Moderate Fragrance Sensitization Data Dermal Penetration

Hexyl Cinnamal

INCI: HEXYL CINNAMAL

CAS Number
101-86-0
Function
Skin Conditioning
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status restricted
EU Max Conc. Mandatory labeling in leave-on products at >0.001%; rinse-off >0.01%
🇺🇸 US Status permitted
US Notes IFRA restricts by product category; high-volume fragrance ingredient; widely used in consumer products

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Hexyl Cinnamal based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.5%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted

Source: ESSCA/IVDK

Dermal Penetration Profile

Skin absorption and penetration characteristics of Hexyl Cinnamal, relevant to systemic exposure and MoS calculations.

Absorption %
15-25%
Penetration Level
epidermis
Penetration Depth
epidermis
Molecular Weight
202.3 Da
Log P
4.8
Systemic Absorption
yes
Topical Bioavailability
10-20%
Safety Margin Factor
high
Vehicle Dependent
Yes — absorption varies by formulation

Source: SCCS/1459/11, IFRA

Expert Verdict

FM II fragrance allergen and one of the highest-volume synthetic fragrance ingredients in global use. EU Annex III listed with mandatory labeling requirements. Confirmed sensitizer; IFRA restricts use by product category per QRA2 risk assessment framework.

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Concern Level: Moderate

Regulatory Flags

fragrance-allergen eu-annex-iii fm-ii patch-test-standard mandatory-label high-volume eu_children_restricted ifra_fragrance fda_food_additive eu_cosing_listed

Frequently Asked Questions

Is Hexyl Cinnamal safe in cosmetics?

FM II fragrance allergen and one of the highest-volume synthetic fragrance ingredients in global use. EU Annex III listed with mandatory labeling requirements. Confirmed sensitizer; IFRA restricts use by product category per QRA2 risk assessment framework. The EU classifies Hexyl Cinnamal as "restricted". Safety rating: MODERATE.

Is Hexyl Cinnamal allowed in the EU?

Hexyl Cinnamal EU regulatory status: restricted. Maximum allowed concentration: Mandatory labeling in leave-on products at >0.001%; rinse-off >0.01%. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexyl Cinnamal do in cosmetics?

Hexyl Cinnamal functions as: Skin Conditioning. It is classified as a Fragrance in our database. CAS number: 101-86-0.

What is the Margin of Safety for Hexyl Cinnamal?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Hexyl Cinnamal compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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