Poor Cosmetic Ingredient NOAEL Data GHS Classified

Ethylhexyl Acrylate (monomer)

INCI: ETHYLHEXYL ACRYLATE

CAS Number
103-11-7
Function
Monomer — not intended for direct use in finished cosmetics; used in production of acrylate copolymers
Safety Rating
POOR

Regulatory Status

🇪🇺 EU Status prohibited
🇺🇸 US Status permitted
US Notes Permitted as polymerized form; no specific CFR ban but monomer use would fail safety assessment

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

5 study endpoints found for Ethylhexyl Acrylate (monomer). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 4.5 2080 dermal code:3543 dermal REACH
NOEL 7500 ppm oral rat oral REACH
NOEL 250 mg/kg bw/day oral rat oral REACH
NOAEL 50 ppm 1995 rat inhalation REACH
NOAEL 5000 ppm oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.

Expert Verdict

Strong skin sensitizer and skin irritant with respiratory irritant properties. The EU Risk Assessment Report identifies sensitization concern for all dermal exposure scenarios. In cosmetics, this ingredient exists only as residual monomer within polymerized copolymers; residual monomer specifications (typical <100 ppm, preferred <10 ppm) must be documented and tested.

⚠️
Concern Level: High

Regulatory Flags

potential-allergen prop65

Frequently Asked Questions

Is Ethylhexyl Acrylate (monomer) safe in cosmetics?

Strong skin sensitizer and skin irritant with respiratory irritant properties. The EU Risk Assessment Report identifies sensitization concern for all dermal exposure scenarios. In cosmetics, this ingredient exists only as residual monomer within polymerized copolymers; residual monomer specifications (typical <100 ppm, preferred <10 ppm) must be documented and tested. The EU classifies Ethylhexyl Acrylate (monomer) as "prohibited". Safety rating: POOR. 5 toxicological study endpoint(s) are available in our database.

Is Ethylhexyl Acrylate (monomer) allowed in the EU?

Ethylhexyl Acrylate (monomer) EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Ethylhexyl Acrylate (monomer) do in cosmetics?

Ethylhexyl Acrylate (monomer) functions as: Monomer — not intended for direct use in finished cosmetics; used in production of acrylate copolymers. It is classified as a cosmetic ingredient in our database. CAS number: 103-11-7.

What is the Margin of Safety for Ethylhexyl Acrylate (monomer)?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Ethylhexyl Acrylate (monomer)?

The NOAEL (No Observed Adverse Effect Level) for Ethylhexyl Acrylate (monomer) is 4.5 2080 based on a dermal study via dermal route in code:3543. A total of 5 study endpoints are available. Source: REACH.

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