Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
9 study endpoints found for Diethylhexyl Adipate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 200 mg/kg bw/day | intravenous | rat | other | REACH |
| NOAEL | 12000 ppm | oral | rat | oral | REACH |
| NOAEL | 200 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 6300 ppm | oral | rat | oral | REACH |
| NOAEL | 1600 ppm | oral | mouse | oral | REACH |
| NOAEL | 12500 ppm | oral | rat | oral | REACH |
| NOAEL | 12500 ppm | oral | mouse | oral | REACH |
| NOAEL | 0.15 other | oral | mouse | oral | REACH |
| NOAEL | ca.0.15 other | oral | rat | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Safe for cosmetic use per CIR with clean regulatory status, though dermal absorption data gap exists.
Regulatory Flags
Frequently Asked Questions
Is Diethylhexyl Adipate safe in cosmetics?
Safe for cosmetic use per CIR with clean regulatory status, though dermal absorption data gap exists. The EU classifies Diethylhexyl Adipate as "permitted". Safety rating: GOOD. 9 toxicological study endpoint(s) are available in our database.
Is Diethylhexyl Adipate allowed in the EU?
Diethylhexyl Adipate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diethylhexyl Adipate do in cosmetics?
Diethylhexyl Adipate functions as: Emollient, plasticizer, skin conditioning agent, film former, solvent for UV filters. It is classified as a cosmetic ingredient in our database. CAS number: 103-23-1.
What is the Margin of Safety for Diethylhexyl Adipate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diethylhexyl Adipate?
The NOAEL (No Observed Adverse Effect Level) for Diethylhexyl Adipate is 200 mg/kg bw/day based on a other study via intravenous route in rat. A total of 9 study endpoints are available. Source: REACH.
Is Diethylhexyl Adipate classified as hazardous under GHS?
Diethylhexyl Adipate carries a GHS signal word of "WARNING". Hazard statements: Causes eye irritation May be harmful if swallowed and enters airways Very toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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Related Ingredients
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