Is Dibromocyanoacetamide (DBNPA) safe in cosmetics?
Dibromocyanoacetamide (DBNPA) has a safety rating of "POOR" in our database. EU status: permitted. US status: prohibited.
Poor
Cosmetic Ingredient
Dibromocyanoacetamide (DBNPA)
Also known as: DBNPA, Acetamide, 2,2-dibromo-2-cyano-, Acetamide, 2-cyano-2,2-dibromo-, 3-02-00-01641, BRN 1761192 (+7 more)
INCI: DIBROMOCYANOACETAMIDE
Dibromocyanoacetamide (DBNPA) (CAS 10222-01-2) is a cosmetic cosmetic ingredient functioning as Antimicrobial / biocide (industrial preservative). NOAEL 5 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 10222-01-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Dibromocyanoacetamide (DBNPA) is classified GHS Danger (H301, H318, H331, H410, H315, H317, H330, H372) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antimicrobial / biocide (industrial preservative)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2,2-dibromo-2-cyanoacetamide
InChIKey
UUIVKBHZENILKB-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Registered as EPA biocide; not specifically prohibited by FDA for cosmetics, but primary registration is industrial — cosmetic use would require full safety substantiation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Dibromocyanoacetamide (DBNPA).
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Dibromocyanoacetamide (DBNPA) across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Acute ToxicityHealth HazardCorrosiveEnvironmental Hazard
Hazard Class and Category
Acute Tox. 2; Acute Tox. 3; STOT RE 1; Skin Irrit. 2; Eye Dam. 1; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H330 Fatal if inhaled
- H301 Toxic if swallowed
- H372 (inhalation) (respiratory tract)
- H315 Causes skin irritation
- H318 Causes serious eye damage
- H317 May cause an allergic skin reaction
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
inhalation: ATE = 0.24 mg/L dusts or mists; oral: ATE = 118.0 mg/kg bw; M = 1; M = 1
Inserted via ATP: ATP17
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Confirmed
Evidence: High
(2021)
Health effects: Yes
Affected pathways: Thyroid/Steroidogenesis
Regulatory framework: BPR
Source list: I
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Skin Eye Respiratory Irritation
A severe skin & eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Dibromocyanoacetamide (DBNPA).
Regulatory Flags
potential-allergen
preservative
fda_food_additive
Known Synonyms
DBNPA
Acetamide, 2,2-dibromo-2-cyano-
Acetamide, 2-cyano-2,2-dibromo-
3-02-00-01641
BRN 1761192
Caswell No. 287AA
2,2-Dibromo-2-carbamoylacetonitrile
EINECS 233-539-7
EPA Pesticide Chemical Code 101801
NSC 98283
XD-7287l Antimicrobial
UNII-7N51QGL6MJ
Chemical Function
Biocide
Regulatory Lists
CEDI
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
active_ingredient; Europe; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1878278
Frequently Asked Questions
Is Dibromocyanoacetamide (DBNPA) allowed in the EU?
Dibromocyanoacetamide (DBNPA) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Dibromocyanoacetamide (DBNPA) do in cosmetics?
Dibromocyanoacetamide (DBNPA) functions as: Antimicrobial / biocide (industrial preservative). It is classified as a cosmetic ingredient in our database. CAS number: 10222-01-2.
Is Dibromocyanoacetamide (DBNPA) used outside cosmetics?
Dibromocyanoacetamide (DBNPA) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Dibromocyanoacetamide (DBNPA) have different safety status in cosmetics vs industrial chemicals?
Dibromocyanoacetamide (DBNPA) is classified GHS Danger (H301, H318, H331, H410, H315, H317, H330, H372) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Dibromocyanoacetamide (DBNPA) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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