NOAEL Data IARC Group 3 REACH Registered Cosmetic Ingredient

Bis(2-ethylhexyl)hexanedioate

Also known as: Adimoll DO, DEHA, Hexanedioic acid, bis(2-ethylhexyl) ester, Adipic acid, bis(2-ethylhexyl) ester, BRN 1803774 (+15 more)

CAS 103-23-1

Bis(2-ethylhexyl)hexanedioate (CAS 103-23-1) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC, ECHA REACH, ILO ICSC.

View cosmetic safety profile for Diethylhexyl Adipate →

Cross-Vertical Regulatory Divergence

Bis(2-ethylhexyl)hexanedioate is classified GHS CMR hazard (H336, H361) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 26 fields

Name

Bis(2-ethylhexyl)hexanedioate

CAS Number

103-23-1

DTXSID

DTXSID0020606

Molecular Formula

C22H42O4

InChI Key

SAOKZLXYCUGLFA-UHFFFAOYSA-N

Monoisotopic Mass

370.30831

Synonyms

Adimoll DODEHAHexanedioic acid, bis(2-ethylhexyl) esterAdipic acid, bis(2-ethylhexyl) esterBRN 1803774Di(2-ethylhexyl)adipateEINECS 203-090-1Flexol plasticizer A-26Flexol plasticizer 10-AHexanedioic acid, dioctyl esterKemester 5652Mollan S

IARC Carcinogen Classification

Carcinogenic hazard classification from IARC monograph evaluations.

SOURCE IARC Monographs on the Identification of Carcinogenic Hazards to Humans 1 records

Group	Meaning	Evaluated	Volume
Group 3	Not classifiable	2000	Sup 7, 77

ICSC Chemical Safety

International Chemical Safety Card hazard and exposure summary.

SOURCE ILO/WHO International Chemical Safety Cards 1 records

Field	Value
GHS Signal Word	WARNING
GHS Hazard Statements	Causes eye irritation May be harmful if swallowed and enters airways Very toxic to aquatic life
Short-term Effects	The substance is mildly irritating to the eyes. If swallowed the substance easily enters the airways and could result in aspiration pneumonitis.

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 54 records

SolventSoftener and conditionerFilm formerPlasticizerDegradant/impurityNo specific technical functionPigmentFragranceLubricating agentDispersing agent

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
Europe; plastic_additive	European Chemicals Agency	European Chemicals Agency (ECHA)
Arts and crafts/Office supplies - home office - pens and markers; detected; Europe	Danish Environmental Protection Agency	Danish EPA
Indirect additives food contact (10/2018)	FDA	United States Food and Drug Administration (FDA)
IFRA Transparency	IFRA	IFRA
consumer_product	P&G	Proctor & Gamble
inert_ingredient; non_food_use; Pesticides	EPA	CPCat
detected; Toys and children's products	Journal of Exposure Science & Environmental Epidemiology	Published Articles

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 62 studies

Value	Unit	Endpoint	Route	Species	Source
13.56	uL/min/10^6 cells	Clint	-	Human	NTP_ICE_adme_parameters
MBY1SL921L	UNII	FDA UNII substance identifier	-	-	openFDA substances
MBY1SL921L	UNII	FDA UNII substance identifier	-	-	openFDA substances
MBY1SL921L	UNII	FDA UNII substance identifier	-	-	openFDA substances
MBY1SL921L	UNII	FDA UNII substance identifier	-	-	openFDA substances
0.03861	fraction	Fu	-	Human	NTP_ICE_adme_parameters
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	IARC group	IARC carcinogenicity classification	-	-	IARC Monographs
3	unitless	IARC group	-	-	NTP_ICE_cancer
=5600	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=9100	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=9110	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=19100	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>20000	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
=25000	mg/kg bw	LD50	oral	Rat (Female)	NTP_ICE_acute_oral
=45000	mg/kg bw	LD50	oral	Rat (Male)	NTP_ICE_acute_oral
=625	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=625	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=945	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=945	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=1250	mg/kg bw/day	LEL	oral	Rat	ToxValDB_ToxRefDB
=1250	mg/kg bw/day	LEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=1800	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=1800	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=3750	mg/kg bw/day	LEL	oral	Mouse	ToxValDB_ToxRefDB
=3750	mg/kg bw/day	LEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=60625.9	mg/m3	LEL	inhalation	Human	ToxValDB_DOE_Protective_Action_Criteria
=1080	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_IRIS
=2220	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ECHA_IUCLID
=2500	mg/kg bw/day	LOAEL	oral	Rat	ToxValDB_ToxRefDB
=2500	mg/kg bw/day	LOAEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=7500	mg/kg bw/day	LOAEL	oral	Mouse	ToxValDB_ToxRefDB
=7500	mg/kg bw/day	LOAEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
-	unitless	Model Score	-	-	NTP_ICE_endocrine
>-	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=240	mg/kg bw/day	NEL	oral	Mouse	ToxValDB_ToxRefDB
=240	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=315	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=315	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=465	mg/kg bw/day	NEL	oral	Mouse	ToxValDB_ToxRefDB
=465	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
=600	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=600	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=625	mg/kg bw/day	NEL	oral	Rat	ToxValDB_ToxRefDB
=625	mg/kg bw/day	NEL	oral	rat (fischer; Fischer 344)	ToxRefDB_ToxRefDB_v3_pod.csv
=1875	mg/kg bw/day	NEL	oral	Mouse	ToxValDB_ToxRefDB
=1875	mg/kg bw/day	NEL	oral	mouse (b6c3f1; B6C3F1)	ToxRefDB_ToxRefDB_v3_pod.csv
~170	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=170	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_IRIS

Showing 50 of 62 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Bis(2-ethylhexyl) adipate	203-090-1	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL CHEMBL1414950

ChEMBL Phase

Not listed

Adverse Events

Bioactivity

View full pharmaceutical profile →

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for Bis(2-ethylhexyl)hexanedioate?

Bis(2-ethylhexyl)hexanedioate has 62 NOAEL studies in the database. The lowest reported value is 13.56 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.

What regulatory lists include Bis(2-ethylhexyl)hexanedioate?

Bis(2-ethylhexyl)hexanedioate appears on 7 regulatory/inventory lists including Europe; plastic_additive, Arts and crafts/Office supplies - home office - pens and markers; detected; Europe, Indirect additives food contact (10/2018), and 4 more. Source: EPA CPDat.

Is Bis(2-ethylhexyl)hexanedioate a carcinogen according to IARC?

Bis(2-ethylhexyl)hexanedioate is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 2000). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.

Is Bis(2-ethylhexyl)hexanedioate used in cosmetics?

Yes, Bis(2-ethylhexyl)hexanedioate is also indexed as a cosmetic ingredient under the name Diethylhexyl Adipate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for Bis(2-ethylhexyl)hexanedioate come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does Bis(2-ethylhexyl)hexanedioate have different safety status in cosmetics vs industrial chemicals?

Bis(2-ethylhexyl)hexanedioate is classified GHS CMR hazard (H336, H361) in the chemicals database but is allowed in EU cosmetics.

Is Bis(2-ethylhexyl)hexanedioate used outside industrial chemicals?

Bis(2-ethylhexyl)hexanedioate also appears in cosmetics, pharmaceutical, cannabis databases.