Excellent Cosmetic Ingredient NOAEL Data

Phenethyl Acetate

INCI: PHENETHYL ACETATE

CAS Number
103-45-7
Function
Fragrance, Masking
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes FEMA GRAS #2857; no FDA cosmetic restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Phenethyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL ca.1000 mg/kg bw/day oral mouse oral REACH
NOAEL ca.1000 mg/kg bw/day oral mouse oral REACH
NOAEL ca.1000 mg/kg bw/day oral mouse oral REACH
NOAEL ca.1000 mg/kg bw/day oral mouse oral REACH
NOAEL 480 mg/kg bw/day oral rat oral REACH
NOAEL 480 mg/kg bw/day oral rat oral REACH
NOAEL 500 mg/kg bw/day oral rat oral REACH
NOAEL 500 mg/kg bw/day oral rat oral REACH
NOAEL ca.500 mg/kg bw/day oral rat oral REACH
NOAEL ca.500 mg/kg bw/day oral rat oral REACH

Expert Verdict

Phenethyl Acetate is a low-risk fragrance ester with decades of safe use, no EU restrictions, RIFM safety dossier support, and margin of safety greater than 2,600.

⚠️
Concern Level: None

Regulatory Flags

ifra_fragrance fda_food_additive jecfa_safe

Frequently Asked Questions

Is Phenethyl Acetate safe in cosmetics?

Phenethyl Acetate is a low-risk fragrance ester with decades of safe use, no EU restrictions, RIFM safety dossier support, and margin of safety greater than 2,600. The EU classifies Phenethyl Acetate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.

Is Phenethyl Acetate allowed in the EU?

Phenethyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Phenethyl Acetate do in cosmetics?

Phenethyl Acetate functions as: Fragrance, Masking. It is classified as a Cosmetic Ingredient in our database. CAS number: 103-45-7.

What is the Margin of Safety for Phenethyl Acetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Phenethyl Acetate?

The NOAEL (No Observed Adverse Effect Level) for Phenethyl Acetate is ca.1000 mg/kg bw/day based on a oral study via oral route in mouse. A total of 10 study endpoints are available. Source: REACH.

Compliance Tools

Check Phenethyl Acetate compliance across multiple jurisdictions:

🔬
Ingredient Decoder
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 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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