skin sensitization |
| 1.2 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 1.2 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 1.2 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 1.2 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 2.7 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 2.7 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 2.7 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 2.7 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
| 4.4 | % | EC3 | Dermal | Mouse | NTP ICE skin sensitization |
Showing 50 of 100 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
Mandatory labeling in leave-on products at >0.001%; rinse-off >0.01%
Category
fragrance
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
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Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-(Phenylmethylene)octanal?
2-(Phenylmethylene)octanal appears on 27 regulatory/inventory lists including air; detected; emissions; Europe; Vehicle - car interior, detected; Europe; Vehicle - car interior, Europe, and 24 more. Source: EPA CPDat.
Is 2-(Phenylmethylene)octanal used in cosmetics?
Yes, 2-(Phenylmethylene)octanal is also indexed as a cosmetic ingredient under the name Hexyl Cinnamal. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-(Phenylmethylene)octanal come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-(Phenylmethylene)octanal used outside industrial chemicals?
2-(Phenylmethylene)octanal also appears in cosmetics, food safety, cannabis databases.