NOAEL Data REACH Registered Cosmetic Ingredient

1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol)

Also known as: 1,1',1'',1'''-(Ethane-1,2-diyldinitrilo)tetrapropan-2-ol, Edetol, 2-Propanol, 1,1′,1′′,1′′′-(1,2-ethanediyldinitrilo)tetrakis-, N,N,N',N'-Tetrakis(2-Hydroxypropyl)ethylenediamine, N,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine (+12 more)

CAS 102-60-3

1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol) (CAS 102-60-3) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Tetrahydroxypropyl Ethylenediamine →

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 23 fields

Name

1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol)

CAS Number

102-60-3

DTXSID

DTXSID9026689

Molecular Formula

C14H32N2O4

InChI Key

NSOXQYCFHDMMGV-UHFFFAOYSA-N

Monoisotopic Mass

292.236208

Synonyms

1,1',1'',1'''-(Ethane-1,2-diyldinitrilo)tetrapropan-2-olEdetol2-Propanol, 1,1′,1′′,1′′′-(1,2-ethanediyldinitrilo)tetrakis-N,N,N',N'-Tetrakis(2-Hydroxypropyl)ethylenediamineN,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-4-04-00-01685Adeka QuadrolBRN 1781143EINECS 203-041-4ENTPROL1,1',1'',1'''-(Ethylenedinitrilo)tetrakis(2-propanol)

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 12 records

Chelating agentFragrance

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
IFRA Transparency	IFRA	IFRA
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
pharmaceutical	US International Trade Commission	CPCat
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
Europe; Personal care	Danish Environmental Protection Agency	Danish EPA
active_ingredient; Europe; Pesticides	Commission of the European Communities	CPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 15 of 15 studies

Value	Unit	Endpoint	Route	Species	Source
-	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
=29.4	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
Q4R969U9FR	UNII	FDA UNII substance identifier	-	-	openFDA substances
Q4R969U9FR	UNII	FDA UNII substance identifier	-	-	openFDA substances
Q4R969U9FR	UNII	FDA UNII substance identifier	-	-	openFDA substances
Q4R969U9FR	UNII	FDA UNII substance identifier	-	-	openFDA substances
=2170	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
-	unitless	Model Score	-	-	NTP_ICE_endocrine
=300	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=500	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
>=600	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HPVIS
<=900	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_HPVIS
=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=720	mg/kg bw/day	NOEL	oral	Rat	ToxValDB_ECHA_IUCLID

Showing 15 of 15 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	1,1',1'',1'''-ethylenedinitrilotetrapropan-2-ol	203-041-4	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL EDETOL

ChEMBL Phase

Adverse Events

Bioactivity

View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol)?

1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol) has 15 NOAEL studies in the database. The lowest reported value is 0 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include 1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol)?

1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol) appears on 6 regulatory/inventory lists including IFRA Transparency, inert_ingredient; non_food_use; Pesticides, pharmaceutical, and 3 more. Source: EPA CPDat.

Is 1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol) used in cosmetics?

Yes, 1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol) is also indexed as a cosmetic ingredient under the name Tetrahydroxypropyl Ethylenediamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol) come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol) used outside industrial chemicals?

1,1′,1′′,1′′′-(Ethylenedinitrilo)tetrakis(2-propanol) also appears in cosmetics, pharmaceutical databases.