What is the NOAEL for 2-Phenylethyl 2-methylpropanoate?
2-Phenylethyl 2-methylpropanoate has 10 NOAEL studies in the database. The lowest reported value is 3.53 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Phenylethyl 2-methylpropanoate
Also known as: Propanoic acid, 2-methyl-, 2-phenylethyl ester, Phenethyl isobutyrate, Benzylcarbinol isobutyrate, Benzylcarbinyl isobutyrate, BRN 2330243 (+7 more)
CAS 103-48-0
2-Phenylethyl 2-methylpropanoate (CAS 103-48-0) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
2-Phenylethyl 2-methylpropanoate
CAS Number
103-48-0
DTXSID
DTXSID7044764
Molecular Formula
C12H16O2
InChI Key
JDQVBGQWADMTAM-UHFFFAOYSA-N
Monoisotopic Mass
192.11503
Synonyms
Propanoic acid, 2-methyl-, 2-phenylethyl esterPhenethyl isobutyrateBenzylcarbinol isobutyrateBenzylcarbinyl isobutyrateBRN 2330243EINECS 203-116-1FEMA No. 2862Phenethyl 2-methylpropionatePhenylethyl isobutyrate2-Phenylethyl 2-methylpropionateUNII-QRZ4RE7DCLbeta-phenylethyl isobutyrate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
49 records
FragranceNo specific technical functionFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =3.53 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| QRZ4RE7DCL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QRZ4RE7DCL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QRZ4RE7DCL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QRZ4RE7DCL | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 1296 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =5200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =1000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Phenethyl isobutyrate | 203-116-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL3184929
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Phenylethyl 2-methylpropanoate?
2-Phenylethyl 2-methylpropanoate appears on 5 regulatory/inventory lists including Australia; Food and drug - smoking-related products, IFRA Transparency, Europe, and 2 more. Source: EPA CPDat.
Is 2-Phenylethyl 2-methylpropanoate used in cosmetics?
Yes, 2-Phenylethyl 2-methylpropanoate is also indexed as a cosmetic ingredient under the name Phenethyl Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Phenylethyl 2-methylpropanoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Phenylethyl 2-methylpropanoate used outside industrial chemicals?
2-Phenylethyl 2-methylpropanoate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.