Warning GHS07 NOAEL Data IARC Group 2B Prop 65 REACH Registered Cosmetic Ingredient

2-Ethylhexyl acrylate

Also known as: Acido 2-propenoico, 2-etil hexil ester, EC No.: 203-080-7, BRN 1765828, EINECS 203-080-7, 2-Ethyl-1-hexyl acrylate (+7 more)

CAS 103-11-7

2-Ethylhexyl acrylate (CAS 103-11-7) is a chemical substance with GHS signal word Warning; key hazard signal: H335; H315; H317. Key regulatory status: California Proposition 65, REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from ECHA CLP, EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, CA Prop 65, ILO ICSC.

View cosmetic safety profile for Ethylhexyl Acrylate (monomer) →

SOURCE noael studies public
NOAEL studies
43
SOURCE chemical inventory jurisdictions
Regulatory lists
10
SOURCE eu clp annex vi
GHS signal
Warning

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 18 fields
Name
2-Ethylhexyl acrylate
CAS Number
103-11-7
DTXSID
DTXSID9025297
Molecular Formula
C11H20O2
InChI Key
GOXQRTZXKQZDDN-UHFFFAOYSA-N
Monoisotopic Mass
184.14633
Synonyms
Acido 2-propenoico, 2-etil hexil esterEC No.: 203-080-7BRN 1765828EINECS 203-080-72-Ethyl-1-hexyl acrylate1-Hexanol, 2-ethyl-, acrylate2-Ethylhexylester kyseliny akryloveUNII-HR49R9S6XGNorsocryl 2-EHA2EHAEHA203-080-7

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records
GroupMeaningEvaluatedVolume
Group 2BPossibly carcinogenic201860, 122

California Proposition 65

California OEHHA listing status and toxicity category.

SOURCE California OEHHA Proposition 65 List 1 records
ChemicalToxicity TypeCancerDevelopmentalListed
-cancerYesNo-

GHS / CLP Classification

EU harmonized hazard classification, hazard statements, pictograms, and signal word.

SOURCE EU CLP Annex VI (ECHA) 1 classifications
Hazard ClassH-StatementsPictogramsSignal
STOT SE 3; Skin Irrit. 2; Skin Sens. 1H335; H315; H317GHS07Warning

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records
FieldValue
Short-term EffectsThe substance is irritating to the eyes, skin and respiratory tract.
Long-term EffectsRepeated or prolonged contact may cause skin sensitization.
Routes of ExposureThe substance can be absorbed into the body by inhalation and by ingestion.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 10 records
BinderAdhesion/cohesion promoterAnti-stain agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 10 records
ListKeywordSource
inert_ingredient; non_food_use; PesticidesEPACPCat
Indirect additives food contact (10/2018)FDAUnited States Food and Drug Administration (FDA)
OEHHA Proposition 65 (1/2023)California Office of Environmental Health Hazard AssessmentOEHHA Proposition 65 List
air; Cons electronics mech appliances and machinery; detected; emissions; Europe-Danish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; EuropeDanish Environmental Protection AgencyDanish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; EuropeDanish Environmental Protection AgencyDanish EPA
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; detected; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA
air; Cons electronics mech appliances and machinery; detected; emissions; EuropeDanish Environmental Protection AgencyDanish EPA

