Tetrahydroxypropyl Ethylenediamine
INCI: TETRAHYDROXYPROPYL ETHYLENEDIAMINE
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Tetrahydroxypropyl Ethylenediamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | oral | REACH |
| LOAEL | 2170 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 500 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Related to ethylenediamine family (known sensitizer in raw form); hydroxypropyl groups significantly reduce sensitization risk
Regulatory Flags
Frequently Asked Questions
Is Tetrahydroxypropyl Ethylenediamine safe in cosmetics?
Related to ethylenediamine family (known sensitizer in raw form); hydroxypropyl groups significantly reduce sensitization risk The EU classifies Tetrahydroxypropyl Ethylenediamine as "permitted". Safety rating: GOOD. 3 toxicological study endpoint(s) are available in our database.
Is Tetrahydroxypropyl Ethylenediamine allowed in the EU?
Tetrahydroxypropyl Ethylenediamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydroxypropyl Ethylenediamine do in cosmetics?
Tetrahydroxypropyl Ethylenediamine functions as: Chelating agent, buffering agent, pH adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 102-60-3.
What is the Margin of Safety for Tetrahydroxypropyl Ethylenediamine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Tetrahydroxypropyl Ethylenediamine?
The NOAEL (No Observed Adverse Effect Level) for Tetrahydroxypropyl Ethylenediamine is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 3 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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