Danger GHS06GHS08GHS05GHS09 NOAEL Data Cosmetic Ingredient

2,2-Dibromo-3-nitrilopropionamide

Also known as: DBNPA, Acetamide, 2,2-dibromo-2-cyano-, Acetamide, 2-cyano-2,2-dibromo-, 3-02-00-01641, BRN 1761192 (+8 more)

CAS 10222-01-2

2,2-Dibromo-3-nitrilopropionamide (CAS 10222-01-2) is a chemical substance with GHS signal word Danger; key hazard signal: H330; H301; H372 (inhalation) (respiratory tract); H315; H318; H317; H400; H410. Key regulatory status: 22 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS.

View cosmetic safety profile for Dibromocyanoacetamide (DBNPA) →

SOURCE noael studies public
NOAEL studies
34
SOURCE chemical inventory jurisdictions
Regulatory lists
22
SOURCE eu clp annex vi
GHS signal
Danger

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 19 fields
Name
2,2-Dibromo-3-nitrilopropionamide
CAS Number
10222-01-2
DTXSID
DTXSID5032361
Molecular Formula
C3H2Br2N2O
InChI Key
UUIVKBHZENILKB-UHFFFAOYSA-N
Monoisotopic Mass
239.853388
Synonyms
DBNPAAcetamide, 2,2-dibromo-2-cyano-Acetamide, 2-cyano-2,2-dibromo-3-02-00-01641BRN 1761192Caswell No. 287AA2,2-Dibromo-2-carbamoylacetonitrileDibromocyanoacetamideEINECS 233-539-7EPA Pesticide Chemical Code 101801NSC 98283XD-7287l Antimicrobial

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
Acute Tox. 2; Acute Tox. 3; STOT RE 1; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1H330; H301; H372 (inhalation) (respiratory tract); H315; H318; H317; H400; H410GHS06; GHS08; GHS05; GHS09Danger

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 7 records
Biocide

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 22 records
ListKeywordSource
CEDIFDAUnited States Food and Drug Administration (FDA)
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)FDAUnited States Food and Drug Administration (FDA)
active_ingredient; Europe; PesticidesCommission of the European CommunitiesCPCat
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesState of CaliforniaState of California
active_ingredient; PesticidesCalifornia Department of Pesticide RegulationState of California
fracking; waterNY Department of ConservationCPCat

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 34 of 34 studies
ValueUnitEndpointRouteSpeciesSource
7N51QGL6MJUNIIFDA UNII substance identifier--openFDA substances
7N51QGL6MJUNIIFDA UNII substance identifier--openFDA substances
7N51QGL6MJUNIIFDA UNII substance identifier--openFDA substances
7N51QGL6MJUNIIFDA UNII substance identifier--openFDA substances
=9.546mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=9.546mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=10.7mg/kg bw/dayLELoralDogToxValDB_ToxRefDB
=10.7mg/kg bw/dayLELoraldog (beagle; beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=11.6mg/kg bw/dayLELoralDogToxValDB_ToxRefDB
=11.6mg/kg bw/dayLELoraldog (beagle; beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=30mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=30mg/kg bw/dayLELoralrat (sprague dawley; Sprague Dawley (CD))ToxRefDB_ToxRefDB_v3_pod.csv
=50mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=50mg/kg bw/dayLELoralrat (sprague dawley; Sprague Dawley (CD))ToxRefDB_ToxRefDB_v3_pod.csv
=71.32mg/kg bw/dayLELoralRatToxValDB_ToxRefDB
=71.32mg/kg bw/dayLELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=71.29mg/kg bw/dayLOAELoralRatToxValDB_ToxRefDB
=71.29mg/kg bw/dayLOAELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
-unitlessModel Score--NTP_ICE_endocrine
=1.431mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=1.431mg/kg bw/dayNELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=5mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=5mg/kg bw/dayNELoralrat (sprague dawley; Sprague Dawley (CD))ToxRefDB_ToxRefDB_v3_pod.csv
=5.9mg/kg bw/dayNELoralDogToxValDB_ToxRefDB
=5.9mg/kg bw/dayNELoraldog (beagle; beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=6.1mg/kg bw/dayNELoralDogToxValDB_ToxRefDB
=6.1mg/kg bw/dayNELoraldog (beagle; beagle)ToxRefDB_ToxRefDB_v3_pod.csv
=9.551mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=9.551mg/kg bw/dayNELoralrat (fischer; Fischer 344)ToxRefDB_ToxRefDB_v3_pod.csv
=15mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=15mg/kg bw/dayNELoralrat (sprague dawley; Sprague Dawley (CD))ToxRefDB_ToxRefDB_v3_pod.csv
=25mg/kg bw/dayNELoralRatToxValDB_ToxRefDB
=25mg/kg bw/dayNELoralrat (sprague dawley; Sprague Dawley (CD))ToxRefDB_ToxRefDB_v3_pod.csv
58.5mg/kg bw/dayNOAELoralratCOSMOS_DB

Showing 34 of 34 studies

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Preservative
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1878278
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Frequently Asked Questions

What is the GHS hazard classification for 2,2-Dibromo-3-nitrilopropionamide?

2,2-Dibromo-3-nitrilopropionamide (CAS 10222-01-2) is classified under EU CLP Annex VI as Acute Tox. 2; Acute Tox. 3; STOT RE 1; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1 with signal word Danger. Hazard statements: H330; H301; H372 (inhalation) (respiratory tract); H315; H318; H317; H400; H410. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2,2-Dibromo-3-nitrilopropionamide?

2,2-Dibromo-3-nitrilopropionamide has 34 NOAEL studies in the database. The lowest reported value is 7N51QGL6MJ UNII. Source: openFDA substances.

What regulatory lists include 2,2-Dibromo-3-nitrilopropionamide?

2,2-Dibromo-3-nitrilopropionamide appears on 5 regulatory/inventory lists including CEDI, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), active_ingredient; Europe; Pesticides, and 2 more. Source: EPA CPDat.

Is 2,2-Dibromo-3-nitrilopropionamide used in cosmetics?

Yes, 2,2-Dibromo-3-nitrilopropionamide is also indexed as a cosmetic ingredient under the name Dibromocyanoacetamide (DBNPA). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2-Dibromo-3-nitrilopropionamide come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Does 2,2-Dibromo-3-nitrilopropionamide have different safety status in cosmetics vs industrial chemicals?

2,2-Dibromo-3-nitrilopropionamide is classified GHS Danger (H330, H301, H372, H315, H318, H317, H400, H410) in the chemicals database but is allowed in EU cosmetics.

Is 2,2-Dibromo-3-nitrilopropionamide used outside industrial chemicals?

2,2-Dibromo-3-nitrilopropionamide also appears in cosmetics, pharmaceutical databases.