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 43 of 43 studies
ValueUnitEndpointRouteSpeciesSource
103.77ug/mLCD54, EC200Dermal-NTP_ICE_skin_sensitization
range6.249ug/mLCD86, EC120Dermal-NTP_ICE_skin_sensitization
99.96ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
>1289.953ug/mLCD86, EC150Dermal-NTP_ICE_skin_sensitization
280ug/mLCV75Dermal-NTP_ICE_skin_sensitization
LCcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
LCcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
LCcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
LCcancerlisting typeCalifornia Proposition 65 listing--California Proposition 65
=38mg/m3DNEL localinhalationHumanToxValDB_GESTIS_DNEL
6.3%Depletion CysDermal-NTP_ICE_skin_sensitization
98.8%Depletion CysDermal-NTP_ICE_skin_sensitization
100%Depletion CysDermal-NTP_ICE_skin_sensitization
20.9%Depletion LysDermal-NTP_ICE_skin_sensitization
21.5%Depletion LysDermal-NTP_ICE_skin_sensitization
34.1%Depletion LysDermal-NTP_ICE_skin_sensitization
13.9%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
66.45%Depletion Lys + CysDermal-NTP_ICE_skin_sensitization
range1.47uMEC1.5Dermal-NTP_ICE_skin_sensitization
35.02uMEC1.5Dermal-NTP_ICE_skin_sensitization
9.7%EC3DermalMouseNTP_ICE_skin_sensitization
9.7%EC3DermalMouseNTP_ICE_skin_sensitization
9.7%EC3DermalMouseNTP_ICE_skin_sensitization
9.7%EC3DermalMouseNTP_ICE_skin_sensitization
36.8%EC3DermalMouseNTP_ICE_skin_sensitization
HR49R9S6XGUNIIFDA UNII substance identifier--openFDA substances
HR49R9S6XGUNIIFDA UNII substance identifier--openFDA substances
HR49R9S6XGUNIIFDA UNII substance identifier--openFDA substances
HR49R9S6XGUNIIFDA UNII substance identifier--openFDA substances
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2BIARC groupIARC carcinogenicity classification--IARC Monographs
2unitlessIARC group--NTP_ICE_cancer
101uMIC50Dermal-NTP_ICE_skin_sensitization
3.5ratioImaxDermal-NTP_ICE_skin_sensitization
=4435mg/kg bwLD50oralRatNTP_ICE_acute_oral
=5600mg/kg bwLD50oralRatNTP_ICE_acute_oral
=5720mg/kg bwLD50oralRat (Male)NTP_ICE_acute_oral
=6700mg/kg bwLD50oralRatNTP_ICE_acute_oral
=52759.1mg/m3LELinhalationHumanToxValDB_DOE_Protective_Action_Criteria
-unitlessModel Score--NTP_ICE_endocrine
~560mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID
~750mg/m3NOAECinhalationRatToxValDB_ECHA_IUCLID

Showing 43 of 43 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2-ethylhexyl acrylate203-080-7ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1574328
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the GHS hazard classification for 2-Ethylhexyl acrylate?

2-Ethylhexyl acrylate (CAS 103-11-7) is classified under EU CLP Annex VI as STOT SE 3; Skin Irrit. 2; Skin Sens. 1 with signal word Warning. Hazard statements: H335; H315; H317. Source: EU CLP Annex VI (ECHA).

What is the NOAEL for 2-Ethylhexyl acrylate?

2-Ethylhexyl acrylate has 43 NOAEL studies in the database. The lowest reported value is 0 unitless. Source: NTP_ICE_endocrine.

What regulatory lists include 2-Ethylhexyl acrylate?

2-Ethylhexyl acrylate appears on 6 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, Indirect additives food contact (10/2018), OEHHA Proposition 65 (1/2023), and 3 more. Source: EPA CPDat.

Is 2-Ethylhexyl acrylate a carcinogen according to IARC?

2-Ethylhexyl acrylate is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2018). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is 2-Ethylhexyl acrylate on the California Proposition 65 list?

Yes, 2-Ethylhexyl acrylate is listed under California Proposition 65 for cancer. Source: California OEHHA Proposition 65.

Is 2-Ethylhexyl acrylate used in cosmetics?

Yes, 2-Ethylhexyl acrylate is also indexed as a cosmetic ingredient under the name Ethylhexyl Acrylate (monomer). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2-Ethylhexyl acrylate come from?

Safety data is sourced from ECHA CLP Annex VI, EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, California Proposition 65, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 2-Ethylhexyl acrylate have different safety status in cosmetics vs industrial chemicals?

2-Ethylhexyl acrylate is prohibited in EU cosmetics but has active industrial GHS classifications (H335, H315, H317).

Is 2-Ethylhexyl acrylate used outside industrial chemicals?

2-Ethylhexyl acrylate also appears in cosmetics, pharmaceutical, cannabis databases.