What is the NOAEL for 2-Phenylethyl acetate?
2-Phenylethyl acetate has 13 NOAEL studies in the database. The lowest reported value is 6.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Phenylethyl acetate
Also known as: Acetic acid, 2-phenylethyl ester, BRN 0638179, EINECS 203-113-5, Ethanol, 2-phenyl-, acetate, FEMA No. 2857 (+4 more)
CAS 103-45-7
2-Phenylethyl acetate (CAS 103-45-7) is a chemical substance. Key regulatory status: REACH registered, 10 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
2-Phenylethyl acetate is classified GHS Danger (H318, H319) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
13
SOURCE
chemical inventory jurisdictions
Regulatory lists
10
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
2-Phenylethyl acetate
CAS Number
103-45-7
DTXSID
DTXSID7044506
Molecular Formula
C10H12O2
InChI Key
MDHYEMXUFSJLGV-UHFFFAOYSA-N
Monoisotopic Mass
164.08373
Synonyms
Acetic acid, 2-phenylethyl esterBRN 0638179EINECS 203-113-5Ethanol, 2-phenyl-, acetateFEMA No. 2857UNII-67733846OWacetic acid beta-phenylethyl esterbeta-phenethyl acetatebeta-phenylethyl acetate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
18 records
DeodorizerNo specific technical functionFlavouring and nutrientFragrance
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
10 records
| List | Keyword | Source |
|---|---|---|
| air; detected; emissions; Europe; Vehicle - car interior - auto air freshener | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 13 of 13 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =6.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 67733846OW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 67733846OW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 67733846OW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 67733846OW | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1550 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| 6480 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >0.5 | mg/L | LC50 | Inhalation | - | NTP_ICE_acute_inhalation |
| =3670 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =5200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 13 of 13 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Phenethyl acetate | 203-113-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Other
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184025
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Phenylethyl acetate?
2-Phenylethyl acetate appears on 9 regulatory/inventory lists including air; detected; emissions; Europe; Vehicle - car interior - auto air freshener, detected; Europe; Personal care - sexual wellness, detected; Europe; Vehicle - car interior, and 6 more. Source: EPA CPDat.
Is 2-Phenylethyl acetate used in cosmetics?
Yes, 2-Phenylethyl acetate is also indexed as a cosmetic ingredient under the name Phenethyl Acetate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Phenylethyl acetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Phenylethyl acetate have different safety status in cosmetics vs industrial chemicals?
2-Phenylethyl acetate is classified GHS Danger (H318, H319) in the chemicals database but is allowed in EU cosmetics.
Is 2-Phenylethyl acetate used outside industrial chemicals?
2-Phenylethyl acetate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.