Is Tetrahydroxypropyl Ethylenediamine safe in cosmetics?
Tetrahydroxypropyl Ethylenediamine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 4 toxicological study endpoint(s) are available in our database.
Tetrahydroxypropyl Ethylenediamine
Also known as: 1,1',1'',1'''-(Ethane-1,2-diyldinitrilo)tetrapropan-2-ol, Edetol, 2-Propanol, 1,1′,1′′,1′′′-(1,2-ethanediyldinitrilo)tetrakis-, N,N,N',N'-Tetrakis(2-Hydroxypropyl)ethylenediamine, N,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine (+12 more)
INCI: TETRAHYDROXYPROPYL ETHYLENEDIAMINE
Tetrahydroxypropyl Ethylenediamine (CAS 102-60-3) is a cosmetic cosmetic ingredient functioning as Chelating agent, buffering agent, pH adjuster. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Chelating agent, buffering agent, pH adjuster
Editorial assessment
GOOD
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
1-[2-[bis(2-hydroxypropyl)amino]ethyl-(2-hydroxypropyl)amino]propan-2-ol
InChIKey
NSOXQYCFHDMMGV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted; CIR reviewed as safe with qualifications
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydroxypropyl Ethylenediamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Tetrahydroxypropyl Ethylenediamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =500 mg/kg bw/day | oral | Rat | subchronic | ECHA |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | developmental | ECHA |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ECHA |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tetrahydroxypropyl Ethylenediamine across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Fragrance
Regulatory List Membership (3)
EU Regulated in Personal Care
IFRA Fragrance Transparency List
FDA Indirect Food Contact Additives
Editorial summary
Preliminary editorial summary for Tetrahydroxypropyl Ethylenediamine — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
potential-allergen
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tetrahydroxypropyl Ethylenediamine by CAS number or substance name.
Studies
4
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ECHA
Known Synonyms
1,1',1'',1'''-(Ethane-1,2-diyldinitrilo)tetrapropan-2-ol
Edetol
2-Propanol, 1,1′,1′′,1′′′-(1,2-ethanediyldinitrilo)tetrakis-
N,N,N',N'-Tetrakis(2-Hydroxypropyl)ethylenediamine
N,N,N′,N′-Tetrakis(2-hydroxypropyl)ethylenediamine
2-Propanol, 1,1',1'',1'''-(1,2-ethanediyldinitrilo)tetrakis-
4-04-00-01685
Adeka Quadrol
BRN 1781143
EINECS 203-041-4
ENTPROL
1,1',1'',1'''-(Ethylenedinitrilo)tetrakis(2-propanol)
NSC 369219
Quadrol
Quadrol L
Edetolum
UNII-Q4R969U9FR
Chemical Function
Chelating agent
Fragrance
Regulatory Lists
IFRA Transparency
inert_ingredient; non_food_use; Pesticides
pharmaceutical
Indirect additives food contact (10/2018)
Europe; Personal care
Europe; Personal care
active_ingredient; Europe; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EDETOL
ChEMBL ID
CHEMBL1573178
Max Phase
2
Frequently Asked Questions
Is Tetrahydroxypropyl Ethylenediamine allowed in the EU?
Tetrahydroxypropyl Ethylenediamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydroxypropyl Ethylenediamine do in cosmetics?
Tetrahydroxypropyl Ethylenediamine functions as: Chelating agent, buffering agent, pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 102-60-3.
What is the NOAEL for Tetrahydroxypropyl Ethylenediamine?
The NOAEL (No Observed Adverse Effect Level) for Tetrahydroxypropyl Ethylenediamine is =300 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 4 study endpoints are available. Source: ECHA.
Is Tetrahydroxypropyl Ethylenediamine used outside cosmetics?
Tetrahydroxypropyl Ethylenediamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Tetrahydroxypropyl Ethylenediamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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